Clinicopathological and molecular features of SF3B1-mutated myeloproliferative neoplasms.

abstract：:Hypertrophic cardiomyopathy phenotype is shared by heterogeneous entities. The purpose of the study was to evaluate the diagnostic role of left ventricular endomyocardial biopsy. One hundred fifty-one consecutive patients with unexplained left ventricular hypertrophy and normal/elevated QRS voltages or left bundle-bra...

journal_title：Human pathology

authors： Frustaci A,Russo MA,Chimenti C

更新日期：2013-01-01 00:00:00

abstract：:Many have wondered what might have become of the totalitarian state Lenin founded on merciless terror, had he not died so young. He was 52 and at the height of his power when he had his first stroke. Six months later he had another and then a third stroke three months after that. He died 3 months shy of his 54th birth...

journal_title：Human pathology

authors： Vinters H,Lurie L,Mackowiak PA

更新日期：2013-10-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...

journal_title：Human pathology

authors： Ni H,Zhang XP,Wang XT,Xia QY,Lv JH,Wang X,Shi SS,Li R,Zhou XJ,Rao Q

更新日期：2016-12-01 00:00:00

abstract：:Benign chondroblastoma is an unusual solitary bone tumor occurring usually in the second decade in a long bone. The tumor is often sited on epiphyseal cartilages. Very few examples of malignant variants have been documented, although local recurrence of benign tumors is not unusual. We wish to report a patient who dev...

journal_title：Human pathology

authors： Roberts PF,Taylor JG

更新日期：1980-05-01 00:00:00

abstract：:Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

journal_title：Human pathology

authors： Veinot JP,Gattinger DA,Fliss H

更新日期：1997-04-01 00:00:00

abstract：:Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlations are known for some established forms of GBOC; however, whether su...

journal_title：Human pathology

authors： Schoolmeester JK,Moyer AM,Goodenberger ML,Keeney GL,Carter JM,Bakkum-Gamez JN

更新日期：2017-12-01 00:00:00

abstract：:Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombot...

journal_title：Human pathology

authors： Kraus FT

更新日期：1997-02-01 00:00:00

abstract：:The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...

journal_title：Human pathology

authors： Skaland I,van Diest PJ,Janssen EA,Gudlaugsson E,Baak JP

更新日期：2008-04-01 00:00:00

abstract：:Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...

journal_title：Human pathology

authors： Tan J,Sidhu G,Greco MA,Ballard H,Wieczorek R

更新日期：1998-04-01 00:00:00

abstract：:Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung aden...

journal_title：Human pathology

authors： Sturm N,Lantuéjoul S,Laverrière MH,Papotti M,Brichon PY,Brambilla C,Brambilla E

更新日期：2001-09-01 00:00:00

abstract：:In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...

journal_title：Human pathology

authors： Clark JL,Lu D,Kalir T,Liu Y

更新日期：2016-09-01 00:00:00

abstract：:Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...

journal_title：Human pathology

authors： Ro JY,Silva EG,Gallager HS

更新日期：1987-12-01 00:00:00

abstract：:Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...

journal_title：Human pathology

authors： Turbat-Herrera EA,Knowles K

更新日期：1998-12-01 00:00:00

abstract：:Decreases in true expenses in the hospital clinical laboratory consequent to reduced utilization were estimated from four models. Each category of direct expense was adjusted according to projections and confirmed to the extent possible by actual experience. No projections of reductions in indirect expenses were made....

journal_title：Human pathology

authors： Winkelman JW

更新日期：1984-06-01 00:00:00

abstract：:Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...

journal_title：Human pathology

authors： Ragsdale BD

更新日期：1993-05-01 00:00:00

abstract：:Endometrioid endometrial carcinomas (EECs) are correlated with high serum levels of androgens and estrogen. We hypothesized that Leydig cells and ovarian stromal hyperplasia contribute to postmenopausal ovarian androgen production and are observed more frequently in EEC patients. Ovaries of postmenopausal women with E...

