Telomerase expression in gliomas including the nonastrocytic tumors.


:Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas and low-grade astrocytic gliomas have been examined before, telomerase activity from a broad spectrum of astrocytic and nonastrocytic gliomas were examined in this study. A total of 119 brain tumor samples, including 16 pilocytic astrocytomas, one dysembryoplastic neuroepithelial tumor (DNT), two pleomorphic xanthoastrocytomas (PXA), 15 ependymomas, 21 oligodendrogliomas, 13 grade II astrocytomas, 13 anaplastic astrocytomas, and 38 glioblastoma multiforme tumors (GBM), were studied, using a polymerase chain reaction (PCR)-based telomeric repeat amplification protocol assay. All pilocytic astrocytomas, DNT, PXA, and myxopapillary ependymomas were telomerase negative. Three of 13 (15.4%) classical ependymomas, 2 of 14 (14.3%) grade II oligodendrogliomas, and three of seven (42.9%) anaplastic oligodendrogliomas had detectable telomerase activity. The frequency of telomerase expression in ependymomas and oligodendrogliomas was lower than those observed in astrocytic tumors: fibrillary astrocytoma, 23.1%; anaplastic astrocytoma, 23.1%; and GBM, 26.3%. The mean age of telomerase-positive GBM patients (61.7 years) was significantly higher than that of telomerase-negative GBM patients (47.8 years, P=.002). These results suggest that telomerase activation may occur early in glial tumorigenesis, and astrocytomas may have mechanisms of immortalization other than telomerase activation.


Hum Pathol


Human pathology


Chong EY,Lam PY,Poon WS,Ng HK




Has Abstract


1998-06-01 00:00:00














  • Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34betaE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung.

    abstract::Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung aden...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Sturm N,Lantuéjoul S,Laverrière MH,Papotti M,Brichon PY,Brambilla C,Brambilla E

    更新日期:2001-09-01 00:00:00

  • Destruction of canals of Hering in primary biliary cirrhosis.

    abstract::The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Saxena R,Hytiroglou P,Thung SN,Theise ND

    更新日期:2002-10-01 00:00:00

  • Unusual aspects of allergic bronchopulmonary fungal disease: report of two cases due to Curvularia organisms associated with allergic fungal sinusitis.

    abstract::We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Travis WD,Kwon-Chung KJ,Kleiner DE,Geber A,Lawson W,Pass HI,Henderson D

    更新日期:1991-12-01 00:00:00

  • Marginal zone B-cell lymphomas: an appraisal.

    abstract::Although the Revised European-American Lymphoma Classification does not utilize the term monocytoid B-cell Lymphoma, there are numerous reasons to support its use in classifying lymphomas of so-called marginal zone B-cell type that contain a distinct population of malignant monocytoid B-cells. In addition, there are o...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Nathwani BN,Hernandez AM,Deol I,Taylor CR

    更新日期:1997-01-01 00:00:00

  • Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence.

    abstract::Aquaporin 5 (AQP5) is an androgen-regulated member of a family of small hydrophobic integral transmembrane water channel proteins regulating cellular water homeostasis and growth signaling. To evaluate its clinical impact and relationship with key genomic alterations in prostate cancer, AQP5 expression was analyzed by...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Pust A,Kylies D,Hube-Magg C,Kluth M,Minner S,Koop C,Grob T,Graefen M,Salomon G,Tsourlakis MC,Izbicki J,Wittmer C,Huland H,Simon R,Wilczak W,Sauter G,Steurer S,Krech T,Schlomm T,Melling N

    更新日期:2016-02-01 00:00:00

  • A comparative assessment of proliferating cell nuclear antigen, c-myc p62, and nucleolar organizer region staining in non-Hodgkin's lymphomas: a histochemical and immunohistochemical study of 200 cases.

    abstract::Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Korkolopoulou P,Patsouris E,Pangalis G,Tsenga A,Elemenoglou J,Thomas-Tsangli E,Spandidos D,Kittas C

