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Clinicopathological characteristics of thyroid transcription factor 1-negative small cell lung cancers.

Abstract：

:Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer; however, clinicopathological features of TTF-1-negative SCLC remain unclear. This study aimed to elucidate the characteristics of TTF-1-negative SCLC. We studied the associations between the expression of TTF-1 and the clinicopathological factors associated with SCLC, including survival and expression of neuroendocrine markers (synaptophysin, chromogranin A, and CD56), neuroendocrine cell-specific transcription factors (ASCL1, BRN2), a proliferation marker (Ki-67 labeling index), and an oncogene (NF1B). Formalin-fixed and paraffin-embedded sections of SCLC tumors were subjected to immunohistochemistry and quantitative reverse-transcription polymerase chain reaction analyses. In a case-control cohort matched for basic clinical factors, expression of ProGRP, synaptophysin, chromogranin A, and ASCL1 was significantly decreased in TTF-1-negative SCLC samples. In contrast, there was no significant correlation between Ki-67 labeling index and TTF-1. In a larger serial case cohort, TTF-1-negative SCLC cases were older at diagnosis, but there was no significant difference in the overall survival of patients with TTF-1-negative and TTF-1-positive SCLC. In conclusion, TTF-1-negative SCLC showed decreased neuroendocrine differentiation, and significantly worse clinical outcomes were not observed.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Iida Y,Masuda S,Nakanishi Y,Shimizu T,Nishimaki H,Takahashi M,Hikichi M,Maruoka S,Gon Y,Takahashi N,Hashimoto S

doi

10.1016/j.humpath.2018.05.009

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

127-134

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(18)30167-9

journal_volume

79

pub_type

杂志文章

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