Abstract：
:Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowded, enlarged, overlapping nuclei in three-dimensional groups or sheets, loss of cohesion, occasional single cells, a homogeneous cell population, chromatin changes, and increased cellularity in older patients. Our prospective series of 1,925 aspirations included 717 breast cases, of which 25 (3.5%) were considered sufficiently atypical to possibly represent proliferative lesions, but were not suspicious for carcinoma. Fifteen patients with histologic follow-up formed the basis for this study. All had physical examinations and mammogram results consistent with fibrocystic change. Their ages ranged from 30 to 70 years (median age, 44 years). Cytologic changes of atypia were cataloged. Histologically, six cases (40%) showed prognostically significant lesions (moderate, florid, or atypical hyperplasia and one lobular carcinoma in situ). Many (60%) cytologically provocative lesions may originate in prognostically trivial lesions. At this time our limited understanding of the cytologic presentation of these lesions indicates that surgical excision is essential in all instances. Efforts to recognize and properly classify these proliferations in cytologic material should continue.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Stanley MW,Henry-Stanley MJ,Zera Rdoi
10.1016/0046-8177(93)90243-asubject
Has Abstractpub_date
1993-06-01 00:00:00pages
630-5issue
6eissn
0046-8177issn
1532-8392pii
0046-8177(93)90243-Ajournal_volume
24pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.11.013
更新日期：2007-05-01 00:00:00
abstract：:Tissues obtained from 600 routine autopsies were studied. Mineral oil lipidosis was present in the spleen (76 per cent), liver (45 per cent), bone marrow (26 per cent), and lymph nodes; more than 50 per cent of the lymph nodes from the mesentery, porta hepatis, and mediastinum were affected. Mineral oil and its metabo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80163-x
更新日期：1984-08-01 00:00:00
abstract：:Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90292-w
更新日期：1991-07-01 00:00:00
abstract：:To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-r...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.04.008
更新日期：2018-08-01 00:00:00
abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80243-8
更新日期：1982-12-01 00:00:00
abstract：:To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PC...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(98)90046-6
更新日期：1998-03-01 00:00:00
abstract：:Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.08.011
更新日期：2019-01-01 00:00:00
abstract：:Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6, p63, GATA3, mammag...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.09.007
更新日期：2014-02-01 00:00:00
abstract：:The cell of origin of parafollicular (monocytoid) B cell lymphoma (PBCL), splenic marginal zone lymphoma (SMZL), and hairy cell leukemia (HCL) is controversial. To better understand the relationship between these low-grade B-cell neoplasms, we analyzed the nucleotide sequences of the rearranged immunoglobulin heavy (I...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90010-2
更新日期：1999-03-01 00:00:00
abstract：:The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90340-9
更新日期：1992-07-01 00:00:00
abstract：:Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating t...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2012.05.003
更新日期：2012-10-01 00:00:00
abstract：:A primary neoplasm of the proximal humerus in a 68-year-old woman was unique histologically in that it contained both malignant cartilaginous and squamous cell components. The epithelial differentiation was confirmed by the demonstration of keratin by immunohistochemical techniques and of basement membrane, tonofilame...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80227-5
更新日期：1986-03-01 00:00:00
abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.001
更新日期：2016-12-01 00:00:00
abstract：:Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.09.009
更新日期：2005-12-01 00:00:00
abstract：:Cancer cells show a higher rate of anaerobic respiration than normal cells. The exact mechanisms for this higher glycolysis rate in cancer cells remain to be elucidated. The results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulatio...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.04.021
更新日期：2012-02-01 00:00:00
abstract：:The national decline in hospital autopsy cases negatively impacts physician education and medical quality control to an unknown degree. The current non-medicolegal autopsy rate is less than 5% of hospital deaths. This study compares internal medicine and pathology resident physician perceptions of the autopsy, includi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.08.011
更新日期：2007-02-01 00:00:00
abstract：:Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.07.012
更新日期：2013-01-01 00:00:00
abstract：:Increasing differentiation in the human endometrium is associated with an apparent decrease in intercellular contacts between endometrial stromal cells ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90257-6
更新日期：1990-10-01 00:00:00
abstract：:We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.010
更新日期：2015-04-01 00:00:00
abstract：:Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic malignancy and is one of the best understood neoplasms, with relatively well-defined pathogenetic pathways, natural history, and tumor biology. Conventional clinical and pathologic parameters are widely used to grade and stage t...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2010.07.007
更新日期：2011-04-01 00:00:00
abstract：:Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.008
更新日期：2015-02-01 00:00:00
abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.023
更新日期：2015-12-01 00:00:00
abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.015
更新日期：2012-09-01 00:00:00
abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80164-6
更新日期：1983-10-01 00:00:00
abstract：:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.10.008
更新日期：2015-01-01 00:00:00
abstract：:As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:Endometrioid endometrial carcinomas (EECs) are correlated with high serum levels of androgens and estrogen. We hypothesized that Leydig cells and ovarian stromal hyperplasia contribute to postmenopausal ovarian androgen production and are observed more frequently in EEC patients. Ovaries of postmenopausal women with E...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.10.022
更新日期：2019-03-01 00:00:00
abstract：:Geotrichum candidum was identified as an invasive organism in the terminal ileum of a man with "hairy cell" leukemia. The organism was identified on the basis of histologic and cultural characteristics. The diagnostic features of G. candidum infection are compared to those of Aspergillus and Candida species. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80055-x
更新日期：1981-07-01 00:00:00
abstract：:The outcomes of patients with stage I non-small-cell lung cancer (NSCLC) vary greatly, with a 5-year survival rate of approximately 60%. This study evaluated a number of molecular markers that may aid in predicting prognosis in stage I NSCLC after surgical resection. Immunohistochemical (IHC) staining of p53, HER-2/ne...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.30183
更新日期：2002-01-01 00:00:00
abstract：:Human cytomegalovirus (HCMV) infection is usually reported in immunocompromised patients. This study reports 11 cases of HCMV infection of the gastrointestinal (GI) tract diagnosed in apparently immunocompetent hosts. The median age of the patients studied was 76 years, and the major presenting symptoms were diarrhea,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.08.005
更新日期：2003-12-01 00:00:00