    更新日期:1993-04-01 00:00:00

  • Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy.

    abstract::The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nishimura S,Tsuda H,Kataoka F,Arao T,Nomura H,Chiyoda T,Susumu N,Nishio K,Aoki D

    更新日期:2011-04-01 00:00:00

  • p53 alterations in atypical alveolar hyperplasia of the human lung.

    abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Slebos RJ,Baas IO,Clement MJ,Offerhaus GJ,Askin FB,Hruban RH,Westra WH

    更新日期:1998-08-01 00:00:00

  • High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.

    abstract::Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Chu S,Wen Q,Qing Z,Luo J,Wang W,Chen L,Feng J,Xu L,Zang H,Fan S

    更新日期:2017-03-01 00:00:00

  • Assessment and diagnostic utility of the cytotoxic T-lymphocyte phenotype using the specific markers granzyme-B and TIA-1 in esophageal mucosal biopsies.

    abstract::Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

    更新日期:1999-04-01 00:00:00

  • Isolated xanthomatosis of the small bowel.

    abstract::A case of xanthomatosis of the small bowel is described. Beginning with the proximal jejunum, an 85-cm segment of small bowel was distorted by regularly spaced nodular accumulations of lipid-laden macrophages that expanded the submucosa and muscularis and extended to the serosal surface. The conditions often associate...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Coletta U,Sturgill BC

    更新日期:1985-04-01 00:00:00

  • Targeted mutational analysis of inflammatory bowel disease-associated colorectal cancers.

    abstract::Inflammatory bowel disease-associated colorectal carcinomas (IBD-CRCs) develop in a background of chronic inflammation, and thus, the molecular landscape of these tumors likely differs from that of sporadic colorectal cancer. To add to emerging data on molecular alterations present in these tumors, we analyzed our ins...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Alpert L,Yassan L,Poon R,Kadri S,Niu N,Patil SA,Mujacic I,Montes D,Galbo F,Wurst MN,Zhen CJ,Cohen RD,Rubin DT,Pekow JR,Weber CR,Xiao SY,Hart J,Segal J,Setia N

    更新日期:2019-07-01 00:00:00

  • Low papillary structure in lepidic growth component of lung adenocarcinoma: a unique histologic hallmark of aggressive behavior.

    abstract::Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto M

    更新日期:2013-09-01 00:00:00

  • Identification of immunophenotypic subtypes with different prognoses in extranodal natural killer/T-cell lymphoma, nasal type.

    abstract::To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yu JB,Zuo Z,Zhang WY,Yang QP,Zhang YC,Tang Y,Zhao S,Mo XM,Liu WP

    更新日期:2014-11-01 00:00:00

  • Epstein-Barr virus-associated lymphoproliferative disorders.

    abstract::Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Rezk SA,Weiss LM

    更新日期:2007-09-01 00:00:00

  • IMP3 expression is associated with poor survival in cervical squamous cell carcinoma.

    abstract::Insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3) is an oncofetal protein that promotes tumor progression and metastasis in a number of malignancies. However, the clinical significance of IMP3 expression in squamous cell carcinoma (SCC) of the uterine cervix is unclear. In this study, the cor...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wei Q,Yan J,Fu B,Liu J,Zhong L,Yang Q,Zhao T

    更新日期:2014-11-01 00:00:00

  • Colloid cysts of the third ventricle: immunohistochemical evidence for nonneuroepithelial differentiation.

    abstract::The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tsuchida T,Hruban RH,Carson BS,Phillips PC

    更新日期:1992-07-01 00:00:00

  • Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.

    abstract::Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Miettinen MM,Antonescu CR,Fletcher CDM,Kim A,Lazar AJ,Quezado MM,Reilly KM,Stemmer-Rachamimov A,Stewart DR,Viskochil D,Widemann B,Perry A

