Practical use of electron microscopy for the diagnosis of glomerular disease.

abstract：:Benign lymphocytic angiitis and granulomatosis is a T-cell lymphoproliferative disorder confined to the lung and corresponding to a low-grade angiocentric immunoproliferative lesion. Controversy remains as to whether these lesions are lymphomas. We report such a case in an 8-year-old patient with Burkitt's lymphoma in...

journal_title：Human pathology

authors： Vergier B,Capron F,Trojani M,Labouyrie E,Ferrer J,Eghbali H,Merlio JP,de Mascarel A

更新日期：1992-10-01 00:00:00

abstract：:In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...

journal_title：Human pathology

authors： Munfus-McCray D,Harada S,Adams C,Askin F,Clark D,Gabrielson E,Li QK

更新日期：2011-10-01 00:00:00

abstract：:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is...

journal_title：Human pathology

authors： Arora K,Miller R,Mullick S,Shen S,Ayala AG,Ro JY

更新日期：2018-01-01 00:00:00

abstract：:After multiple fragmentation of neoplastic nuclei into "nucleotesimals," a recently discovered variety of amitosis, some fragments appear to be inflated to full nuclear size; other probably lyse, releasing nucleic acid, which may assist in the synthesis of new cytoplasm around newly formed nuclei. This observation may...

journal_title：Human pathology

authors： Elias H,Hyde DM

更新日期：1982-07-01 00:00:00

abstract：:Although the therapeutic outcome of osteosarcoma patients has improved dramatically within the last 20 years because of combined neoadjuvant chemotherapy and surgery, the problem of drug resistance remains. Thus far, markers that can predict the response to chemotherapy at the time of biopsy are not available. Heat sh...

journal_title：Human pathology

authors： Trieb K,Lechleitner T,Lang S,Windhager R,Kotz R,Dirnhofer S

更新日期：1998-10-01 00:00:00

abstract：:Thirty-nine mammographically detected, (M-detected) small invasive carcinomas of the breast (< or = 5 mm) were compared with 78 consecutive clinical cancers (> or = 10 mm) for a variety of morphological and biological markers of prognostic importance. There were more tubular carcinomas in the M-detected group (12.8% v...

journal_title：Human pathology

authors： Moezzi M,Melamed J,Vamvakas E,Inghirami G,Mitnick J,Quish A,Bose S,Zelman G,Roses D,Harris M,Feiner H

更新日期：1996-09-01 00:00:00

abstract：:Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...

journal_title：Human pathology

authors： Doss BJ,Jacques SM,Qureshi F,Ramirez NC,Lawrence WD

更新日期：1998-02-01 00:00:00

abstract：:Endothelial cell injury may contribute to the progression of various glomerular diseases. In the present study, we examined glomerular capillary injury in acute and chronic glomerular lesions in patients with Immunoglobulin A nephropathy (IgAN). We selected renal biopsy samples of IgAN (n = 200), and glomerular capill...

journal_title：Human pathology

authors： Kusano T,Takano H,Kang D,Nagahama K,Aoki M,Morita M,Kaneko T,Tsuruoka S,Shimizu A

更新日期：2016-03-01 00:00:00

abstract：:Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...

journal_title：Human pathology

authors： Tian Z,Wei B,Tang F,Wei W,Gilcrease MZ,Huo L,Albarracin CT,Resetkova E,Middleton L,Sahin A,Xing Y,Hunt KK,Chen J,Bu H,Rashid A,Abraham SC,Wu Y

更新日期：2011-08-01 00:00:00

abstract：:Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...

journal_title：Human pathology

authors： Machen SK,Prayson RA

更新日期：1998-12-01 00:00:00

abstract：:Mucin core proteins (MUCs) are expressed in tissue-specific patterns in the gastrointestinal tract and expression is deregulated in Barrett's metaplasia. Based on differential expression, MUCs have been used to classify adenocarcinomas into distinct phenotypes (eg, intestinal, gastric, pancreaticobiliary, etc). Becaus...

journal_title：Human pathology

authors： Davison JM,Ellis ST,Foxwell TJ,Luketich JD,Gibson MK,Kuan SF,Nason KS

更新日期：2014-03-01 00:00:00

abstract：:Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...

journal_title：Human pathology

authors： Magro C,Crowson AN,Kovatich A,Burns F

更新日期：2002-08-01 00:00:00

abstract：:Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...

