Abstract：
:The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followed by CD45RO(+), CD4(+), and CD8(+) T cells; CD57(+) natural killer cells; S-100(+) cells; and CD20(+) B lymphocytes. A 54-year-old man and living in the State of Para, Amazon region, Brazil, was seen with a lesion on the left lower limb, which had started as a small nodular area 18 years ago. The lesion showed progressive growth and disseminated to other parts of the body. Our findings showed that dermal immune response differs depending on the type of lesions and clinical presentation, with presence of CD1a(+), FXIIIa(+), CD45(+), CD4(+), CD8(+), and S-100(+) cells and cytokine profile with expression of interleukin 1 β, tumor necrosis factor α, transforming growth factor β, IL-10, and interferon γ.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Oliveira Carneiro FR,da Cunha Fischer TR,Brandão CM,Pagliari C,Duarte MI,Quaresma JAdoi
10.1016/j.humpath.2014.10.016subject
Has Abstractpub_date
2015-02-01 00:00:00pages
334-8issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00447-Xjournal_volume
46pub_type
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