Abstract:
:A unique case of primary papillary hyperplasia of the gallbladder and cystic and common bile ducts occurring in a young female without calculi, ulcerative colitis, or primary sclerosing cholangitis is reported. The papillary lesion involved the mucosa of the entire gallbladder and of the cystic and common bile ducts. Histologically, the gallbladder mucosal folds were close to one another and taller than normal. They were lined by normal-appearing columnar cells and pencil-like cells. The papillary projections of the common bile duct were lined only by columnar cells with prominent subnuclear vacuoles. No endocrine cells or cytologic atypia were noted. The differential diagnoses, including secondary hyperplasia, multiple adenomas, and papillomatosis of the gallbladder, are discussed.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Albores-Saavedra J,Defortuna SM,Smothermon WEdoi
10.1016/0046-8177(90)90134-qsubject
Has Abstractpub_date
1990-02-01 00:00:00pages
228-31issue
2eissn
0046-8177issn
1532-8392pii
0046-8177(90)90134-Qjournal_volume
21pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.009
更新日期:2005-12-01 00:00:00
abstract::Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.08.017
更新日期:2015-01-01 00:00:00
abstract::Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.01.021
更新日期:2013-08-01 00:00:00
abstract::Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.08.004
更新日期:2012-05-01 00:00:00
abstract::The clinical, pathologic, and immunologic features in nine cases of non-Hodgkin's lymphoma of the multilobated B-cell type are described. Clinical and phenotypic heterogeneity was observed in these B-cell neoplasms. A probable follicular center cell derivation for these cytologically unusual B-cell lymphomas is suppor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80131-9
更新日期:1986-06-01 00:00:00
abstract::Rhabdomyomas are rare tumors that usually arise within the heart, orocervical, or vulvovaginal regions. The cardiac tumors have a characteristic immature morphology, occur often in association with tuberous sclerosis, and are regarded as hamartomas rather than true neoplasms. The histogenesis of the extracardiac tumor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90050-6
更新日期:1989-04-01 00:00:00
abstract::In this autopsy series of cryptococcal meningoencephalitis (CME), the authors analyzed neuropathologic lesions in 13 human immunodeficiency virus (HIV) and 14 non-HIV-related cases. Most non-HIV patients did not have immunosuppressive predisposing illness. Analysis of pathological findings revealed significant differe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90459-1
更新日期:1996-08-01 00:00:00
abstract::Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80100-7
更新日期:1977-11-01 00:00:00
abstract::Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90084-t
更新日期:1993-04-01 00:00:00
abstract::The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.11.002
更新日期:2012-09-01 00:00:00
abstract::A membrane-bound, Ca2-dependent complex of the cofactor factor Va and the enzyme factor Xa comprises the prothrombinase coagulation complex, which catalyzes the proteolytic conversion of prothrombin to thrombin. In normal hemostasis, the platelet is presumed to supply the surface membrane and thus constitutes the site...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80334-9
更新日期:1987-02-01 00:00:00
abstract::Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.001
更新日期:2016-12-01 00:00:00
abstract::Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90292-w
更新日期:1991-07-01 00:00:00
abstract::Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.23523
更新日期:2001-04-01 00:00:00
abstract::HMGB2 is an important protein in carcinogenesis. However, little is known about the specific role of HMGB2 in gastric cancer. In the present study, HMGB2 expression was evaluated in 198 primary gastric cancer tissues and their adjacent nontumor controls. The correlation between HMGB2 expression and clinico-pathologica...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.09.017
更新日期:2019-02-01 00:00:00
abstract::Benign lymphocytic angiitis and granulomatosis is a T-cell lymphoproliferative disorder confined to the lung and corresponding to a low-grade angiocentric immunoproliferative lesion. Controversy remains as to whether these lesions are lymphomas. We report such a case in an 8-year-old patient with Burkitt's lymphoma in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90041-z
更新日期:1992-10-01 00:00:00
abstract::Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells attach to extracellular matrix proteins. Focal adhesion kinase interacts with multiple signaling and adaptor molecules and effects several signaling pathways. O...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.024
更新日期:2006-01-01 00:00:00
abstract::Mucin core proteins (MUCs) are expressed in tissue-specific patterns in the gastrointestinal tract and expression is deregulated in Barrett's metaplasia. Based on differential expression, MUCs have been used to classify adenocarcinomas into distinct phenotypes (eg, intestinal, gastric, pancreaticobiliary, etc). Becaus...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.020
更新日期:2014-03-01 00:00:00
abstract::We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30185
更新日期:2002-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.05.020
更新日期:2007-09-01 00:00:00
abstract::Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80287-9
更新日期:1988-11-01 00:00:00
abstract::Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.06.011
更新日期:2012-04-01 00:00:00
abstract::The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.11.022
更新日期:2019-04-01 00:00:00
abstract::Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Und...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(83)80006-9
更新日期:1983-06-01 00:00:00
abstract::Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90267-k
更新日期:1993-12-01 00:00:00
abstract::Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 1...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.21141
更新日期:2001-01-01 00:00:00
abstract::Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.05.001
更新日期:2018-09-01 00:00:00
abstract::Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80169-7
更新日期:1987-04-01 00:00:00
abstract::We investigated the use of remote video microscopy (telepathology) to assist in the diagnosis of 52 neurosurgical frozen section cases. The TelMed system (Discovery Medical Systems, Overland Park, KS), in which the referring pathologist selects appropriate fields for transmission to the consultant, was used for the st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90142-4
更新日期:1993-08-01 00:00:00
abstract::A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90064-a
更新日期:1992-12-01 00:00:00