Abstract:
:Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with normal Doppler (controls), 47 IUGR fetuses with normal Doppler and 32 IUGR fetuses with abnormal Doppler underwent morphometric analysis using a highly optimized microscope environment (HOME) and "CordHOME" software. IUGR with an accompanying normal Doppler versus control showed a reduction of Wharton jelly and both the total and lumen vein areas. IUGR with an accompanying pathological Doppler showed a comparable reduction in wall thickness and areas of every vessel. These findings indicate that the hypoplastic umbilical vessels are associated with an increase in placental vascular resistance that may be the consequence of underdevelopment in response to a chronic reduction in placental blood flow.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Bruch JF,Sibony O,Benali K,Challier JC,Blot P,Nessmann Cdoi
10.1016/s0046-8177(97)90251-3subject
Has Abstractpub_date
1997-10-01 00:00:00pages
1139-45issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(97)90251-3journal_volume
28pub_type
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