Abstract：
:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases studied were thus plurihormonal adenomas containing GH and PRL; no pure GH cell adenoma was present. Twenty cases were further examined at the ultrastructural level in conjunction with postembedding double-labeling immunoelectron microscopy; 15 of these cases were diagnosed as mixed GH cell-PRL cell adenomas. The previously diagnosed pure GH cell adenomas possibly may have contained PRL cells and thus should be considered as mixed GH cell-PRL cell adenomas. Mammosomatotroph adenomas were rare in this series. Double-labeling immunoelectron microscopy, using protein A gold particles of two different sizes, greatly facilitated the distinction among GH, PRL, and mammosomatotroph cells.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Furuhata S,Kameya T,Otani M,Toya Sdoi
10.1016/0046-8177(93)90056-msubject
Has Abstractpub_date
1993-01-01 00:00:00pages
10-5issue
1eissn
0046-8177issn
1532-8392pii
0046-8177(93)90056-Mjournal_volume
24pub_type
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