Abstract：
:Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its unique expression pattern limited to tumor-associated endothelial cells, PSMA may also be an interesting molecule for vascular targeting. In this study, PSMA expression was determined by immunohistochemistry in 119 cases of primary gastric adenocarcinoma, 130 cases of primary colorectal adenocarcinoma, and 24 metastasis of colorectal adenocarcinoma. Expression data were correlated with clinicopathologic information. PSMA expression was detected in tumor-associated neovasculature of 79 (66%) of 119 gastric and 110 (85%) of 130 colorectal carcinomas. Furthermore, the neovasculatures of 16 (84%) of 19 liver and 4 (80%) of 5 nodal metastases from colorectal carcinomas were prostate-specific membrane antigen positive. There was a trend for high-grade tumors to higher PSMA expression (Spearman r = 0.18, P = .046) in colorectal cancers. No association between PSMA expression and overall- or disease-free survival was observed in gastric or colorectal cancers. This study provides the first in-depth look at PSMA expression in gastric and colorectal cancer. Because of its highly tumor-restricted expression and its accessibility to targeted therapy, PSMA represents a promising therapeutic and diagnostic target in colorectal and gastric cancer.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Haffner MC,Kronberger IE,Ross JS,Sheehan CE,Zitt M,Mühlmann G,Ofner D,Zelger B,Ensinger C,Yang XJ,Geley S,Margreiter R,Bander NHdoi
10.1016/j.humpath.2009.06.003subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1754-61issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(09)00207-Xjournal_volume
40pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Reactive bone marrow mast cells reliably lack the morphologic, immunophenotypic, and molecular features of systemic mastocytosis (SM). We report two unusual cases of acquired aplastic anemia (AA) in which multifocal aggregates of bone marrow mast cells fulfilled morphologic and immunophenotypic criteria for SM accordi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.08.002
更新日期：2014-02-01 00:00:00
abstract：:Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.11.013
更新日期：2007-05-01 00:00:00
abstract：:The concurrent presence of JAK2 V617F, monocytosis, and bone marrow fibrosis can be observed in both chronic myelomonocytic leukemia (CMML) and primary myelofibrosis (PMF). It can be challenging to distinguish CMML with JAK2 mutation and fibrosis from other myeloid neoplasms, particularly PMF. To identify key features...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.10.026
更新日期：2019-03-01 00:00:00
abstract：:Renal cell carcinoma (RCC) is known to have a wide variation in clinical outcome despite the use of conventional prognostic factors, such as staging or grading. A better knowledge of the biologic aggressiveness of RCC could facilitate the selection of patients at high risk of tumor progression. The aim of this study w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.28957
更新日期：2001-11-01 00:00:00
abstract：:Plasmacytoid dendritic cells, which play a fundamental role in the innate immune response, are best known for their presence in hyaline-vascular Castleman disease and histiocytic necrotizing lymphadenitis. The relative number and distribution in many reactive entities as detected using more sensitive methods are uncer...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.08.020
更新日期：2013-06-01 00:00:00
abstract：:Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides. Each showed diffuse staining for NSE. Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enk...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80314-9
更新日期：1988-01-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.05.013
更新日期：2015-09-01 00:00:00
abstract：:The use of interleukin-2 (IL-2), either alone or in combination with lymphokine-activated killer cells, tumor infiltrating lymphocytes, or other immunotherapeutic agents has added a new list of alternatives to conventional antineoplastic regimens. Little information is available about the pathologic changes occurring ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90005-p
更新日期：1990-05-01 00:00:00
abstract：:Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.11.018
更新日期：2008-08-01 00:00:00
abstract：:Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.02.013
更新日期：2010-10-01 00:00:00
abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90233-1
更新日期：1997-12-01 00:00:00
abstract：:We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.010
更新日期：2007-06-01 00:00:00
abstract：:In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.011
更新日期：2011-10-01 00:00:00
abstract：:We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.05.015
更新日期：2005-07-01 00:00:00
abstract：:Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.11.011
更新日期：2006-03-01 00:00:00
abstract：:The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90352-4
更新日期：1992-07-01 00:00:00
abstract：:Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90084-t
更新日期：1993-04-01 00:00:00
abstract：:SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human mal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.28244
更新日期：2001-10-01 00:00:00
abstract：:Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.008
更新日期：2004-09-01 00:00:00
abstract：:The diagnosis of metastatic adenocarcinoma to the brain of unknown primary is problematic, and the role of immunohistochemistry in identifying a source has not been fully characterized. Sixty-eight metastatic adenocarcinomas of the brain with known primaries were immunostained with antibodies to cytokeratin 7 (CK7), c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90009-5
更新日期：1997-08-01 00:00:00
abstract：:The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.017
更新日期：2010-11-01 00:00:00
abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.011
更新日期：2005-03-01 00:00:00
abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.015
更新日期：2012-09-01 00:00:00
abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.06.002
更新日期：2013-03-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other typ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80185-x
更新日期：1986-07-01 00:00:00
abstract：:Renal biopsy specimens from 19 patients with asymptomatic hematuria, normal glomeruli on light microscopic examination, and negative immunofluorescence were studied to characterize the ultrastructural changes of the glomerular basement membrane. Three groups of patients were identified. Four patients (group 1) had typ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80180-4
更新日期：1983-11-01 00:00:00
abstract：:Astrocytoma grade IV (glioblastoma multiforme) is the most common and most malignant tumor of the central nervous system and is currently noncurable. Here, we have examined a population-based cohort of 47 patients with grade IV astrocytoma, who underwent tumor surgery at Sahlgrenska University Hospital in Sweden and w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.013
更新日期：2013-10-01 00:00:00
abstract：:Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.011
更新日期：2015-02-01 00:00:00
abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80243-8
更新日期：1982-12-01 00:00:00
