Applications of electron microscopy to diagnostic pulmonary pathology.

abstract：:The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...

journal_title：Human pathology

authors： Bonkhoff H,Stein U,Remberger K

更新日期：1993-03-01 00:00:00

abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...

journal_title：Human pathology

authors： Wang H,Kohashi K,Yoshizumi T,Okumura Y,Tanaka Y,Shimokawa M,Iwasaki T,Aishima S,Maehara Y,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...

journal_title：Human pathology

authors： Klieser E,Urbas R,Stättner S,Primavesi F,Jäger T,Dinnewitzer A,Mayr C,Kiesslich T,Holzmann K,Di Fazio P,Neureiter D,Swierczynski S

更新日期：2017-07-01 00:00:00

abstract：:Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...

journal_title：Human pathology

authors： Hu M,Li K,Maskey N,Xu Z,Yu F,Peng C,Li Y,Yang G

更新日期：2015-12-01 00:00:00

abstract：:Malignant mesotheliomas are highly aggressive tumors that develop most frequently in the pleura of patients chronically exposed to asbestos. The distinction between malignant mesotheliomas and tumors of epithelial origin, particularly peripheral lung adenocarcinoma, can be difficult despite the use of immunocytochemic...

journal_title：Human pathology

authors： Peralta Soler A,Knudsen KA,Jaurand MC,Johnson KR,Wheelock MJ,Klein-Szanto AJ,Salazar H

更新日期：1995-12-01 00:00:00

abstract：:Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...

journal_title：Human pathology

authors： Olivera P,Perez E,Ortega A,Terual R,Gomes C,Moreno LF,Dueñas A,De La Garza J,Melendez-Zajgla J,Maldonado V

更新日期：2002-02-01 00:00:00

abstract：:Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other typ...

journal_title：Human pathology

authors： Abenoza P,Sibley RK

更新日期：1986-07-01 00:00:00

abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...

journal_title：Human pathology

authors： Carney JA,Lyssikatos C,Lodish MB,Stratakis CA

更新日期：2015-01-01 00:00:00

abstract：:Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...

journal_title：Human pathology

authors： de Freitas RS,Dantas KC,Garcia RS,Magri MM,de Andrade HF Jr

更新日期：2010-09-01 00:00:00

abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...

journal_title：Human pathology

authors： Yang XJ,Tretiakova MS,Sengupta E,Gong C,Jiang Z

更新日期：2003-05-01 00:00:00

abstract：:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...

journal_title：Human pathology

authors： Lorenzato M,Caudroy S,Bronner C,Evrard G,Simon M,Durlach A,Birembaut P,Clavel C

更新日期：2005-10-01 00:00:00

abstract：:Insulin-like growth factor-II messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is a biomarker whose expression has been found to be a negative prognostic factor in several neoplasms including ovarian clear cell carcinoma (CCC). In this study, we analyzed the frequency and clinicopathologic significance of IMP3 expres...

journal_title：Human pathology

authors： Fadare O,Liang SX,Crispens MA,Jones HW 3rd,Khabele D,Gwin K,Zheng W,Mohammed K,Parkash V,Hecht JL,Desouki MM

更新日期：2013-08-01 00:00:00

abstract：:The introduction of chemotherapeutic agents directly into the proper hepatic artery via an indwelling catheter results in perfusion of the gallbladder, because the cystic artery is usually a branch of the right hepatic artery. Five gallbladders, removed two to 16 months after insertion of permanently implanted Infusai...

journal_title：Human pathology

authors： Marymont JV,Dakhil SR,Travers H,Housholder DF

更新日期：1985-10-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas an...

journal_title：Human pathology

authors： Chong EY,Lam PY,Poon WS,Ng HK

更新日期：1998-06-01 00:00:00

abstract：:It has been suggested that atypical adenomatous hyperplasia (AAH) may be a precursor of peripheral adenocarcinoma of the lung. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA onto chromosomal ends. Its activity is believed to be crucial for cellular immortality, and it is thought to participate...

journal_title：Human pathology

authors： Nakanishi K,Kawai T,Kumaki F,Hirot S,Mukai M,Ikeda E

更新日期：2002-07-01 00:00:00

abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...

journal_title：Human pathology

authors： Hervieu V,Christa L,Gouysse G,Bouvier R,Chayvialle JA,Bréchot C,Scoazec JY

更新日期：2006-08-01 00:00:00

abstract：:Loss or reduced expression of E-cadherin has been shown to be associated with poor survival in patients with bladder cancer. In numerous cases, loss of E-cadherin expression in bladder tumors has been accompanied by continued association of catenins with the membrane, suggestive of the expression of an alternative cad...