    更新日期:2017-09-01 00:00:00

  • The gastric hypercellular microleiomyoma as a precursor lesion for clinical gastrointestinal stromal tumors.

    abstract::Differentiation features and proliferation activity of 67 gastric microleiomyomas (microLMs) and 53 clinical gastrointestinal stromal tumors (GISTs) of the stomach were compared. The 67 microLMs were divided into two categories on the basis of cellularity: 53 hypocellular and 14 hypercellular types, and the 39 GISTs w...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Mikami T,Terada T,Nakamura K,Okayasu I

    更新日期:1997-12-01 00:00:00

  • Cytogenetic studies of composite lymphomas: monocytoid B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.

    abstract::Monocytoid B-cell lymphoma (MBCL) is a newly recognized, morphologically and immunologically distinct, low-grade B-cell neoplasm that may exist as a pure morphologic entity or as a component of a composite lymphoma. To determine whether cytogenetic abnormalities exist in cases of MBCL, fresh tissue from four lymphoma ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Slovak ML,Weiss LM,Nathwani BN,Bernstein L,Levine AM

    更新日期:1993-10-01 00:00:00

  • Cytomegalovirus-associated cutaneous vasculopathy and scleroderma sans inclusion body change.

    abstract::Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV in...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Magro CM,Crowson AN,Ferri C

    更新日期:2007-01-01 00:00:00

  • Aberrant expression of δ-like ligand 4 contributes significantly to axillary lymph node metastasis and predicts postoperative outcome in breast cancer.

    abstract::δ-Like ligand 4 (DLL4), a ligand for the Notch family of receptors, forecasts the prognosis of several human malignancies. However, the expression and role of DLL4 in breast cancer remain largely unknown. In the present study, we first evaluated whether the overexpression of DLL4 could be used as an indicator of axill...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Xiao M,Yang S,Ning X,Huang Y

    更新日期:2014-11-01 00:00:00

  • Diagnosis of congenital syphilis from placental examination: comparison of histopathology, Steiner stain, and polymerase chain reaction for Treponema pallidum DNA.

    abstract::Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Genest DR,Choi-Hong SR,Tate JE,Qureshi F,Jacques SM,Crum C

    更新日期:1996-04-01 00:00:00

  • Clonal and genetic relationship between individual components of mucoepidermoid carcinoma: X-chromosome inactivation assay and microsatellite analysis.

    abstract::Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wang W,Zou B,Zhu H,Bao Y

    更新日期:2016-10-01 00:00:00

  • Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes.

    abstract::Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Choi HR,Sturgis EM,Rashid A,DeMonte F,Luna MA,Batsakis JG,El-Naggar AK

    更新日期:2003-11-01 00:00:00

  • Crystalline light chain proximal tubulopathy with chronic renal failure and silicone gel breast implants: 1 case report.

    abstract::A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Figueres ML,Beaume J,Vuiblet V,Rabant M,Bassilios N,Herody M,Touchard G,Noël LH

    更新日期:2015-01-01 00:00:00

  • Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.

    abstract::High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Roger P,Montcourrier P,Maudelonde T,Brouillet JP,Pages A,Laffargue F,Rochefort H

    更新日期:1994-09-01 00:00:00

  • Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases.

    abstract::Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental abnormalities, tissue overgrowth, ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Zynger DL,Gupta A,Luan C,Chou PM,Yang GY,Yang XJ

    更新日期:2008-02-01 00:00:00

  • Brainstem subarachnoid respiratory epithelial cysts: report of two cases and review of the literature.

    abstract::Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Schelper RL,Kagan-Hallet KS,Huntington HW

    更新日期:1986-04-01 00:00:00

  • New observations on the etiology of aortic valve disease: a surgical pathologic study of 236 cases from 1990.

    abstract::Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Dare AJ,Veinot JP,Edwards WD,Tazelaar HD,Schaff HV

    更新日期:1993-12-01 00:00:00