Abstract：
:Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointestinal stromal tumors (GISTs). Twenty-three GISTs (9 low malignant potential, 10 primary malignant, and 4 intra-abdominal recurrences) were evaluated for hTERT expression by using immunohistochemistry on tissue microarray. Tissue blocks were retrieved, and hematoxylin and eosin stains were performed to evaluate the histological tumor type. All cases were strongly positive for KIT (CD117). Immunohistochemistry for hTERT was performed. Eight of 9 cases of the low malignant potential group were negative for hTERT immunoexpression, whereas all malignant GISTs showed positive staining that varied from weak to strong immunoreactivity. Six of 10 cases of the primary malignant GISTs were strongly positive for hTERT. The remaining cases (4/10) showed weak staining. All recurrent GISTs (4/4) showed strong positive immunostaining for hTERT. One malignant case was weakly positive for hTERT, but its recurrence was strongly positive. These results suggest that hTERT expression occurs preferentially in malignant tumors and that telomerase activity may occur during the progression of GISTs. Immunohistochemical staining for hTERT may be a useful marker for the prognostication of GISTs.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Sabah M,Cummins R,Leader M,Kay Edoi
10.1016/j.humpath.2004.07.010subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1231-5issue
10eissn
0046-8177issn
1532-8392pii
S0046817704004137journal_volume
35pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.07.037
更新日期：2013-12-01 00:00:00
abstract：:Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90145-7
更新日期：1994-04-01 00:00:00
abstract：:Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.019
更新日期：2019-01-01 00:00:00
abstract：:Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other typ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80185-x
更新日期：1986-07-01 00:00:00
abstract：:Clusterin has been reported to play a significant role in tumorigenesis, and its overexpression occurs in various human malignancies. We examine the clusterin overexpression in human hepatocellular carcinoma (HCC) and verify its clinical usefulness as a candidate biomarker by clinicopathologic and survival analysis. W...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.021
更新日期：2004-11-01 00:00:00
abstract：:We studied renal tissues from 203 patients with acquired immunodeficiency syndrome (AIDS). Of the 203 patients, 20 showed light-microscopic changes characteristic of AIDS-associated nephropathy (AAN). Fifteen of the 20 (group A) were examined by immunohistochemistry using Mycoplasma fermentans (incognitus strain)-spec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90063-u
更新日期：1991-01-01 00:00:00
abstract：:Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides. Each showed diffuse staining for NSE. Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enk...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80314-9
更新日期：1988-01-01 00:00:00
abstract：:Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90096-l
更新日期：1992-04-01 00:00:00
abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80164-6
更新日期：1983-10-01 00:00:00
abstract：:Plakophilins (PKPs) are members of the armadillo multigene family. Armadillo-related proteins function in both cell adhesion and signal transduction, and also play a central role in tumorigenesis. Here we report the immunohistochemical localization of PKPs in 37 cases of human primary squamous cell carcinoma of the or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00174-6
更新日期：2003-06-01 00:00:00
abstract：:Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2019.09.001
更新日期：2019-12-01 00:00:00
abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.012
更新日期：2006-06-01 00:00:00
abstract：:We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.03.011
更新日期：2012-03-01 00:00:00
abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.08.010
更新日期：2019-11-01 00:00:00
abstract：:Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2015.10.003
更新日期：2016-03-01 00:00:00
abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.021
更新日期：2013-08-01 00:00:00
abstract：:Papillary renal cell carcinoma (P-RCC) is the second most common type of malignant renal epithelial tumor and can be subclassified into type 1, which demonstrates simple cuboidal low-grade epithelium and type 2, which demonstrates pseudostratified high-grade epithelium with abundant eosinophilic cytoplasm. Despite thi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.004
更新日期：2014-06-01 00:00:00
abstract：:Intraductal papillary neoplasm of the liver (IPNL) is a precursor lesion of intrahepatic cholangiocarcinoma (ICC) arising in hepatolithiasis. In this study, 98 foci of IPNL identified in 39 surgically resected hepatolithiatic livers were investigated for expression of p16INK4a, cyclin D1, p21WAF1/CIP1, p53, mouse doub...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.08.014
更新日期：2004-12-01 00:00:00
abstract：:The immunohistologic distribution of the basement membrane components, type IV collagen and laminin, was evaluated in 57 alcohol-fixed, paraffin-embedded tissue sections which demonstrated immunostaining patterns with antigen preservation similar to that of frozen tissue sections. Normal and hyperplastic squamous muco...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80221-6
更新日期：1987-10-01 00:00:00
abstract：:Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90145-0
更新日期：1995-04-01 00:00:00
abstract：:Ciliated metaplasia (CM) of gastric mucosa is common in Japanese individuals but rare in whites. We studied 36 consecutive gastrectomies from Chinese individuals for the presence of CM. The gastrectomies were performed for adenocarcinoma (n = 22), benign ulcer (n = 13), and malignant lymphoma (n = 1). Ciliated metapla...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90191-i
更新日期：1993-10-01 00:00:00
abstract：:The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80285-5
更新日期：1988-11-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90072-7
更新日期：1998-05-01 00:00:00
abstract：:Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.03.008
更新日期：2014-08-01 00:00:00
abstract：:Deposits found intrauterine contraceptive devices (IUDs) were studied by scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray microanalysis. All seven devices, including five plastic and two copper IUDs, were coated with a crust containing cellular, acellular, and fibrillar material. The cellul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80160-x
更新日期：1985-07-01 00:00:00
abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.011
更新日期：2015-03-01 00:00:00
abstract：:Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.10.020
更新日期：2007-06-01 00:00:00
abstract：:In this report, we present the clinicopathologic features of 13 cases of the invasive micropapillary variant of urothelial carcinoma. This is a rare and aggressive variant of bladder cancer recognized by the current World Health Organization classification of urologic tumors. The micropapillary component varied from 5...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.11.018
更新日期：2010-08-01 00:00:00