journal_title：Human pathology

authors： Zhang JF,Chen Y,Lin GS,Zhang JD,Tang WL,Huang JH,Chen JS,Wang XF,Lin ZX

更新日期：2016-06-01 00:00:00

abstract：:Most failures of bioprosthetic heart valves in children are due to stenosis secondary to thrombus, calcific deposits, or tissue ingrowth. Valve failures due to regurgitation typically involve cuspal detachment, tears, or perforations. We present four cases of prosthetic valve regurgitation in children caused by cuspal...

journal_title：Human pathology

authors： Murphy SK,Rogler WC,Fleming WH,McManus BM

更新日期：1988-02-01 00:00:00

abstract：:All cases of primary breast carcinoma seen at the George Washington University Medical Center between 1971 and 1975 and between 1981 and 1986 were reviewed, and examples of pure and mixed infiltrating cribriform carcinoma (ICC) were identified. The relative frequency of ICC did not change significantly from the earlie...

journal_title：Human pathology

authors： Venable JG,Schwartz AM,Silverberg SG

更新日期：1990-03-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....

journal_title：Human pathology

authors： Pierson CR,Schober MS,Wallis T,Sarkar FH,Sorensen PH,Eble JN,Srigley JR,Jones EC,Grignon DJ,Adsay V

更新日期：2001-05-01 00:00:00

abstract：:This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...

journal_title：Human pathology

authors： Wu Y,Wang T,Ye S,Zhao R,Bai X,Wu Y,Abe K,Jin X

更新日期：2012-01-01 00:00:00

abstract：:Increasing differentiation in the human endometrium is associated with an apparent decrease in intercellular contacts between endometrial stromal cells ...

journal_title：Human pathology

authors： Parmley TH,Roberts DK,Emsa NJ,Horbelt DV

更新日期：1990-10-01 00:00:00

abstract：:Congenital cystic airway malformation/congenital pulmonary airway malformation (CCAM/CPAM) of the lung is a rare but well-described malformative lesion of pulmonary parenchyma characterized by the abnormal maturation of airways along with an increase in terminal respiratory structures, resulting in cysts of variable s...

journal_title：Human pathology

authors： Guo H,Cajaiba MM,Borys D,Gutierrez MC,Yee H,Drut RM,Drut R,Askin F,Reyes-Múgica M,Greco MA

更新日期：2007-12-01 00:00:00

abstract：:Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...

journal_title：Human pathology

authors： Giltman L,Alderete M,Minkowitz S

更新日期：1977-11-01 00:00:00

abstract：:Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...

journal_title：Human pathology

authors： Klieser E,Urbas R,Stättner S,Primavesi F,Jäger T,Dinnewitzer A,Mayr C,Kiesslich T,Holzmann K,Di Fazio P,Neureiter D,Swierczynski S

更新日期：2017-07-01 00:00:00

abstract：:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and d...

journal_title：Human pathology

authors： Kamel OW,Horoupian DS,Silverberg GD

更新日期：1989-12-01 00:00:00

abstract：:Alterations in the Notch signaling pathway play a role in colorectal cancer (CRC). Hes1, a Notch-induced transcription factor, has recently been reported to show decreased expression by immunohistochemistry in sessile serrated adenomas. Variable staining patterns have been reported in tubular adenomas, and existing da...

journal_title：Human pathology

authors： Ahadi M,Andrici J,Sioson L,Sheen A,Clarkson A,Gill AJ

更新日期：2016-11-01 00:00:00

abstract：:A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-l...

journal_title：Human pathology

authors： Love GL,Daroca PJ Jr

更新日期：1983-11-01 00:00:00

abstract：:We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...

journal_title：Human pathology

authors： Hennell C,Jamison J,Wells M,McCluggage WG

更新日期：2012-03-01 00:00:00

abstract：:Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...

journal_title：Human pathology

authors： Hyjek E,Isaacson PG

更新日期：1988-11-01 00:00:00

abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...

journal_title：Human pathology

authors： Cornejo KM,Cheng L,Church A,Wang M,Jiang Z

更新日期：2016-03-01 00:00:00

abstract：:Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

journal_title：Human pathology

authors： Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

更新日期：2016-10-01 00:00:00

abstract：:A 48-year-old man with a history of recurrent urolithiasis and chronic renal failure underwent a nephrectomy for a renal mass. At surgery the mass proved to be a calculus impacted in a dilated calyx. Gross examination of the kidney revealed chalky white deposits in the deep medulla and papillary tips. Histologic exami...

journal_title：Human pathology

authors： Gelb AB,Fye KH,Tischfield JA,Sahota AS,Sparks JW,Hancock DC,Sibley RK

更新日期：1992-09-01 00:00:00

abstract：:Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinom...

journal_title：Human pathology

authors： Ji J,Zheng PS

更新日期：2010-10-01 00:00:00