Abstract：
:Two undifferentiated (embryonal) sarcomas of liver were studied ultrastructurally and immunohistochemically. Electron microscopic examination of the pleomorphic tumor cells revealed fibroblastic and histiocytic characteristics. There were no specific findings to support rhabdomyoblastic, leiomyoblastic, or epithelial differentiation. Cytoplasmic peroxidase-antiperoxidase (PAP) immunohistochemical staining for vimentin, alpha1-antitrypsin, and alpha1-antichymotrypsin was found. No staining for epidermal or internal organ cytokeratins, desmin, myoglobin, or alpha-fetoprotein was observed. The ultrastructural correlates of the cytoplasmic periodic acid-Schiff-positive, diastase-resistant hyaline globules were large, membrane-bound, heterogenous electron-dense inclusions, probably lysosomal in origin. These inclusions did not react on either alpha1-antitrypsin or alpha1-antichymotrypsin PAP staining. Tumor specimens from two metastatic sites were also examined. Neither contained the ducts or cysts that characterized the primary tumor. These studies confirm the mesenchymal nature of this uncommon childhood neoplasm and support the suggestion that the cytoplasmic hyaline globules represent a degenerative phenomenon. There are ultrastructural and immunohistochemical similarities with malignant fibrous histiocytoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Keating S,Taylor GPdoi
10.1016/s0046-8177(85)80154-4subject
Has Abstractpub_date
1985-07-01 00:00:00pages
693-9issue
7eissn
0046-8177issn
1532-8392pii
S0046-8177(85)80154-4journal_volume
16pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2011.07.020
更新日期：2012-04-01 00:00:00
abstract：:The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90238-x
更新日期：1992-02-01 00:00:00
abstract：:A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90199-x
更新日期：1998-09-01 00:00:00
abstract：:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.08.003
更新日期：2020-10-01 00:00:00
abstract：:Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.05.026
更新日期：2015-10-01 00:00:00
abstract：:The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark. G9a is over-expressed in tumor cells and contributes to cancer aggressiveness. Biliary tract cancer (BTC) is a rare cancer with dismal prognosis due to a lack of effective ther...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.11.003
更新日期：2018-02-01 00:00:00
abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.12.012
更新日期：2018-03-01 00:00:00
abstract：:We studied renal tissues from 203 patients with acquired immunodeficiency syndrome (AIDS). Of the 203 patients, 20 showed light-microscopic changes characteristic of AIDS-associated nephropathy (AAN). Fifteen of the 20 (group A) were examined by immunohistochemistry using Mycoplasma fermentans (incognitus strain)-spec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90063-u
更新日期：1991-01-01 00:00:00
abstract：:Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.06.002
更新日期：2007-01-01 00:00:00
abstract：:There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.09.001
更新日期：2005-11-01 00:00:00
abstract：:Semaphorins (SEMAs) compete with vascular endothelial growth factor (VEGF) for receptor neuropilin 1 (NP1) and 2 (NP2) and suppress angiogenesis. To clarify the involvement of SEMA and VEGF in the development and progression of ovarian carcinoma, we analyzed the immunohistochemical expression of SEMA, VEGF, NP1, and N...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.031
更新日期：2006-11-01 00:00:00
abstract：:Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.03.008
更新日期：2014-08-01 00:00:00
abstract：:Immunohistochemical localization of transforming growth factor beta 1 (TGF-beta 1) was studied in Kaposi's sarcoma (KS) tissues obtained from autopsy and biopsy materials of patients with and without acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) infection. There was no difference in t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90241-4
更新日期：1995-05-01 00:00:00
abstract：:Anaplastic meningiomas (MIIIs) and meningeal hemangiopericytomas (HPCs) display significant morphologic and immunohistochemical overlap, including occasional cases of otherwise classic HPC with focal epithelial membrane antigen (EMA) positivity. The availability of several new biomarkers prompted us to examine the pot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.017
更新日期：2004-11-01 00:00:00
abstract：:We report three cases of follicular dendritic cell sarcoma (FDCS) showing a hitherto undescribed histological pattern consisting of nodular tumor growth associated with small B lymphocytes. FDCS tumor cells consistently showed large epithelioid features and were intermingled with small lymphocytes in the nodules in tw...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.02.029
更新日期：2012-02-01 00:00:00
abstract：:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta ce...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80154-0
更新日期：1988-10-01 00:00:00
abstract：:Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.013
更新日期：2014-08-01 00:00:00
abstract：:Pseudomonas pneumonia is an uncommon but serious infection in infants, occurring mainly in infants of low birth weight. In this retrospective clinicopathologic correlation study, we reviewed the clinical records and analyzed postmortem lung pathology in 8 infants with pneumonia due to P. aeruginosa. From the histopath...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00353-8
更新日期：2003-09-01 00:00:00
abstract：:It remains unclear why Barrett esophagus (BE)-associated adenocarcinoma (EAC) frequently occurs in the 0 to 3 o'clock area of the BE. The aims of this study were to clarify the localization of specialized intestinal metaplasia (SIM) as a precancerous lesion and of molecular alterations among different locations using ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.12.013
更新日期：2016-05-01 00:00:00
abstract：:Seminoma and sarcoidosis do not seem to be associated diseases, judging from epidemiologic data. The presence of these two diseases in the patient whose case is reported may have been coincidental. It was observed, however, that when the testis tumor appeared in this patient, the longstanding sarcoid lesions significa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80041-6
更新日期：1984-04-01 00:00:00
abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.002
更新日期：2009-11-01 00:00:00
abstract：:Alterations of the epidermal growth factor receptor (EGFR) can be observed in a significant subset of esophageal adenocarcinomas (EACs), and targeted therapy against EGFR may become an interesting approach for the treatment of these tumors. Mutations of KRAS, NRAS, BRAF, and phosphatidylinositol-3-kinase catalytic sub...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.08.005
更新日期：2013-05-01 00:00:00
abstract：:Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125381
更新日期：2002-08-01 00:00:00
abstract：:Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.08.004
更新日期：2015-12-01 00:00:00
abstract：:This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90304-4
更新日期：1996-11-01 00:00:00
abstract：:The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(96)90362-7
更新日期：1996-02-01 00:00:00
abstract：:Angiocentric immunoproliferative lesions (AILs) are believed to represent a unique type of extranodal malignant lymphoma on the basis of clinicopathologic and immunophenotypic evidence. However, molecular studies to assess clonality have been performed on a small number of cases. In this study we assessed the clonalit...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90269-u
更新日期：1991-11-01 00:00:00
abstract：:In a prior study we reported that monotypic immunoglobulin expression significantly correlated with an increased risk of dissemination by small lymphocytic infiltrates (SLIs) of the orbit and conjunctiva. However, less than half of all monotypic SLIs disseminated. In this study, we applied a large panel of monoclonal ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90149-y
更新日期：1990-11-01 00:00:00
abstract：:Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80046-9
更新日期：1981-07-01 00:00:00
abstract：:Organ transplant recipients have an increased tumor incidence owing to their immunocompromised state. The origin of such tumors, whether donor or recipient, will have a clinical impact on decision-making concerning immunosuppressive therapy, retransplantation, and for recipients of other organs from the same donors. W...
journal_title：Human pathology
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