journal_title：Human pathology

authors： Rieger-Christ KM,Cain JW,Braasch JW,Dugan JM,Silverman ML,Bouyounes B,Libertino JA,Summerhayes IC

更新日期：2001-01-01 00:00:00

abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...

journal_title：Human pathology

authors： Uchida K,Ross H,Lotan T,Pignon JC,Signoretti S,Epstein JI,Illei PB

更新日期：2015-03-01 00:00:00

abstract：:To elucidate the role of Epstein-Barr virus (EBV) in salivary gland carcinomas, 56 cases of carcinomas of major salivary glands were investigated. These included 14 mucoepidermoid carcinomas, 13 adenoid cystic carcinomas, seven malignant mixed tumors, four adenocarcinomas, four salivary duct carcinomas, two acinic cel...

journal_title：Human pathology

authors： Tsai CC,Chen CL,Hsu HC

更新日期：1996-03-01 00:00:00

abstract：:Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...

journal_title：Human pathology

authors： Tan J,Sidhu G,Greco MA,Ballard H,Wieczorek R

更新日期：1998-04-01 00:00:00

abstract：:Hypertrophic cardiomyopathy phenotype is shared by heterogeneous entities. The purpose of the study was to evaluate the diagnostic role of left ventricular endomyocardial biopsy. One hundred fifty-one consecutive patients with unexplained left ventricular hypertrophy and normal/elevated QRS voltages or left bundle-bra...

journal_title：Human pathology

authors： Frustaci A,Russo MA,Chimenti C

更新日期：2013-01-01 00:00:00

abstract：:Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited. This study was carried out to evaluate the frequency of BRAF V600E ...

journal_title：Human pathology

authors： Chatterjee D,Garg C,Singla N,Radotra BD

更新日期：2018-10-01 00:00:00

abstract：:Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and a known mediator of glucocorticoid-regulated inflammatory responses. Using a combined multiple high-throughput approach, we recently identified a reduced expression of ANXA1 in human breast cancer. The finding was confirmed at the gene level by quan...

journal_title：Human pathology

authors： Shen D,Nooraie F,Elshimali Y,Lonsberry V,He J,Bose S,Chia D,Seligson D,Chang HR,Goodglick L

更新日期：2006-12-01 00:00:00

abstract：:In order to study the granular transformation of Sertoli cells the following testicular specimens were reviewed: 58 postmortem biopsies from 21 children and 37 young adult males with normal histologic pattern; 165 biopsies from prepubertal cryptorchid testes; 38 biopsies and 18 surgical specimens from postpubertal-cry...

journal_title：Human pathology

authors： Nistal M,Garcia-Rodeja E,Paniagua R

更新日期：1991-02-01 00:00:00

abstract：:Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...

journal_title：Human pathology

authors： Kataria YP,Zafranas A,Sharma HM

更新日期：1978-09-01 00:00:00

abstract：:Immunofluorescence of formalin-fixed, paraffin-embedded tissues was performed to study the plasma cell population in 114 colonic specimens from 58 patients. Correlation of the histopathologic stage of disease activity with the isotypes and numbers of immunoglobulin-containing cells in the lamina propria demonstrated h...

journal_title：Human pathology

authors： Keren DF,Appelman HD,Dobbins WO 3rd,Wells JJ,Whisenant B,Foley J,Dieterle R,Geisinger K

更新日期：1984-08-01 00:00:00

abstract：:In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not...

journal_title：Human pathology

authors： Ulbright TM,Clark SA,Einhorn LH

更新日期：1985-03-01 00:00:00

abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

journal_title：Human pathology

authors： Michel RP,Limacher JJ,Kimoff RJ

更新日期：1982-01-01 00:00:00

abstract：:Twelve cases of bizarre parosteal osteochondromatous proliferation (BPOP), also known as Nora's lesion, are reported. Ten lesions were located in the small bones of the hands, and 2 were located in long bones (femur and proximal tibia). Patient age ranged from 12 to 63 years (average, 30.3 years). Radiography of the l...

journal_title：Human pathology

authors： Abramovici L,Steiner GC

更新日期：2002-12-01 00:00:00

abstract：:Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. The aim of this study was to investigate expression of Yes-associated protein in lung adenocarcinoma and squamous cell carcinoma. Associations of Yes-associated protein express...

journal_title：Human pathology

authors： Kim JM,Kang DW,Long LZ,Huang SM,Yeo MK,Yi ES,Kim KH

更新日期：2011-03-01 00:00:00