Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications.

abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

journal_title：Human pathology

authors： Katz B,Tropé CG,Reich R,Davidson B

更新日期：2015-09-01 00:00:00

abstract：:Cytoplasmic mislocalization of p27 (CDKN1B/KIP1) is caused by activated AKT1 and has been associated with poor prognosis in various cancers. CIMP in colorectal cancer is characterized by extensive promoter methylation and is associated with MSI-MSI-H and BRAF mutations. We have recently shown a positive correlation be...

journal_title：Human pathology

authors： Ogino S,Kawasaki T,Ogawa A,Kirkner GJ,Loda M,Fuchs CS

更新日期：2007-04-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumor is a malignant tumor showing nerve sheath differentiation. Approximately one-half of malignant peripheral nerve sheath tumors arise from a benign peripheral nerve sheath tumor, which is commonly a neurofibroma in patients with neurofibromatosis type 1. Malignant peripheral nerve...

journal_title：Human pathology

authors： Endo M,Yamamoto H,Harimaya K,Kohashi K,Ishii T,Setsu N,Iwamoto Y,Oda Y

更新日期：2013-12-01 00:00:00

abstract：:The reticulin stain is a critical diagnostic aide used to differentiate benign hepatocellular proliferations from well differentiated hepatocellular carcinoma (HCC). Rarely, however, hepatocellular carcinomas do not show definitive loss of reticulin in liver biopsy specimens. To study this group of tumors, 11 HCC with...

journal_title：Human pathology

authors： Yasir S,Chen ZE,Said S,Wu TT,Torbenson M

更新日期：2021-01-01 00:00:00

abstract：:The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...

journal_title：Human pathology

authors： Urso C,Borgognoni L,Saieva C,Ferrara G,Tinacci G,Begliomini B,Reali UM

更新日期：2006-07-01 00:00:00

abstract：:Cancer cells show a higher rate of anaerobic respiration than normal cells. The exact mechanisms for this higher glycolysis rate in cancer cells remain to be elucidated. The results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulatio...

journal_title：Human pathology

authors： Won KY,Lim SJ,Kim GY,Kim YW,Han SA,Song JY,Lee DK

更新日期：2012-02-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a commonly occurring tumor in southern China. Although several causative factors have now been recognized, the genetic basis underlying its tumorigenesis is still unclear. To identify potential chromosomal aberrations for further investigations, comparative genomic hybridization (CGH)...

journal_title：Human pathology

authors： Fan CS,Wong N,Leung SF,To KF,Lo KW,Lee SW,Mok TS,Johnson PJ,Huang DP

更新日期：2000-02-01 00:00:00

abstract：:Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...

journal_title：Human pathology

authors： Takeshita M,Ohshima K,Akamatsu M,Ohgami A,Kikuchi M,Suzumiya J,Uike N,Okamura T,Nakayama J

更新日期：1995-06-01 00:00:00

abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...

journal_title：Human pathology

authors： Wang J,Li G,Ma H,Bao Y,Wang X,Zhou H,Sheng Z,Sugimura H,Jin J,Zhou X

更新日期：2007-11-01 00:00:00

abstract：:We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required t...

journal_title：Human pathology

authors： Furudoï A,Caumont C,Dutriaux C,Cappellen D,Goussot JF,Vergier B,Merlio C,Barberis C,Merlio JP,Gros A

更新日期：2016-02-01 00:00:00

abstract：:The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblas...

journal_title：Human pathology

authors： Akmal SN,Yun K,MacLay J,Higami Y,Ikeda T

更新日期：1995-08-01 00:00:00

abstract：:Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy with a poor prognosis, and pathologically, it is a diagnosis of exclusion. Rendering this diagnosis can be challenging in practice because of the large number of diverse entities in the differential diagnosis. We encountered an index case of a sin...

journal_title：Human pathology

authors： Baraban E,Tong CCL,Adappa ND,Cooper K

更新日期：2020-07-01 00:00:00

abstract：:Immunofluorescence of formalin-fixed, paraffin-embedded tissues was performed to study the plasma cell population in 114 colonic specimens from 58 patients. Correlation of the histopathologic stage of disease activity with the isotypes and numbers of immunoglobulin-containing cells in the lamina propria demonstrated h...

journal_title：Human pathology

authors： Keren DF,Appelman HD,Dobbins WO 3rd,Wells JJ,Whisenant B,Foley J,Dieterle R,Geisinger K

更新日期：1984-08-01 00:00:00

abstract：:We describe a case of simultaneous nodular sclerosing Hodgkin's disease and a granulocytic sarcoma in a cervical lymph node without any previous therapy. The condition evolved into acute myelogenous leukemia approximately 8 months after the initial diagnosis of the granulocytic sarcoma. The unexpected presence of a gr...

