Abstract：
:Neoglycoproteins are readily available conjugates of a histochemically inert carrier protein and histochemically crucial carbohydrate moieties which are covalently attached to the carrier protein by chemical synthesis. Biotinylation renders these conjugates detectable in formalin-fixed, paraffin-embedded tissue sections of human lung cancer by standard staining protocols, thereby localizing endogenous receptors for carbohydrate moieties. Examination of 30 cases of main types of human lung cancer revealed the presence of alpha-fucosyl-, alpha-mannosyl-, and alpha-glucosyl-specific receptors in adenocarcinomas or epidermoid carcinomas with high positivity rates. The extent of the expression of receptors for alpha- and beta-galactosides appeared to be comparatively lower. Within the standard protocol, using a concentration of the biotinylated probes of 10 micrograms/mL, this panel of probes consistently failed to detect endogenous sugar receptors in ten cases of small cell anaplastic carcinoma of the lung. Whereas none of the sections from the tumor cases bound the sulfated fucan fucoidan, the accompanying inflammatory cells, especially the granulocytes, expressed receptors for the sulfated fucan. Pronounced labeling for macrophages was observed for the alpha-galactoside-specific probe, whereas no binding to inflammatory cells and pneumocytes was detectable for the beta-galactoside-specific probe. The results indicate that expression of endogenous receptors for neoglycoproteins may be useful in discriminating between small cell and non-small cell lung carcinoma and carcinomatous cells from accompanying inflammatory cells.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kayser K,Gabius HJ,Ciesiolka T,Ebert W,Bach Sdoi
10.1016/0046-8177(89)90045-2subject
Has Abstractpub_date
1989-04-01 00:00:00pages
352-60issue
4eissn
0046-8177issn
1532-8392pii
0046-8177(89)90045-2journal_volume
20pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The clinicopathologic features and immunohistochemical profiles of 14 cases of a distinctive mesenchymal tumor that arises in the superficial lamina propria of the cervix and vagina and is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including the cellular (pseudosarcomatous) variant...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.25588
更新日期：2001-07-01 00:00:00
abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90185-4
更新日期：1997-06-01 00:00:00
abstract：:Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80003-2
更新日期：1976-01-01 00:00:00
abstract：:We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.03.011
更新日期：2012-03-01 00:00:00
abstract：:Differentiation features and proliferation activity of 67 gastric microleiomyomas (microLMs) and 53 clinical gastrointestinal stromal tumors (GISTs) of the stomach were compared. The 67 microLMs were divided into two categories on the basis of cellularity: 53 hypocellular and 14 hypercellular types, and the 39 GISTs w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90223-9
更新日期：1997-12-01 00:00:00
abstract：:The previously unreported association of granulomatous gastritis and mononeuritis multiplex occurring in the setting of a vasculitic syndrome is described. The two conditions are considered to be associated and to be immune mediated. The previously accepted concept of isolated granulomatous gastritis is disputed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90018-k
更新日期：1991-10-01 00:00:00
abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.11.004
更新日期：2012-09-01 00:00:00
abstract：:We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(91)90106-y
更新日期：1991-12-01 00:00:00
abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.005
更新日期：2009-11-01 00:00:00
abstract：:Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated pro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.01.010
更新日期：2017-07-01 00:00:00
abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90303-9
更新日期：1999-01-01 00:00:00
abstract：:A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2009.06.017
更新日期：2010-03-01 00:00:00
abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00121-7
更新日期：2003-05-01 00:00:00
abstract：:Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.humpath.2017.03.023
更新日期：2017-06-01 00:00:00
abstract：:The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.11.002
更新日期：2012-09-01 00:00:00
abstract：:SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.05.024
更新日期：2017-12-01 00:00:00
abstract：:We have experienced an autopsy case of a 20-year-old woman with bronchiolitis obliterans, pemphigus vulgaris, and Castleman's disease. The affected bronchioles showed almost the same histology as previously described. But, the number of the lesions seemed too small to cause her death of respiratory insufficiency. We a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90208-2
更新日期：1997-11-01 00:00:00
abstract：:Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.06.019
更新日期：2008-03-01 00:00:00
abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.02.007
更新日期：2004-06-01 00:00:00
abstract：:Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90096-l
更新日期：1992-04-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:The genetic diagnosis of Gaucher disease by molecular methods is complicated by the existence of a highly homologous transcribed pseudogene (96% identity) that is found in close proximity to the true gene on chromosome 1q21. In addition, the pseudogene sequence can mimic disease-causing mutations in the true gene. Sel...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.11.006
更新日期：2004-04-01 00:00:00
abstract：:The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80080-9
更新日期：1981-09-01 00:00:00
abstract：:Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80022-7
更新日期：1983-03-01 00:00:00
abstract：:Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90349-4
更新日期：1996-12-01 00:00:00
abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:We have previously shown that necrotic tumors retain their immunoreactivity for a range of cytokeratin antibodies. Some thyroid tumors undergo extensive necrosis after fine-needle aspiration (FNA) procedures. We evaluated the sensitivity of antibodies on necrotic thyroid tumors by examining a series of thyroid tumors ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90071-0
更新日期：1999-11-01 00:00:00
abstract：:Endolymphatic sac tumor (ELST) is a low-grade adenocarcinoma of the temporal bone that is presumed to originate from the endolymphatic system. Although ELSTs are extremely rare in the general population, a significant number of studies have documented the occurrence of ELST among patients with von Hippel-Lindau (VHL) ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.28961
更新日期：2001-11-01 00:00:00
abstract：:We describe a case of simultaneous nodular sclerosing Hodgkin's disease and a granulocytic sarcoma in a cervical lymph node without any previous therapy. The condition evolved into acute myelogenous leukemia approximately 8 months after the initial diagnosis of the granulocytic sarcoma. The unexpected presence of a gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90293-2
更新日期：1996-10-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.009
更新日期：2004-09-01 00:00:00
