Gleason score 5 + 3 = 8 (grade group 4) prostate cancer-a rare occurrence with contemporary grading.

abstract：:The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...

journal_title：Human pathology

authors： Nishimura S,Tsuda H,Kataoka F,Arao T,Nomura H,Chiyoda T,Susumu N,Nishio K,Aoki D

更新日期：2011-04-01 00:00:00

abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...

journal_title：Human pathology

authors： El-Zimaity HM,Graham DY

更新日期：1999-01-01 00:00:00

abstract：:We compared the DNA content (DI) by cell image analysis with the karyotype and morphological phenotype of paraffin-embedded tissues from 51 spontaneous abortions. The study included 21 cases with triploid, 19 cases with diploid, and 11 cases with aneuploid (monosomic, trisomic, or mosaic) karyotype. Measurements were ...

journal_title：Human pathology

authors： Kaspar HG,Kraemer BB,Kraus FT

更新日期：1998-09-01 00:00:00

abstract：:Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6, p63, GATA3, mammag...

journal_title：Human pathology

authors： Piris A,Peng Y,Boussahmain C,Essary LR,Gudewicz TM,Hoang MP

更新日期：2014-02-01 00:00:00

abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

journal_title：Human pathology

authors： Velez N,Jukic D,Ho J

更新日期：2008-09-01 00:00:00

abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...

journal_title：Human pathology

authors： Schaeffer DF,Walsh JC,Kirsch R,Waterman M,Silverberg MS,Riddell RH

更新日期：2014-09-01 00:00:00

abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

journal_title：Human pathology

authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

更新日期：2010-03-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) status is useful for predicting response to trastuzumab. Fluorescence in situ hybridization (FISH) for HER2 gene amplification is accurate but limited because of cost, the need for fluorescence microscopy, the limited assessment of histology, and the fading of its signal...

journal_title：Human pathology

authors： Lim SJ,Cantillep A,Carpenter PM

更新日期：2013-11-01 00:00:00

abstract：:The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...

journal_title：Human pathology

authors： Abdul-Karim FW,el-Naggar AK,Joyce MJ,Makley JT,Carter JR

更新日期：1992-07-01 00:00:00

abstract：:Endometrial carcinoma is the most common invasive malignancy of the female genital tract, and it exists as two different clinicopathologic forms: an estrogen-dependent, "usual" type and an estrogen-independent "special variant" type. Despite the frequency of endometrial cancer, little is known about the molecular gene...

journal_title：Human pathology

authors： Tritz D,Pieretti M,Turner S,Powell D

更新日期：1997-05-01 00:00:00

abstract：:Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic malignancy and is one of the best understood neoplasms, with relatively well-defined pathogenetic pathways, natural history, and tumor biology. Conventional clinical and pathologic parameters are widely used to grade and stage t...

journal_title：Human pathology

authors： Cheng L,Zhang S,MacLennan GT,Williamson SR,Lopez-Beltran A,Montironi R

更新日期：2011-04-01 00:00:00

abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...

journal_title：Human pathology

authors： Kaluza V,Rao DS,Said JW,de Vos S

更新日期：2006-06-01 00:00:00

abstract：:Although adipophilin has been reported to be a sensitive marker for sebaceous carcinoma, others have noted its expression in squamous cell carcinoma and a variety of noncutaneous tumors, suggesting that lipid droplet accumulation is a frequent feature of neoplastic cells. We investigated the expression of adipophilin ...

journal_title：Human pathology

authors： Boussahmain C,Mochel MC,Hoang MP

更新日期：2013-09-01 00:00:00

abstract：:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...

journal_title：Human pathology

authors： Zhao D,Wang SH,Feng Y,Hua CG,Zhao J,Tang XF

更新日期：2011-10-01 00:00:00

abstract：:A 41 year old woman was treated for metrorrhagia with Ovral three times daily for one week, followed by a single daily dose for one month. Hysterectomy and bilateral salpingo-oophorectomy were performed. Histologically the mucosa of both fallopian tubes had large areas of decidual reaction underlying atrophic epitheli...

journal_title：Human pathology

authors： Mills SE,Fechner RE

更新日期：1980-09-01 00:00:00

abstract：:Lymphocytic colitis (LC) and LC incomplete (LCi) are common causes of chronic watery diarrhea. The diagnosis relies on clinical findings and histopathologic evaluation. The diagnostic criteria of LC are based on hematoxylin and eosin (HE) staining. However, supplementary immunohistochemical staining for highlighting t...

