Abstract:
:Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Aihara M,Truong LD,Dunn JK,Wheeler TM,Scardino PT,Thompson TCdoi
10.1016/0046-8177(94)90249-6subject
Has Abstractpub_date
1994-08-01 00:00:00pages
797-801issue
8eissn
0046-8177issn
1532-8392pii
0046-8177(94)90249-6journal_volume
25pub_type
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