Abstract：
:Insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3) is an oncofetal protein that promotes tumor progression and metastasis in a number of malignancies. However, the clinical significance of IMP3 expression in squamous cell carcinoma (SCC) of the uterine cervix is unclear. In this study, the correlation between IMP3 expression and cervical cancer progression and prognosis was assessed by immunohistochemistry. IMP3 expression was observed in a large number of tissue specimens from patients with normal cervical tissues, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, and SCC. IMP3 protein and mRNA expression was also determined in the SiHa and HeLa human cervical cancer cell lines. IMP3 expression was observed in 0 (0%) of 62 CIN I, 0 (0%) of 38 CIN II, and 9 (8.7%) of 104 CIN III specimens. Of the 96 SCC cases, IMP3 expression was detected in 54 cases (56.3%). Significant difference in IMP3 expression existed between all of the groups tested (P < .001). IMP3 protein and mRNA expressions in SiHa and HeLa cell lines were dramatically increased, as compared with normal tissue (P < .001). IMP3 expression was significantly related to age (P < .001), International Federation of Gynecology and Obstetrics stage (P < .001), and lymph node metastasis (P = .001). IMP3 expression was also shown to be an independent prognostic factor in SCC. In conclusion, these findings suggest that IMP3 expression may be a prognostic indicator of SCC.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Wei Q,Yan J,Fu B,Liu J,Zhong L,Yang Q,Zhao Tdoi
10.1016/j.humpath.2014.07.006subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2218-24issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00288-3journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Malignant mesotheliomas are highly aggressive tumors that develop most frequently in the pleura of patients chronically exposed to asbestos. The distinction between malignant mesotheliomas and tumors of epithelial origin, particularly peripheral lung adenocarcinoma, can be difficult despite the use of immunocytochemic...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90302-x
更新日期：1995-12-01 00:00:00
abstract：:Twenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90056-m
更新日期：1993-01-01 00:00:00
abstract：:Primary dermal melanoma (PDM) is a rare variant of melanoma which simulates metastatic melanoma to the skin. Diagnosis of PDM cannot be established on histologic grounds alone but requires absence of evidence of melanoma elsewhere by clinical history and/or imaging studies. Despite this entity being clinically well do...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.002
更新日期：2020-12-01 00:00:00
abstract：:We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.010
更新日期：2015-04-01 00:00:00
abstract：:Cytoplasmic mislocalization of p27 (CDKN1B/KIP1) is caused by activated AKT1 and has been associated with poor prognosis in various cancers. CIMP in colorectal cancer is characterized by extensive promoter methylation and is associated with MSI-MSI-H and BRAF mutations. We have recently shown a positive correlation be...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.09.014
更新日期：2007-04-01 00:00:00
abstract：:In this review we summarize recent advances in the histopathological diagnostic criteria and molecular pathology of the main subtypes of ovarian surface epithelial carcinoma. These advances have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management. With pro...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2009.04.017
更新日期：2009-09-01 00:00:00
abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80164-6
更新日期：1983-10-01 00:00:00
abstract：:GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.05.022
更新日期：2013-11-01 00:00:00
abstract：:Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.07.010
更新日期：2018-12-01 00:00:00
abstract：:Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90072-7
更新日期：1998-05-01 00:00:00
abstract：:The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicula...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.01.035
更新日期：2012-01-01 00:00:00
abstract：:A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90064-a
更新日期：1992-12-01 00:00:00
abstract：:We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90292-o
更新日期：1993-02-01 00:00:00
abstract：:Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonsemin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.09.007
更新日期：2019-02-01 00:00:00
abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.006
更新日期：2004-01-01 00:00:00
abstract：:An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.12.020
更新日期：2012-10-01 00:00:00
abstract：:The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.033
更新日期：2018-12-01 00:00:00
abstract：:The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90125-1
更新日期：1989-03-01 00:00:00
abstract：:The reticulin stain is a critical diagnostic aide used to differentiate benign hepatocellular proliferations from well differentiated hepatocellular carcinoma (HCC). Rarely, however, hepatocellular carcinomas do not show definitive loss of reticulin in liver biopsy specimens. To study this group of tumors, 11 HCC with...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.015
更新日期：2021-01-01 00:00:00
abstract：:Morphological discrimination of urothelial carcinoma (UC) in situ, a precursor of high-grade invasive carcinoma, from severe reactive atypia is essential, but can be challenging at times. Mutations of the cell cycle regulatory gene INK4a (located at 9p21) that encodes p16(INK4) are one of the critical early events in ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.005
更新日期：2008-04-01 00:00:00
abstract：:Two patients with systemic capillary leak syndrome (SCLS) were followed up clinically for 5 and 2 years, respectively. Muscle biopsy was performed 1 week after the end of an acute crisis in one patient, and after 3 years in the other. In both cases, muscle capillary basement membranes were extremely thick--more than 1...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90230-3
更新日期：1990-03-01 00:00:00
abstract：:Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.003
更新日期：2010-06-01 00:00:00
abstract：:Ovarian surface epithelial carcinomas are routinely subclassified by pathologists based on tumor cell type and grade. It is controversial whether cell type or grade is superior in predicting patient response to treatment or survival, in patients stratified by stage of disease. The aim of this study was to uniformly ap...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.01.003
更新日期：2008-08-01 00:00:00
abstract：:Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90170-8
更新日期：1994-01-01 00:00:00
abstract：:Differentiation features and proliferation activity of 67 gastric microleiomyomas (microLMs) and 53 clinical gastrointestinal stromal tumors (GISTs) of the stomach were compared. The 67 microLMs were divided into two categories on the basis of cellularity: 53 hypocellular and 14 hypercellular types, and the 39 GISTs w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90223-9
更新日期：1997-12-01 00:00:00
abstract：:Esophageal adenocarcinoma often presents at an advanced stage and has a dismal prognosis. Current prognostic markers have limited utility. ARID1A is implicated as a tumor suppressor gene in esophageal adenocarcinoma. Loss of ARID1A expression correlates with DNA mismatch repair (MMR) protein deficiency in other tumors...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.09.004
更新日期：2019-12-01 00:00:00
abstract：:Metastatic cystic squamous cell carcinomas of the neck often harbor human papillomavirus 16 and, in turn, overexpress p16. P16 immunohistochemistry could be useful in the evaluation of patients who present with cystic squamous lesions of the neck, particularly when the distinction between a benign lymphoepithelial cys...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.09.006
更新日期：2010-04-01 00:00:00
abstract：:This article reviews 281 malignant germ cell tumors of the ovary from the Armed Forces Institute of Pathology and highlights their distinctive clinical and pathologic features. Emphasis is placed on the importance of a combined therapeutic approach utilizing surgery, chemotherapy, and radiation. The rationale for unil...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(77)80115-9
更新日期：1977-09-01 00:00:00
abstract：:Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80287-9
更新日期：1988-11-01 00:00:00
abstract：:An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80057-9
更新日期：1982-10-01 00:00:00