journal_title：Human pathology

authors： Fiehn AK,Clausen LN,Engel U,Wildt S,Munck LK,Kristensson M,Engel PJH

更新日期：2019-02-01 00:00:00

abstract：:It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...

journal_title：Human pathology

authors： Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL

更新日期：2013-05-01 00:00:00

abstract：:Oncogenes, growth factors, cell surface receptors, and cell-cycle and apoptotic regulatory proteins have been implicated in the growth regulation and progression of Barrett's-associated neoplasia. Among these, insulin-like growth factor 1 receptor (IGF1-R) and c-Src are reported to be key regulators of mitogenesis and...

journal_title：Human pathology

authors： Iravani S,Zhang HQ,Yuan ZQ,Cheng JQ,Karl RC,Jove R,Coppola D

更新日期：2003-10-01 00:00:00

abstract：:Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of p...

journal_title：Human pathology

authors： Karnik T,Ozawa MG,Lefterova M,Luna-Fineman S,Alvarez E,Link M,Zehnder JL,Arber DA,Ohgami RS

更新日期：2015-04-01 00:00:00

abstract：:Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...

journal_title：Human pathology

authors： Schenka AA,Gascoyne RD,Duchayne E,Delsol G,Brousset P

更新日期：2003-08-01 00:00:00

abstract：:To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...

journal_title：Human pathology

authors： Kim KM,Valigorsky JM,Mergner WJ,Jones RT,Pendergrass RF,Trump BF

更新日期：1976-01-01 00:00:00

abstract：:Clinicopathological studies of 181 patients with liver cirrhosis undergoing autopsy in the pathology department of a municipal hospital between 1973 and 1976 are reported. The main etiological types were alcoholic (25.4 per cent), HBsAg positive (14.9 per cent), and cryptogenic cirrhosis (54.7 per cent). Four patients...

journal_title：Human pathology

authors： Bartók I,Remenár,Tóth J,Duschanek P,Kanyár B

更新日期：1981-09-01 00:00:00

abstract：:Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis, as manifested by a low incidence of lymph node metastases and an excellent overall survival. It is unknown whether this subtype represents an early step along t...

journal_title：Human pathology

authors： Waldman FM,Hwang ES,Etzell J,Eng C,DeVries S,Bennington J,Thor A

更新日期：2001-02-01 00:00:00

abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...

journal_title：Human pathology

authors： Canet B,Pons C,Espinosa I,Prat J

更新日期：2012-05-01 00:00:00

abstract：:The outcomes of patients with stage I non-small-cell lung cancer (NSCLC) vary greatly, with a 5-year survival rate of approximately 60%. This study evaluated a number of molecular markers that may aid in predicting prognosis in stage I NSCLC after surgical resection. Immunohistochemical (IHC) staining of p53, HER-2/ne...

journal_title：Human pathology

authors： Han H,Landreneau RJ,Santucci TS,Tung MY,Macherey RS,Shackney SE,Sturgis CD,Raab SS,Silverman JF

更新日期：2002-01-01 00:00:00

abstract：:Although the therapeutic outcome of osteosarcoma patients has improved dramatically within the last 20 years because of combined neoadjuvant chemotherapy and surgery, the problem of drug resistance remains. Thus far, markers that can predict the response to chemotherapy at the time of biopsy are not available. Heat sh...

journal_title：Human pathology

authors： Trieb K,Lechleitner T,Lang S,Windhager R,Kotz R,Dirnhofer S

更新日期：1998-10-01 00:00:00

abstract：:A unique case of primary papillary hyperplasia of the gallbladder and cystic and common bile ducts occurring in a young female without calculi, ulcerative colitis, or primary sclerosing cholangitis is reported. The papillary lesion involved the mucosa of the entire gallbladder and of the cystic and common bile ducts. ...

journal_title：Human pathology

authors： Albores-Saavedra J,Defortuna SM,Smothermon WE

更新日期：1990-02-01 00:00:00

abstract：:Strategies for cost containment in the clinical laboratory have been proposed and some are being tested. An approach is described and illustrated in this article for estimating the size of a cost reduction that might be observed in response to hypothetical changes in the utilization of the clinical laboratory. The var...

journal_title：Human pathology

authors： Finkelstein SN

更新日期：1980-09-01 00:00:00

abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...

journal_title：Human pathology

authors： Cornejo KM,Cheng L,Church A,Wang M,Jiang Z

更新日期：2016-03-01 00:00:00

abstract：:This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...

journal_title：Human pathology

authors： Weissman IL,Warnke R,Butcher EC,Rouse R,Levy R

更新日期：1978-01-01 00:00:00