journal_title：Human pathology

authors： Suh YK,Shin SS,Koo CH

更新日期：1996-10-01 00:00:00

abstract：:Focal calcification is an occasional tubular abnormality seen in minimal-change nephrotic syndrome. Nephrocalcinosis was also reported in premature infants as a consequence of hypercalciuria resulting from long-term furosemide therapy. We describe 4 nephrotic children (3 minimal change, 1 diffuse proliferative glomeru...

journal_title：Human pathology

authors： Mocan H,Yildiran A,Camlibel T,Kuzey GM

更新日期：2000-11-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...

journal_title：Human pathology

authors： Kowalski PJ,Paulino AF

更新日期：2002-09-01 00:00:00

abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...

journal_title：Human pathology

authors： Okoye MI,Watanabe I

更新日期：1982-12-01 00:00:00

abstract：:Cell adhesion molecule expression has been linked to disease outcome in prostatic adenocarcinomas (PACs). We evaluated the coordinated expression of catenin-related proteins, E-cadherin, N-cadherin, and CD44s in PACs. Archival sections from 112 PACs were immunostained by an automated method (Ventana Medical Systems, T...

journal_title：Human pathology

authors： Kallakury BV,Sheehan CE,Ross JS

更新日期：2001-08-01 00:00:00

abstract：:SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human mal...

journal_title：Human pathology

authors： Sakai N,Baba M,Nagasima Y,Kato Y,Hirai K,Kondo K,Kobayashi K,Yoshida M,Kaneko S,Kishida T,Kawakami S,Hosaka M,Inayama Y,Yao M

更新日期：2001-10-01 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

更新日期：2018-01-01 00:00:00

abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...

journal_title：Human pathology

authors： Wang R,Yu Z,Chen F,Liao C,Wang Q,Huang X

更新日期：2018-03-01 00:00:00

abstract：:Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...

journal_title：Human pathology

authors： Papadimitriou JC,Drachenberg CB,Brenner DS,Newkirk C,Trump BF,Silverberg SG

更新日期：2000-12-01 00:00:00

abstract：:Trefoil factors are wound-healing peptides important in protection and healing of the human gastrointestinal tract. Their potential for therapy of gastrointestinal ulcers has been established. This study investigated the hypothesis that trefoil factors are also present in human salivary gland. Tissues from surgical bi...

journal_title：Human pathology

authors： Devine DA,High AS,Owen PJ,Poulsom R,Bonass WA

更新日期：2000-04-01 00:00:00

abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...

journal_title：Human pathology

authors： Esposito S,Valente G,Zavallone A,Guidali P,Rapa A,Oderda G

更新日期：2004-01-01 00:00:00

abstract：:The aim of the study was to evaluate the impact of the updated 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline on human epidermal growth factor receptor 2 (HER2) interpretation in breast cancer compared with that of the previous guidelines and also the significance of...

journal_title：Human pathology

authors： Woo JW,Lee K,Chung YR,Jang MH,Ahn S,Park SY

更新日期：2020-04-01 00:00:00

abstract：:Fibroepithelial lesions (FEL) of the breast are notoriously difficult to classify on core needle biopsies. The goal of this study was to evaluate interobserver variability and accuracy of subclassifying difficult FELs into fibroadenoma (FA) and phyllodes tumors (PTs). We identified 50 breast core needle biopsies, init...

journal_title：Human pathology

authors： Bandyopadhyay S,Barak S,Hayek K,Thomas S,Saeed H,Beydoun R,Shi D,Arabi H,Ruterbusch J,Cote M,Ali-Fehmi R

更新日期：2016-01-01 00:00:00

abstract：:To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...

journal_title：Human pathology

authors： Sasano H,Suzuki T,Nagura H,Nishikawa T

更新日期：1993-04-01 00:00:00

abstract：:Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...

journal_title：Human pathology

authors： Oyer CE,Cai R,Coughlin JJ,Singer DB

更新日期：1998-01-01 00:00:00

abstract：:A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...

journal_title：Human pathology

authors： Baněčková M,Martínek P,Skálová A,Mezencev R,Hadravský L,Michal M,Švajdler M

更新日期：2020-05-01 00:00:00

abstract：:In the past decade most studies of coronary arterial aneurysms have been clinical; few have focused on morphology and etiopathogenesis. The subjects of the present autopsy study were 52 patients, 5 months to 80 years of age, with coronary arterial aneurysms. Patients were divided into two groups: 38 with atherosclerot...

journal_title：Human pathology

authors： Virmani R,Robinowitz M,Atkinson JB,Forman MB,Silver MD,McAllister HA

更新日期：1986-06-01 00:00:00