Abstract：
:Human cytomegalovirus (HCMV) infection is usually reported in immunocompromised patients. This study reports 11 cases of HCMV infection of the gastrointestinal (GI) tract diagnosed in apparently immunocompetent hosts. The median age of the patients studied was 76 years, and the major presenting symptoms were diarrhea, epigastric pain, and abdominal discomfort. The large intestine was involved in 6 cases, the stomach in 4 cases, and the lower esophagus in 1 case. Endoscopy revealed ulcers or hypertrophic folds in the GI tract and single ulcers or erosions in the colon and rectum. Light microscopy showed chronic inflammatory infiltrate in the lamina propria in all cases. The diagnosis of HCMV infection was based on the histological and immunohistochemical identification of HCMV inclusion bodies in different cell types, including epithelial, endothelial, stromal, and smooth muscle cells. Both "classical" inclusions, characterized by an "owl's eye" appearance, and atypical inclusions were found. For all patients, no apparent causes of immunodeficiency were detected at the time of diagnosis of HCMV infection. At follow-up, however, 4 patients were found to harbor a malignant tumor (ie, pancreas, lung, Vater's papilla, and extrahepatic bile duct) at an interval of 2 to 5 months after the diagnosis of HCMV infection. Especially in elderly patients, HCMV infection of the GI tract might be an early clue to the presence of immunologic defects induced by an underlying neoplasia.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Maiorana A,Baccarini P,Foroni M,Bellini N,Giusti Fdoi
10.1016/j.humpath.2003.08.005subject
Has Abstractpub_date
2003-12-01 00:00:00pages
1331-6issue
12eissn
0046-8177issn
1532-8392pii
S0046817703004775journal_volume
34pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.032
更新日期：2006-06-01 00:00:00
abstract：:We studied the histopathologic, immunohistochemical, and ultrastructural features of the extracellular matrix (ECM) in 20 immunologically defined large-cell lymphomas, including immunoblastic sarcoma of B cells (three patients), peripheral T cell lymphoma (five patients), large non-cleaved follicular center cell (FCC)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90181-0
更新日期：1989-02-01 00:00:00
abstract：:Hepatic artery thrombosis (HAT) following orthotopic liver transplantation (OLT) can cause hepatic parenchymal necrosis and ischemic cholangiopathy. This study investigates additional histologic features that may suggest HAT in post-OLT liver specimens. For 94 liver specimens (explanted allografts and biopsies) from p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.04.019
更新日期：2019-08-01 00:00:00
abstract：:Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90145-0
更新日期：1995-04-01 00:00:00
abstract：:Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.10.017
更新日期：2019-03-01 00:00:00
abstract：:Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal ant...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80235-1
更新日期：1988-12-01 00:00:00
abstract：:The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.017
更新日期：2010-11-01 00:00:00
abstract：:Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90094-4
更新日期：1989-09-01 00:00:00
abstract：:Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.01.013
更新日期：2016-06-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:There is considerable interest in the role of the human wart virus in the pathogenesis of squamous cell carcinoma. Mucosal wart virus infections may produce considerable epithelial atypia and have eventuated in carcinoma in "normal" individuals in some instances. The verruciform lesions of patients with epidermodyspla...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80108-6
更新日期：1981-02-01 00:00:00
abstract：:We applied a panel of antibodies to formalin-fixed, paraffin-embedded sections of 55 renal cell carcinomas using a three-stage immunoperoxidase technique. The antibody panel included two anti-keratins, AE1 and CAM5.2, anti-epithelial membrane antigen (EMA), anti-vimentin, anti-S100 protein, and the anti-leukocyte mark...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80016-9
更新日期：1988-08-01 00:00:00
abstract：:Immunofluorescence of formalin-fixed, paraffin-embedded tissues was performed to study the plasma cell population in 114 colonic specimens from 58 patients. Correlation of the histopathologic stage of disease activity with the isotypes and numbers of immunoglobulin-containing cells in the lamina propria demonstrated h...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80167-7
更新日期：1984-08-01 00:00:00
abstract：:A 3-year-old boy with congenital nemaline myopathy had generalized muscle weakness and hypotonia since birth. He developed cardiac symptoms at 2 years of age and died from congestive heart failure. At autopsy, the heart was markedly dilated, involving both ventricles. Rod bodies were recognized not only in skeletal mu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90078-j
更新日期：1990-01-01 00:00:00
abstract：:The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.01.010
更新日期：2011-11-01 00:00:00
abstract：:To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.10.012
更新日期：2006-02-01 00:00:00
abstract：:We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90406-2
更新日期：1996-07-01 00:00:00
abstract：:In a large-scale analysis of gene expression in pancreatic cancer, we isolated the homologue of the mouse Rab20. The mouse protein was previously identified during a search for novel Rab proteins, a family of small GTP-binding proteins involved in the regulation of intracellular vesicular transport. The Rab20 protein ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.10.017
更新日期：2006-03-01 00:00:00
abstract：:Pulmonary vein stenosis (PVS) is a rare disorder. Accurate diagnosis often requires anatomical examination. We report four children with pulmonary vein stenosis. Autopsy showed bilateral lesions in two patients who were thought clinically to have unilateral disease. A diagnosis of PVS was made at autopsy in the third ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90011-x
更新日期：1995-08-01 00:00:00
abstract：:We studied the histopathology and clinicopathologic correlates of invasive cavitary pulmonary aspergillosis in 11 immunosuppressed patients with disseminated malignancy. In most patients cavities were produced by separation of necrotic from viable lung, resulting in an intracavitary sequestrum ("lung ball"). Central d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90202-x
更新日期：1994-03-01 00:00:00
abstract：:Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.07.015
更新日期：2016-11-01 00:00:00
abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.03.028
更新日期：2012-12-01 00:00:00
abstract：:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：:Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90349-4
更新日期：1996-12-01 00:00:00
abstract：:In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80294-4
更新日期：1984-07-01 00:00:00
abstract：:Of the approximately 635 residents in each year of pathology training, about 165 are already meeting the Pathology Board's proposed requirement for a fifth year of resident training. The cost of a fifth year of training for the other 470 residents is estimated to be approximately $20 million. Options for avoiding this...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80159-8
更新日期：1984-08-01 00:00:00
abstract：:Malignant mesotheliomas are highly aggressive tumors that develop most frequently in the pleura of patients chronically exposed to asbestos. The distinction between malignant mesotheliomas and tumors of epithelial origin, particularly peripheral lung adenocarcinoma, can be difficult despite the use of immunocytochemic...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90302-x
更新日期：1995-12-01 00:00:00
abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.08.006
更新日期：2018-02-01 00:00:00
abstract：:A practical approach to the interpretation of peroral small intestinal biopsy specimens is presented. Biopsy technique and tissure handling are described. Interpretation of normal and abnormal biopsy specimens is discussed. A practical classification of abnormal small intestinal biopsies is presented and illustrated. ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(75)80176-6
更新日期：1975-03-01 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(89)90249-9
更新日期：1989-06-01 00:00:00
