Abstract:
:The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; range, 3 to 96 years), with men outnumbering women slightly by a ratio of 4 to 3. The most frequent presenting complaints are headache, weakness, and confusion; less common complaints are aphasia, dysphasia, nausea or vomiting, loss of memory, and seizure disorder. There is usually no evidence of a systemic disease; the erythrocyte sedimentation rate is almost invariably normal, and there are no diagnostic laboratory tests. The cerebral angiogram usually shows multifocal, segmental stenosis or irregularity of small and medium-sized leptomeningeal and intracranial blood vessels, often with a beading or aneurysmal appearance, and alterations in blood flow in the affected regions. Anatomically, the angiitis is focal and segmental in distribution. An isolated negative biopsy, therefore, does not rule out the disease. Histologically, PACNS may be granulomatous, necrotizing, or lymphocytic in character, and mixed morphologic types often occur. Large- and small-vessel thrombosis is common. Acute lesions frequently coexist with healing or healed lesions. Involvement of extracranial blood vessels occurs only rarely. Past or current herpes zoster infection and Hodgkin's lymphoma are the most noteworthy clinical associations of PACNS, but whether they are causally related remains uncertain.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Lie JTdoi
10.1016/0046-8177(92)90238-xsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
164-71issue
2eissn
0046-8177issn
1532-8392pii
0046-8177(92)90238-Xjournal_volume
23pub_type
杂志文章,评审相关文献
HUMAN PATHOLOGY文献大全abstract::Lymphoplasmacytic infiltrates in the breast, a modified skin appendage, include lymphocytic lobulitis, other nonspecific benign proliferations, and mucosa-associated lymphoid tissue (MALT)-type lymphoma. Distinguishing these entities, all of which may be B-cell rich and may have associated sclerosis, can be difficult....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.04.006
更新日期:2015-08-01 00:00:00
abstract::Insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3) is an oncofetal protein that promotes tumor progression and metastasis in a number of malignancies. However, the clinical significance of IMP3 expression in squamous cell carcinoma (SCC) of the uterine cervix is unclear. In this study, the cor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.07.006
更新日期:2014-11-01 00:00:00
abstract::The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.022
更新日期:2007-09-01 00:00:00
abstract::Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90096-l
更新日期:1992-04-01 00:00:00
abstract::The family of the poly(adenosine diphosphate-ribose) polymerase (PARP) proteins is directly involved in genomic stability, DNA repair, and apoptosis by DNA damage. In this study, we evaluated the role of PARP-1 in melanoma and its prognostic importance. We studied by immunohistochemistry and Western blot analysis PARP...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.04.017
更新日期:2005-07-01 00:00:00
abstract::Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hp.2000.6699
更新日期:2000-05-01 00:00:00
abstract::Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90231-3
更新日期:1998-02-01 00:00:00
abstract::Alterations in the Notch signaling pathway play a role in colorectal cancer (CRC). Hes1, a Notch-induced transcription factor, has recently been reported to show decreased expression by immunohistochemistry in sessile serrated adenomas. Variable staining patterns have been reported in tubular adenomas, and existing da...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.010
更新日期:2016-11-01 00:00:00
abstract::Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal ant...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80235-1
更新日期:1988-12-01 00:00:00
abstract::We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90065-5
更新日期:1994-10-01 00:00:00
abstract::The aims of this investigation were to compare quantitative with qualitative analysis of fluorescent in situ hybridization (FISH) centromere signals in interphase breast cancer cell nuclei and to evaluate the possible clinical utility of detecting numerical abnormalities of chromosomes 11 and 17 by FISH in the preoper...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90267-8
更新日期:1999-02-01 00:00:00
abstract::Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models. Snail1 and ZEB1 are frequently coexpressed in tumor cell lines, suggesting that these factors may cooperate to promote tumor progression. However, coexpression of these transcriptional repressors in primary huma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.004
更新日期:2011-08-01 00:00:00
abstract::Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.10.017
更新日期:2019-03-01 00:00:00
