Abstract:
:Ciliated metaplasia (CM) of gastric mucosa is common in Japanese individuals but rare in whites. We studied 36 consecutive gastrectomies from Chinese individuals for the presence of CM. The gastrectomies were performed for adenocarcinoma (n = 22), benign ulcer (n = 13), and malignant lymphoma (n = 1). Ciliated metaplasia was found in 16 (44.4%) of the stomachs, with equal distribution between male and female patients. Ciliated metaplasia was present in 11 cases (50%) of adenocarcinoma and in five cases (38.5%) of benign ulcer, the difference being statistically insignificant. Contrary to previous studies, there was no increased frequency of CM in gastric mucosa harboring an intestinal-type adenocarcinoma compared with those with non-intestinal-type tumors. Ciliated metaplasia always co-existed with intestinal metaplasia. Colonization by Helicobacter pylori was not associated with an increased incidence of CM. In five cases (22.7%) of adenocarcinoma ciliated tumor cells were found, and all of these cases showed CM in the gastric mucosa. In one of these cases the whole tumor was composed of glands formed by ciliated cells. In the other cases there was a morphologically different nonciliated component. The cilia in the tumor cells showed light microscopic and ultrastructural changes identical to those of the cilia seen in CM affecting the nonneoplastic gastric mucosa. This study documents for the first time the co-existence of CM and ciliated adenocarcinoma in the same stomach. It is concluded that in the Hong Kong Chinese population CM is commonly present in gastric mucosa harboring an adenocarcinoma or benign ulcer. Adenocarcinomas with ciliated cells are strongly associated with CM.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Chan WY,Hui PK,Leung KM,Robertson CS,Chung SCdoi
10.1016/0046-8177(93)90191-isubject
Has Abstractpub_date
1993-10-01 00:00:00pages
1107-13issue
10eissn
0046-8177issn
1532-8392pii
0046-8177(93)90191-Ijournal_volume
24pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Sixteen cases of intermediate lymphocytic lymphoma (ILL), including eight cases with mantle zone architecture, were studied using cryostat sections, a biotin-avidin immunoperoxidase technique, and a large panel of monoclonal antibodies. The neoplastic cells invariably expressed IgM, most B lineage antigens (B1, TO15, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80203-x
更新日期:1988-05-01 00:00:00
abstract::The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2007.08.016
更新日期:2008-04-01 00:00:00
abstract::Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained for GATA binding protein 3...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2012.02.011
更新日期:2012-11-01 00:00:00
abstract::Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1053/hupa.2003.35
更新日期:2003-03-01 00:00:00
abstract::Plakophilins (PKPs) are members of the armadillo multigene family. Armadillo-related proteins function in both cell adhesion and signal transduction, and also play a central role in tumorigenesis. Here we report the immunohistochemical localization of PKPs in 37 cases of human primary squamous cell carcinoma of the or...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(03)00174-6
更新日期:2003-06-01 00:00:00
abstract::We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90011-q
更新日期:1992-01-01 00:00:00
abstract::The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.01.001
更新日期:2016-06-01 00:00:00
abstract::Two hundred three testicular germ cell tumors were studied immunohistochemically for the presence of placental alkaline phosphatase (PLAP). Special emphasis was placed on the pattern and incidence of positive staining of intratubular malignant germ cells (ITMGCs) adjacent to tumors. 99% of cases with adjacent ITMGCs s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80172-2
更新日期:1988-06-01 00:00:00
abstract::The aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were evaluated in each case: type of radic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.08.012
更新日期:2019-11-01 00:00:00
abstract::A 41 year old woman was treated for metrorrhagia with Ovral three times daily for one week, followed by a single daily dose for one month. Hysterectomy and bilateral salpingo-oophorectomy were performed. Histologically the mucosa of both fallopian tubes had large areas of decidual reaction underlying atrophic epitheli...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.09.007
更新日期:2020-12-01 00:00:00
abstract::Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80248-8
更新日期:1984-11-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.03.001
更新日期:2020-05-01 00:00:00
abstract::Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.11
更新日期:2003-02-01 00:00:00
abstract::Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.20376
更新日期:2000-12-01 00:00:00
abstract::Congenital cystic airway malformation/congenital pulmonary airway malformation (CCAM/CPAM) of the lung is a rare but well-described malformative lesion of pulmonary parenchyma characterized by the abnormal maturation of airways along with an increase in terminal respiratory structures, resulting in cysts of variable s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.04.009
更新日期:2007-12-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.026
更新日期:2015-10-01 00:00:00
abstract::There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.001
更新日期:2005-11-01 00:00:00
abstract::Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.009
更新日期:2005-12-01 00:00:00
abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.013
更新日期:2010-10-01 00:00:00
abstract::Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.08.010
更新日期:2019-11-01 00:00:00
abstract::Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90277-0
更新日期:1999-02-01 00:00:00
abstract::Increasing differentiation in the human endometrium is associated with an apparent decrease in intercellular contacts between endometrial stromal cells ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90257-6
更新日期:1990-10-01 00:00:00
abstract::Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.009
更新日期:2006-09-01 00:00:00
abstract::Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90422-1
更新日期:1998-10-01 00:00:00
abstract::Two undifferentiated (embryonal) sarcomas of liver were studied ultrastructurally and immunohistochemically. Electron microscopic examination of the pleomorphic tumor cells revealed fibroblastic and histiocytic characteristics. There were no specific findings to support rhabdomyoblastic, leiomyoblastic, or epithelial ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80154-4
更新日期:1985-07-01 00:00:00
abstract::A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2009.06.017
更新日期:2010-03-01 00:00:00
abstract::We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique. A series of 90 cases of human breast carcinoma was ana...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90060-8
更新日期:1995-03-01 00:00:00
abstract::Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2011.07.020
更新日期:2012-04-01 00:00:00