Abstract：
:We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, the endometria of the danazol-treated patients were more atrophic than those of the women who received gestrinone. Some cell organelle involution was evident in patients of both treatment groups. After 6 months of treatment, marked endometrial atrophy was observed in all the patients, including those in whom spotting had occurred. The ultrastructural investigation demonstrated complete involution of the cytoplasmic organelles with cytoplasmic collapse in glandular cells of patients treated with danazol, whereas in the gestrinone group degeneration phenomena were observed in both nucleus and cytoplasm. Irregular secretory transformation was seen in the endometria of patients in both groups. Long-term treatment with danazol caused endometrial atrophy similar to that induced by gestrinone, but it appeared earlier; thus, the former drug seems preferable in short-term treatment.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Marchini M,Fedele L,Bianchi S,Di Nola G,Nava S,Vercellini Pdoi
10.1016/0046-8177(92)90011-qsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
51-6issue
1eissn
0046-8177issn
1532-8392pii
0046-8177(92)90011-Qjournal_volume
23pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2009.06.017
更新日期：2010-03-01 00:00:00
abstract：:Microsatellite instability (MSI) defines a specific type of genetic instability. Although consensus diagnostic criteria for MSI definition in colorectal cancer have been established, their utility in other tumor types remain to be proven. Previously we developed a mathematical model for MSI definition in colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.10.021
更新日期：2004-03-01 00:00:00
abstract：:The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90033-d
更新日期：1993-03-01 00:00:00
abstract：:Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80028-8
更新日期：1978-07-01 00:00:00
abstract：:It remains unclear why Barrett esophagus (BE)-associated adenocarcinoma (EAC) frequently occurs in the 0 to 3 o'clock area of the BE. The aims of this study were to clarify the localization of specialized intestinal metaplasia (SIM) as a precancerous lesion and of molecular alterations among different locations using ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.12.013
更新日期：2016-05-01 00:00:00
abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.08.010
更新日期：2019-11-01 00:00:00
abstract：:The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.05.025
更新日期：2011-02-01 00:00:00
abstract：:The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.01.010
更新日期：2011-11-01 00:00:00
abstract：:We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.30185
更新日期：2002-01-01 00:00:00
abstract：:The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80080-9
更新日期：1981-09-01 00:00:00
abstract：:Islets were evaluated for the presence of amyloid deposits in 169 pancreases removed at autopsy. Islet amyloid occurred in 17 of 142 (12 per cent) of nondiabetics and in 16 of 27 (59 per cent) of diabetics. When diabetics were divided into categories according to clinical severity of disease, the insulin treated diabe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80197-9
更新日期：1981-10-01 00:00:00
abstract：:The aims of this investigation were to compare quantitative with qualitative analysis of fluorescent in situ hybridization (FISH) centromere signals in interphase breast cancer cell nuclei and to evaluate the possible clinical utility of detecting numerical abnormalities of chromosomes 11 and 17 by FISH in the preoper...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90267-8
更新日期：1999-02-01 00:00:00
abstract：:Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.006
更新日期：2013-10-01 00:00:00
abstract：:AT-rich interactive domain 1A (ARID1A) is tumor suppressor gene that interacts with BRG1 adenosine triphosphatase to form a SWI/SNF chromatin remodeling protein complex. Inactivation of ARID1A has been described in several neoplasms, including epithelial ovarian and endometrial carcinomas, and has been correlated with...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：:Multifocal/multicentric breast cancers are common. However, investigations of biomarkers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in individual tumor foci of such cancers are rare. This study was designed to evaluate the status of the hormone receptors, human epide...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.08.026
更新日期：2012-01-01 00:00:00
abstract：:Although the therapeutic outcome of osteosarcoma patients has improved dramatically within the last 20 years because of combined neoadjuvant chemotherapy and surgery, the problem of drug resistance remains. Thus far, markers that can predict the response to chemotherapy at the time of biopsy are not available. Heat sh...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90412-9
更新日期：1998-10-01 00:00:00
abstract：:Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.11.008
更新日期：2018-02-01 00:00:00
abstract：:Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90161-h
更新日期：1991-03-01 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.07.018
更新日期：2018-12-01 00:00:00
abstract：:Decreases in true expenses in the hospital clinical laboratory consequent to reduced utilization were estimated from four models. Each category of direct expense was adjusted according to projections and confirmed to the extent possible by actual experience. No projections of reductions in indirect expenses were made....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80002-7
更新日期：1984-06-01 00:00:00
abstract：:We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.021
更新日期：2011-09-01 00:00:00
abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80170-0
更新日期：1981-08-01 00:00:00
abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.01.003
更新日期：2018-04-01 00:00:00
abstract：:A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80178-5
更新日期：1981-08-01 00:00:00
abstract：:In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.008
更新日期：2008-08-01 00:00:00
abstract：:The use of prosthetic implants for breast augmentation has become commonplace. Although implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report 2 cases of breast implant capsule-associated squamous cell carcinoma with poor clinical ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.07.011
更新日期：2017-09-01 00:00:00
abstract：:Combined small cell and non-small cell carcinoma is relatively rare in the lung. Examination of the clonal relationship of different components in this type of tumor may give a clue to the rarity. We retrieved 6 such tumors; all 6 had small cell carcinoma and adenocarcinoma components, and 3 had an additional squamous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/j.humpath.2003.05.001
更新日期：2003-11-01 00:00:00
abstract：:Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.025
更新日期：2012-08-01 00:00:00
abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90432-4
更新日期：1998-10-01 00:00:00
abstract：:Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal ant...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80235-1
更新日期：1988-12-01 00:00:00