abstract::To elucidate the role of Epstein-Barr virus (EBV) in salivary gland carcinomas, 56 cases of carcinomas of major salivary glands were investigated. These included 14 mucoepidermoid carcinomas, 13 adenoid cystic carcinomas, seven malignant mixed tumors, four adenocarcinomas, four salivary duct carcinomas, two acinic cel...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90066-0
更新日期:1996-03-01 00:00:00
abstract::Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjace...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90249-6
更新日期:1994-08-01 00:00:00
abstract::Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80017-4
更新日期:1985-03-01 00:00:00
abstract::Plasmacytoid dendritic cells, which play a fundamental role in the innate immune response, are best known for their presence in hyaline-vascular Castleman disease and histiocytic necrotizing lymphadenitis. The relative number and distribution in many reactive entities as detected using more sensitive methods are uncer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.08.020
更新日期:2013-06-01 00:00:00
abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90039-3
更新日期:1997-04-01 00:00:00
abstract::The histopathology of 72 paragangliomas originating in the head and neck region of 71 patients is presented. There were 45 carotid body, 13 vagal body, eight jugulotympanic, and three nasal paragangliomas. In addition, two arose in the larynx and one in the area of the aortic arch. Tumors occurred in four unrelated fa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(79)80008-8
更新日期:1979-03-01 00:00:00
abstract::A unique case of primary papillary hyperplasia of the gallbladder and cystic and common bile ducts occurring in a young female without calculi, ulcerative colitis, or primary sclerosing cholangitis is reported. The papillary lesion involved the mucosa of the entire gallbladder and of the cystic and common bile ducts. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90134-q
更新日期:1990-02-01 00:00:00
abstract::A case of clear cell sarcoma of tendons and aponeuroses arising in the elbow of a young woman is reported. Local recurrence and lymph node metastases occurred despite radiation therapy, chemotherapy, and amputation of the right arm, and the patient died of the tumor approximately ten months after the initial diagnosis...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80267-6
更新日期:1983-12-01 00:00:00
abstract::The introduction of chemotherapeutic agents directly into the proper hepatic artery via an indwelling catheter results in perfusion of the gallbladder, because the cystic artery is usually a branch of the right hepatic artery. Five gallbladders, removed two to 16 months after insertion of permanently implanted Infusai...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80275-6
更新日期:1985-10-01 00:00:00
abstract::Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.010
更新日期:2018-12-01 00:00:00
abstract::A 33-year-old male runner, who had undergone a Swanson silastic prosthetic implant for degenerative joint disease of the first metatarsal head and proximal phalanx of the right great toe, presented with unilateral inguinal lymphadenopathy. Biopsy revealed confluent, non-caseating granulomas containing silastic materia...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80158-8
更新日期:1988-10-01 00:00:00
abstract::Thromboangiitis obliterans (Buerger's disease) is an uncommon variety of occlusive peripheral vascular disease, occurring predominantly in young male tobacco smokers. The vascular lesion in the acute stage of thromboangiitis obliterans is distinctive and affects both the arteries and veins. Described here is an unusua...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80174-0
更新日期:1987-04-01 00:00:00
abstract::CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.29678
更新日期:2001-12-01 00:00:00
abstract::Fifty-three surgically resected small cell carcinomas of the lung were studied morphometrically, electron microscopically, immunohistochemically, and in terms of possible site of origin. Four subtypes of small cell carcinomas were identified: oat cell carcinoma (OAT), small cell carcinoma of the intermediate cell type...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80133-2
更新日期:1986-06-01 00:00:00
abstract::Several matrix metalloproteinases (MMPs) are implicated in the degradation of the epithelial basement membrane (BM), invasiveness, and malignancy of endometrial and ovarian carcinomas. We have recently proposed a cooperative role for RUNX1/AML1 and ETV5/ERM in myometrial infiltration during endometrioid endometrial in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.01.025
更新日期:2011-01-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.026
更新日期:2015-10-01 00:00:00
abstract::This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90304-4
更新日期:1996-11-01 00:00:00