Abstract：
:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45; gain, 15 of 45 and loss/imbalance, 11 of 45) in a total of 27 (60%) of 45 neuroblastomas. Synchronic MYCN and ALK aberrations accounted for 23 of 45 (51%) tumors; however, MYCN alterations were also detected in 11 (60%) of 18 tumors without ALK aberrations. Our data suggest that copy number aberrations of the ALK gene is a frequent genetic event in the development of neuroblastomas. In addition, no correlation was observed between ALK aberrations and alterations of 11q, 17q, and 1p36.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Subramaniam MM,Piqueras M,Navarro S,Noguera Rdoi
10.1016/j.humpath.2009.05.002subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1638-42issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(09)00162-2journal_volume
40pub_type
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