Abstract：
:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated before, and it is unclear whether these three phenotypically distinct components differ genetically. Each component from all 21 cases was precisely microdissected and examined by microsatellite loss of heterozygosity (LOH) analysis with a panel of 5 microsatellite markers: D2S125, D5S417, D6S297, D6S1577, and D11S1311. In addition, X-chromosome inactivation assay was performed in the components from 18 female cases. The number of microdissected components varied from 2 to 3 depending on the quantity of each cell subpopulation. Histopathological observation indicated that these three components shared an inseparable connection. Identical patterns of X-chromosome inactivation were shared among all the components in 9 of the 11 available informative cases. Of these 9 cases, 5 cases showed partially or totally discordant LOH patterns. Microsatellite analyses revealed discordant LOH patterns in 9 cases, 4 of which were corroborated to have identical X-chromosome inactivation patterns. Concordant LOH patterns were observed in all the components in 3 cases. These data suggest that heterologous components in most mucoepidermoid carcinomas are monoclonally originated. Individual components displayed identical and/or distinct LOH, implying that disparate genetic changes were implicated in the process of phenotypic divergence.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Wang W,Zou B,Zhu H,Bao Ydoi
10.1016/j.humpath.2016.05.022subject
Has Abstractpub_date
2016-10-01 00:00:00pages
114-22eissn
0046-8177issn
1532-8392pii
S0046-8177(16)30105-8journal_volume
56pub_type
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