Abstract:
:All cases of primary breast carcinoma seen at the George Washington University Medical Center between 1971 and 1975 and between 1981 and 1986 were reviewed, and examples of pure and mixed infiltrating cribriform carcinoma (ICC) were identified. The relative frequency of ICC did not change significantly from the earlier to the later study period. As previously reported by Page et al, there was a tendency for ICC to be associated with foci of tubular carcinoma and of intraductal carcinoma (often but not always of cribriform type). Pure ICC (defined as showing no other infiltrating carcinoma type), predominant ICC with lesser amounts of infiltrating carcinoma of any other type and any quantitative combination of ICC and tubular carcinoma metastasized to axillary lymph nodes frequently, but almost never to more than three nodes, in contradistinction to tumors composed of infiltrating duct carcinoma (IDC) not otherwise specified and less than 50% ICC, and a control group of IDC, which significantly more often involved four or more nodes. ICC cases were estrogen-receptor-positive in 100% and progesterone-receptor-positive in 69% of the cases. Five-year survival rates for eligible cases were 100% for pure and greater than or equal to 50% ICC, 88% for less than 50% ICC, and 78.3% for the IDC controls. ICC is a histologically and clinically distinctive type of mammary carcinoma that should be separated from IDC and other tumor types.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Venable JG,Schwartz AM,Silverberg SGdoi
10.1016/0046-8177(90)90235-wsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
333-8issue
3eissn
0046-8177issn
1532-8392pii
0046-8177(90)90235-Wjournal_volume
21pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.010
更新日期:2011-11-01 00:00:00
abstract::A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90030-8
更新日期:1999-10-01 00:00:00
abstract::We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90120-6
更新日期:1993-09-01 00:00:00
abstract::We introduce a novel hybrid telepathology system providing simultaneous transmission of both real-time microscopy and static imagery at a reasonable cost. It is capable of capturing static, true color images at resolution of 1,520 x 1,144 pixels and providing live transmission of real-time video images of the glass sl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9196
更新日期:2000-07-01 00:00:00
abstract::A 64-year-old man with pseudosarcoma of the esophagus is described. Morphologic examinations of this rare tumor were made, and the origin of the sarcoma-like cells of the tumor is discussed. The findings for the sarcoma-like cells of the tumor support the idea that the sarcoma-like elements arose through transformatio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80036-1
更新日期:1982-05-01 00:00:00
abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90215-3
更新日期:1993-11-01 00:00:00
abstract::Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for rela...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.07.011
更新日期:2006-12-01 00:00:00
abstract::Congenital cystic adenomatoid malformation (CCAM) of the lung is a congenital lesion that is sometimes complicated by bronchioloalveolar adenocarcinoma (BAC). In some cases foci of atypical goblet cell hyperplasia (AGCH) can be found within the cysts. It has been proposed that CCAM and AGCH predispose to the developme...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.01.008
更新日期:2004-05-01 00:00:00
abstract::Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/j.humpath.2003.08.024
更新日期:2003-11-01 00:00:00
abstract::In the past few years many clinically significant new glomerular lesions have been reported from observations made on renal biopsy specimens by electron microscopy. The clinical applicability of electron microscopy is illustrated by examples of specific ultrastructural patterns of glomerular reaction making possible a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(75)80060-8
更新日期:1975-07-01 00:00:00
abstract::The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.11.022
更新日期:2019-04-01 00:00:00
abstract::Neoglycoproteins are readily available conjugates of a histochemically inert carrier protein and histochemically crucial carbohydrate moieties which are covalently attached to the carrier protein by chemical synthesis. Biotinylation renders these conjugates detectable in formalin-fixed, paraffin-embedded tissue sectio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90045-2
更新日期:1989-04-01 00:00:00
abstract::Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.03.008
更新日期:2014-08-01 00:00:00
abstract::Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.032
更新日期:2006-06-01 00:00:00
abstract::The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90238-x
更新日期:1992-02-01 00:00:00
abstract::Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.27115
更新日期:2001-09-01 00:00:00
abstract::The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80099-3
更新日期:1982-11-01 00:00:00
abstract::The diagnosis of placental site trophoblastic lesions, particularly the distinction of a placental site trophoblastic tumor from an exaggerated placental site, can be difficult. Mel-CAM (also known as CD146 and MUC18) is a recently recognized cell adhesion molecule belonging to the immunoglobin gene superfamily that s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90386-0
更新日期:1998-01-01 00:00:00
abstract::Collapsing glomerulopathy (CG), an aggressive variant of focal segmental glomerular sclerosis, is a renal disease with severe proteinuria and rapidly progressive renal failure. The pathogenesis of CG is unknown. It strongly resembles human immunodeficiency virus (HIV)-associated nephropathy, but the patients are HIV n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.124333
更新日期:2002-04-01 00:00:00
abstract::Prior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investigate the relationsh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.05.009
更新日期:2012-03-01 00:00:00
abstract::Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90084-1
更新日期:1994-12-01 00:00:00
abstract::To examine the hypothesis that malpositions of cardiac ventricles could be explained by altered development of the interventricular septum, we studied hearts from the Johns Hopkins Hospital autopsy files with double inlet left ventricle (16 cases) or corrected transposition (nine cases). In double inlet left ventricle...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80125-6
更新日期:1981-03-01 00:00:00
abstract::Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.031
更新日期:2016-02-01 00:00:00
abstract::CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.029
更新日期:2017-06-01 00:00:00
abstract::Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.06.003
更新日期:2009-12-01 00:00:00
abstract::Eight cases of primary mesenchymal renal tumor in infants under one year of age were studied. The patients' ages ranged from one day to seven months; all but one were diagnosed within the first three months of life. There were four typical congenital mesoblastic nephromas. Two malignant mesenchymal, one intermediate c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80244-4
更新日期:1981-01-01 00:00:00
abstract::We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.03.011
更新日期:2012-03-01 00:00:00
abstract::Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2004.02.007
更新日期:2004-06-01 00:00:00
abstract::In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...
journal_title:Human pathology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.humpath.2005.02.001
更新日期:2005-04-01 00:00:00