Abstract:
:Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 chronic users of NSAIDs and 61 controls. Each specimen was graded from 0 to 3 for each of the following features: foveolar hyperplasia, smooth muscle fibers, edema, neutrophils, intestinal metaplasia, eosinophils, mononuclear cells, mucosal hemorrhage, atrophy, and Helicobacter pylori. We found that foveolar hyperplasia, considered one of the characteristic features of chemical gastropathy, was absent in 66% of NSAID users. Foveolar hyperplasia was present in 37 NSAID users (34%) and in 10 controls (18%); prominent smooth muscle fibers were found in 51 NSAID users (47%) and 10 of the controls (16%). Concurrent H pylori gastritis obscured the histopathologic changes of NSAID use. All other parameters, including H pylori infection rate (57% v 51%) were similar in NSAID users and controls. We conclude that the histological features characteristic of NSAID users were present only in a subset of patients. No single histological feature can be used to characterize or diagnose chemical gastropathy and no simple set of diagnostic criteria can be applied for this purpose.
journal_name
Hum Patholjournal_title
Human pathologyauthors
El-Zimaity HM,Genta RM,Graham DYdoi
10.1016/s0046-8177(96)90349-4subject
Has Abstractpub_date
1996-12-01 00:00:00pages
1348-54issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(96)90349-4journal_volume
27pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(99)90040-0
更新日期:1999-10-01 00:00:00
abstract::The drs gene was originally isolated from a rat primary embryo fibroblast cDNA library as a suppressor gene against v-src transformation. We have previously shown that expression of drs mRNA was markedly reduced in a variety of human cancer cell lines, including those of the colon, bladder, and ovary. Furthermore, int...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.125373
更新日期:2002-06-01 00:00:00
abstract::To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90088-x
更新日期:1993-04-01 00:00:00
abstract::Congenital subclavian steal may result from various anomalies of the aortic arch. The most common predisposing type is the right aortic arch with an isolated left subclavian artery arising from a left ductus arteriosus. A rare variant includes isolation of the left common carotid as well as the left subclavian arterie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80200-6
更新日期:1981-10-01 00:00:00
abstract::The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90238-x
更新日期:1992-02-01 00:00:00
abstract::We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.010
更新日期:2015-04-01 00:00:00
abstract::Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.009
更新日期:2005-08-01 00:00:00
abstract::The outcomes of patients with stage I non-small-cell lung cancer (NSCLC) vary greatly, with a 5-year survival rate of approximately 60%. This study evaluated a number of molecular markers that may aid in predicting prognosis in stage I NSCLC after surgical resection. Immunohistochemical (IHC) staining of p53, HER-2/ne...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30183
更新日期:2002-01-01 00:00:00
abstract::Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90251-3
更新日期:1997-10-01 00:00:00
abstract::Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90124-7
更新日期:1999-04-01 00:00:00
abstract::A young male with Buerger's disease who had previously required a left leg amputation died in renal failure and sepsis. Postmortem examination revealed an obliterative lesion of the celiac artery, which resulted in hepatic, splenic, and pancreatic infarctions. Celiac artery involvement represents an unusual manifestat...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(79)80080-5
更新日期:1979-01-01 00:00:00
abstract::Recently, the fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target. We investigated the prevalence of anaplastic lymphoma kinase protein expression in these tumors by immunohistochemistry and correlated the results with data from ALK molecular studies. Gen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.01.012
更新日期:2009-08-01 00:00:00
abstract::Twenty-five uterine stromal neoplasms (five stromal nodules and 12 low-grade and eight high-grade stromal sarcomas) were studied to determine the correlation between clinicopathologic features, flow cytometric tumor DNA content and proliferative fraction, and patient outcome. Fifteen of the 20 sarcomas (five of them h...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90179-s
更新日期:1991-09-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many tumors, but data for primary neuroendocrine carcinoma (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prog...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.51
更新日期:2003-01-01 00:00:00
abstract::Metanephric stromal tumors (MSTs) are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors, along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.025
更新日期:2017-02-01 00:00:00
abstract::Aberrant expression of the antiapoptotic protein BCL (B-cell lymphoma)-2 in neoplastic germinal centers is one of the diagnostic hallmarks of follicular lymphoma. If BCL-2 cannot be detected by immunohistochemistry, the distinction between florid follicular hyperplasia and follicular lymphoma might become a diagnostic...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2011.05.018
更新日期:2012-03-01 00:00:00
abstract::NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.031
更新日期:2018-12-01 00:00:00
abstract::In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.04.010
更新日期:2016-09-01 00:00:00
abstract::Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.017
更新日期:2011-12-01 00:00:00
abstract::SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human mal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.28244
更新日期:2001-10-01 00:00:00
abstract::Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series h...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.05.015
更新日期:2016-10-01 00:00:00
abstract::Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic ca...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.11.011
更新日期:2006-03-01 00:00:00
abstract::Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80279-3
更新日期:1985-10-01 00:00:00
abstract::No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.03.013
更新日期:2017-06-01 00:00:00
abstract::Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cell...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.05.026
更新日期:2016-11-01 00:00:00
abstract::Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.039
更新日期:2017-03-01 00:00:00
abstract::Follicular lymphoma with MYC and BCL2 translocations, so-called double-hit follicular lymphoma (DH-FL), is rare. Here, we report the clinicopathological features of 7 cases of DH-FL. All neoplasms had a follicular pattern (1 partially diffuse). Five cases were predominantly low grade, 4 of which had focal (≤20%) grade...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2016.07.025
更新日期:2016-12-01 00:00:00
abstract::Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.06.019
更新日期:2008-03-01 00:00:00
abstract::Kidneys from 1864 necropsies performed in Brisbane, Australia, and from 397 necropsies performed in Christchurch, New Zealand, were examined macroscopically and microscopically. Three zonal and three focal patterns of renal medullary calcification were defined: (1) Outer medullary cortical calcification seen in hyperc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80057-3
更新日期:1976-07-01 00:00:00
abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90039-3
更新日期:1997-04-01 00:00:00