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Hepatic veno-occlusive disease after high-dose mitomycin C and autologous bone marrow transplantation therapy.

Abstract：

:Three cases of veno-occlusive disease of the liver were diagnosed in four autopsied patients who had received high-dose mitomycin C therapy followed by autologous bone marrow transplantation, and the pathologic finding are reported. Review of 27 liver, examined post mortem, of patients receiving other high-dose chemotherapeutic regimens, 15 of them with subsequent autologous bone marrow transplantation, revealed no evidence of veno-occlusive disease. Veno-occlusive disease may now become a dose-limiting factor in the use of the combined high-dose mitomycin C-bone marrow transplantation therapy. Attention is also drawn to the increasing number of veno-occlusive disease cases being reported in associated with alkylating agents.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Gottfried MR,Sudilovsky O

doi

10.1016/s0046-8177(82)80008-7

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

646-50

issue

7

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(82)80008-7

journal_volume

13

pub_type

杂志文章

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