Abstract:
:Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (range: 2-75) years and a high mortality rate (31/37, 83.8%). Fourteen (35%) patients were diagnosed with hepatosplenic T-cell lymphoma (HSTCL), 13 (32.5%) peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 (32.5%) other types of T-cell neoplasms. Patients with HSTCL were much younger and had worse survival than PTCL-NOS and other T-cell neoplasms (P < 0.05). On imaging studies, 20 cases (50%) showed abnormalities, including 10 with mass lesions that correlated with normal or cholestatic pattern enzyme elevation. Histomorphological analysis revealed four main patterns; with the exception of mass forming lesions (pattern 4; n = 8), cases with sinusoidal predominant (pattern 1; n = 12), portal predominant with sinusoidal infiltrates (pattern 2; n = 13) or lobular aggregates (pattern 3; n = 5) demonstrated small to medium lymphocytes resembling a reactive/inflammatory process. In addition, we described two cases of T-cell large granular lymphocytic leukemia that mimicked HSTCL, and a case of aggressive post-transplant lymphoproliferative disorder that developed after chronic Epstein-barr virus (EBV) infection, suggesting the importance of EBV testing in some lymphoma cases. As the largest cohort of T-cell neoplasms in liver, our study provides critical data on disease frequency, distribution, and clinicopathologic features that are essential for accurate diagnosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Li P,Zhang D,Zhou J,Li P,Shen Y,Pan Z,Evans AG,Liao Xdoi
10.1016/j.humpath.2020.09.007subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1-12eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30179-9journal_volume
106pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00
abstract::The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90175-2
更新日期:1995-06-01 00:00:00
abstract::The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.10.016
更新日期:2015-02-01 00:00:00
abstract::Two episodes of severe, relapsing sensorimotor polyneuropathy closely paralleled the course of systemic illness in a patient with immunoblastic lymphadenopathy. A review of the literature shows three other cases, although none with documented pathologic changes in muscles and nerves. Based on the pathologic findings i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80120-2
更新日期:1982-02-01 00:00:00
abstract::Two undifferentiated (embryonal) sarcomas of liver were studied ultrastructurally and immunohistochemically. Electron microscopic examination of the pleomorphic tumor cells revealed fibroblastic and histiocytic characteristics. There were no specific findings to support rhabdomyoblastic, leiomyoblastic, or epithelial ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80154-4
更新日期:1985-07-01 00:00:00
abstract::In order to study the granular transformation of Sertoli cells the following testicular specimens were reviewed: 58 postmortem biopsies from 21 children and 37 young adult males with normal histologic pattern; 165 biopsies from prepubertal cryptorchid testes; 38 biopsies and 18 surgical specimens from postpubertal-cry...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90034-m
更新日期:1991-02-01 00:00:00
abstract::Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.02.007
更新日期:2009-08-01 00:00:00
abstract::A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.12.002
更新日期:2011-09-01 00:00:00
abstract::Meconium-associated vascular necrosis (MAVN) is a histological abnormality of human placental chorionic vessels that is associated with poor neonatal outcome. We tested the hypothesis that MAVN shows apoptosis in the walls of chorionic vessels. Archival placental specimens with MAVN (n = 5) were compared with specimen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.12.002
更新日期:2004-04-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::The light microscopic diagnosis of large cell undifferentiated carcinoma of the lung is known to be highly subjective and shows poor interobserver reproducibility; the very existence of this tumor as a separate entity has been challenged. The ultrastructure of seven large cell undifferentiated carcinomas was examined ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80105-1
更新日期:1978-03-01 00:00:00
abstract::Reactive bone marrow mast cells reliably lack the morphologic, immunophenotypic, and molecular features of systemic mastocytosis (SM). We report two unusual cases of acquired aplastic anemia (AA) in which multifocal aggregates of bone marrow mast cells fulfilled morphologic and immunophenotypic criteria for SM accordi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.08.002
更新日期:2014-02-01 00:00:00
abstract::AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.12.012
更新日期:2018-03-01 00:00:00
abstract::Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained for GATA binding protein 3...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2012.02.011
更新日期:2012-11-01 00:00:00
abstract::Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.04.039
更新日期:2019-01-01 00:00:00
abstract::B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 subtypes with either somatically mutated or unmutated immunoglobulin heavy-chain variable region (IgVH) genes. A prognostic significance of the infiltration pattern in bone marrow trephine biopsy has been described before. The combined pattern analysis...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.016
更新日期:2006-09-01 00:00:00
abstract::In this review we summarize recent advances in the histopathological diagnostic criteria and molecular pathology of the main subtypes of ovarian surface epithelial carcinoma. These advances have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management. With pro...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2009.04.017
更新日期:2009-09-01 00:00:00
abstract::CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.029
更新日期:2017-06-01 00:00:00
abstract::A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90261-6
更新日期:1997-10-01 00:00:00
abstract::Although adipophilin has been reported to be a sensitive marker for sebaceous carcinoma, others have noted its expression in squamous cell carcinoma and a variety of noncutaneous tumors, suggesting that lipid droplet accumulation is a frequent feature of neoplastic cells. We investigated the expression of adipophilin ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.02.003
更新日期:2013-09-01 00:00:00
abstract::A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80247-2
更新日期:1987-07-01 00:00:00
abstract::Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90232-r
更新日期:1992-02-01 00:00:00
abstract::Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.017
更新日期:2013-10-01 00:00:00
abstract::Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.021
更新日期:2010-10-01 00:00:00
abstract::Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90200-o
更新日期:1990-04-01 00:00:00
abstract::Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90422-1
更新日期:1998-10-01 00:00:00
abstract::We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.030
更新日期:2017-01-01 00:00:00
abstract::The immunohistologic distribution of the basement membrane components, type IV collagen and laminin, was evaluated in 57 alcohol-fixed, paraffin-embedded tissue sections which demonstrated immunostaining patterns with antigen preservation similar to that of frozen tissue sections. Normal and hyperplastic squamous muco...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80221-6
更新日期:1987-10-01 00:00:00
abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.04.016
更新日期:2017-07-01 00:00:00
abstract::The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129416
更新日期:2002-11-01 00:00:00