journal_title：Human pathology

authors： Reijnen C,Küsters-Vandevelde HVN,Abbink K,Zusterzeel PLM,van Herwaarden AE,van der Laak JAWM,Massuger LFAG,Snijders MPLM,Pijnenborg JMA,Bulten J

更新日期：2019-03-01 00:00:00

abstract：:Molecular apocrine breast cancer (MABC) is a molecular subtype with a poor prognosis, and there is urgent need to find new therapeutic targets. Epidermal growth factor receptor (EGFR) plays an important part in regulating the biological behavior of tumor cells, and EGFR-targeted drugs have already been used in therapy...

journal_title：Human pathology

authors： Liu X,Feng C,Liu J,Liu J,Li C,Xu C,Niu Y

更新日期：2018-07-01 00:00:00

abstract：:Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...

journal_title：Human pathology

authors： de Freitas RS,Dantas KC,Garcia RS,Magri MM,de Andrade HF Jr

更新日期：2010-09-01 00:00:00

abstract：:Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...

journal_title：Human pathology

authors： Lauwers GY,Grant LD,Scott GV,Carr NJ,Sobin LH

更新日期：1998-08-01 00:00:00

abstract：:Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...

journal_title：Human pathology

authors： Said S,Kurtin PJ,Nasr SH,Graham RP,Dasari S,Vrana JA,Yasir S,Torbenson MS,Zhang L,Mounajjed T,Eric Chen ZM,Lee HE,Wu TT

更新日期：2020-09-01 00:00:00

abstract：:The case of a biliary cystadenoma containing foci of cystadenocarcinoma is reported, along with the first electron microscopic description of this lesion. Both neoplastic and congenital origins have been implicated in the pathogenesis of biliary cystadenomas. In this case hamartomatous bile ducts were found, supportin...

journal_title：Human pathology

authors： Devine P,Ucci AA

更新日期：1985-01-01 00:00:00

abstract：:The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic ...

journal_title：Human pathology

authors： Bauman TM,Vezina CM,Ricke EA,Halberg RB,Huang W,Peterson RE,Ricke WA

更新日期：2016-05-01 00:00:00

abstract：:Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer; however, clinicopathological featur...

journal_title：Human pathology

authors： Iida Y,Masuda S,Nakanishi Y,Shimizu T,Nishimaki H,Takahashi M,Hikichi M,Maruoka S,Gon Y,Takahashi N,Hashimoto S

更新日期：2018-09-01 00:00:00

abstract：:Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle c...

journal_title：Human pathology

authors： Gaffney EF,Majmudar B,Hewan-Lowe K

更新日期：1984-02-01 00:00:00

abstract：:The expression of the proteins encoded by the ras, myc, and erb B-2 oncogenes was examined in 63 paraffin-embedded human cholangiocarcinomas of Thai and English origin using immunohistochemistry. The observed distributions were compared with oncogene expression in a series of human hepatocellular carcinomas. In an att...

journal_title：Human pathology

authors： Voravud N,Foster CS,Gilbertson JA,Sikora K,Waxman J

更新日期：1989-12-01 00:00:00

abstract：:Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chr...

journal_title：Human pathology

authors： Doss BJ,Greene MF,Hill J,Heffner LJ,Bieber FR,Genest DR

更新日期：1995-11-01 00:00:00

abstract：:We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...

journal_title：Human pathology

authors： Wobker SE,Zhong M,Epstein JI

更新日期：2017-01-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end-stage renal disease in children and young adults. Approximately 60% of patients with a known genetic etiology of nephronophthisis are due to homozygous deletion of the NPHP1 gene. We identified a total o...

journal_title：Human pathology

authors： Larsen CP,Bonsib SM,Beggs ML,Wilson JD

更新日期：2018-11-01 00:00:00

abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...

journal_title：Human pathology

authors： Wei Q,Zhou H,Zhong L,Shi L,Liu J,Yang Q,Zhao T

更新日期：2017-06-01 00:00:00

abstract：:A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...

journal_title：Human pathology

authors： Urbanski SJ,Medline A

更新日期：1982-11-01 00:00:00