Abstract:
:Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason patterns (GPs). In this regard, the prognostic significance of GP5 in biopsies with highest GrGr4 is uncertain and evaluated in this study. A search of all core biopsies positive for prostate cancer reviewed after 2005 was performed, and 71 cases with highest GrGr4 containing GP5 (i.e., 3 + 5 = 8 or 5 + 3 = 8; referred to as GrGr4/GP5pos) eligible for inclusion were identified. In addition, 95 core biopsy cases with highest GrGr4 and no GP5 (i.e, 4 + 4 = 8; referred to as GrGr4/GP5neg) were selected for comparison. Multiple pathologic parameters, including volume and amount of GP4, and clinical variables were collected to evaluate the influence of GP5 on disease recurrence, development of metastases, and disease-specific death. GrGr4/GP5pos cases did not show, as a group, statistically significant differences in prostatectomy findings, disease recurrence, metastases, and disease-specific mortality when compared with GrGr4/GP5neg cases. In addition, the risk of all outcomes evaluated in the study did not differ between the whole GrGr4/GP5pos and GrGr4/GP5neg groups. However, Kaplan-Meier analysis found that GrGr4/GP5pos cases with a significant amount of GP4 did show a higher risk of prostate cancer-specific death as well as bone and visceral metastases. Univariate Cox regression demonstrated that preoperative prostate specific antigen (PSA), total number of positive cores, and global GrGr5 were also associated with a higher chance of disease-specific death. In a multivariate model, only global GrGr5 and PSA >20 ng/dL remained statistically significant. This study suggests that the mere presence of GP5 in core biopsies with highest GrGr4 disease may not portend a worse prognosis. In these cases, accounting for the case-wide volume of GP4 by reporting a global GrGr appears to be more relevant as it identifies a subset of GrGr4/GP5pos patients with global GrGr5 who have a higher risk of metastases and prostate cancer-specific mortality.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Acosta AM,Taplin ME,Mata DA,D'Amico AV,Hirsch MSdoi
10.1016/j.humpath.2020.03.001subject
Has Abstractpub_date
2020-05-01 00:00:00pages
62-74eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30050-2journal_volume
99pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(99)90040-0
更新日期:1999-10-01 00:00:00
abstract::We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90125-6
更新日期:1995-01-01 00:00:00
abstract::A 57 year old man presented with a two week history of right sided chest pain. An admission chest x-ray examination revealed a 2 by 1 cm. lytic lesion of the ninth right rib and right sided pleural effusion. The patient underwent a right thoracotomy during which 700 cc. of blood tinged pleural fluid was drained and a ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(80)80080-3
更新日期:1980-11-01 00:00:00
abstract::Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.012
更新日期:2004-10-01 00:00:00
abstract::The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90175-2
更新日期:1995-06-01 00:00:00
abstract::Four human fetuses with the limb body wall malformation complex, also known as the amniotic band syndrome, were examined. Besides malformations of the body wall and the limb(s), anomalies of the internal organs were found in three fetuses, suggesting a disturbance of normal morphogenesis before the fifth week of devel...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90225-6
更新日期:1989-11-01 00:00:00
abstract::Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90165-5
更新日期:1995-06-01 00:00:00
abstract::The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.010
更新日期:2011-11-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::Collapsing glomerulopathy (CG), an aggressive variant of focal segmental glomerular sclerosis, is a renal disease with severe proteinuria and rapidly progressive renal failure. The pathogenesis of CG is unknown. It strongly resembles human immunodeficiency virus (HIV)-associated nephropathy, but the patients are HIV n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.124333
更新日期:2002-04-01 00:00:00
abstract::Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.011
更新日期:2019-01-01 00:00:00
abstract::Focal calcification is an occasional tubular abnormality seen in minimal-change nephrotic syndrome. Nephrocalcinosis was also reported in premature infants as a consequence of hypercalciuria resulting from long-term furosemide therapy. We describe 4 nephrotic children (3 minimal change, 1 diffuse proliferative glomeru...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.03.005
更新日期:2006-08-01 00:00:00
abstract::Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.010
更新日期:2015-03-01 00:00:00
abstract::Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.017
更新日期:2013-10-01 00:00:00
abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.009
更新日期:2008-06-01 00:00:00
abstract::Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.09.005
更新日期:2019-02-01 00:00:00
abstract::Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.016
更新日期:2005-09-01 00:00:00
abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90039-3
更新日期:1997-04-01 00:00:00
abstract::Astrocytoma grade IV (glioblastoma multiforme) is the most common and most malignant tumor of the central nervous system and is currently noncurable. Here, we have examined a population-based cohort of 47 patients with grade IV astrocytoma, who underwent tumor surgery at Sahlgrenska University Hospital in Sweden and w...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.013
更新日期:2013-10-01 00:00:00
abstract::Lymphocytic colitis (LC) and LC incomplete (LCi) are common causes of chronic watery diarrhea. The diagnosis relies on clinical findings and histopathologic evaluation. The diagnostic criteria of LC are based on hematoxylin and eosin (HE) staining. However, supplementary immunohistochemical staining for highlighting t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.031
更新日期:2019-02-01 00:00:00
abstract::Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.003
更新日期:2013-10-01 00:00:00
abstract::We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.010
更新日期:2015-04-01 00:00:00
abstract::Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonsemin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.09.007
更新日期:2019-02-01 00:00:00
abstract::Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations pr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.06.003
更新日期:2014-09-01 00:00:00
abstract::A case of a primary carcinoid islet cell tumor of the duodenum is reported, demonstrated by histochemistry, electron microscopy, and immunofluorescence to be composed of alpha cells containing glucagon-like material. The patient was found on admission to have hyperglycemia and a diffuse skin rash. Primary duodenal glu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(79)80032-5
更新日期:1979-05-01 00:00:00
abstract::To ensure appropriate mission-based budgeting and equitable distribution of funds for faculty salaries, our compensation committee developed a pathology-specific effort reporting database. Principles included the following: (1) measurement should be done by web-based databases; (2) most entry should be done by departm...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.033
更新日期:2008-04-01 00:00:00
abstract::Four surgically resected cardiac valves received from three female patients showed the presence of acute and chronic rheumatic valvulitis. The material was studied by means of transmission and scanning electron microscopy. This is the first time that there has been an investigation of the ultrastructure in acute rheum...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(80)80109-2
更新日期:1980-01-01 00:00:00
abstract::Eight cases of primary mesenchymal renal tumor in infants under one year of age were studied. The patients' ages ranged from one day to seven months; all but one were diagnosed within the first three months of life. There were four typical congenital mesoblastic nephromas. Two malignant mesenchymal, one intermediate c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80244-4
更新日期:1981-01-01 00:00:00
abstract::Liver parenchymal cells (hepatocytes) have a low rate of turnover, but can nevertheless mount a rapid and efficient regenerative response. However, in some cases of extreme hepatotoxicity hepatocyte proliferation is restricted or even abolished, and instead biliary epithelial cells, commonly referred to as ductular ov...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(96)90212-9
更新日期:1996-09-01 00:00:00