Basement membrane nephropathy: a new classification for Alport's syndrome and asymptomatic hematuria based on ultrastructural findings.

abstract：:In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...

journal_title：Human pathology

authors： Lugli A,Lugli AK,Horcic M

更新日期：2005-04-01 00:00:00

abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...

journal_title：Human pathology

authors： Nasir A,Amateau SK,Khan S,Simpson RW,Snover DC,Amin K

更新日期：2018-04-01 00:00:00

abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...

journal_title：Human pathology

authors： Boiocchi L,Hasserjian RP,Pozdnyakova O,Wong WJ,Lennerz JK,Le LP,Dias-Santagata D,Iafrate AJ,Hobbs GS,Nardi V

更新日期：2019-04-01 00:00:00

abstract：:The clinicopathologic features and immunohistochemical profiles of 14 cases of a distinctive mesenchymal tumor that arises in the superficial lamina propria of the cervix and vagina and is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including the cellular (pseudosarcomatous) variant...

journal_title：Human pathology

authors： Laskin WB,Fetsch JF,Tavassoli FA

更新日期：2001-07-01 00:00:00

abstract：:Adenomatous hyperplasia, a hyperplastic parenchymal nodule in the cirrhotic liver, has been presumed to be a preneoplastic lesion in human hepatocarcinogenesis. In this study, phenotypes of the sinusoidal endothelium were examined in adenomatous hyperplasia, hepatocellular carcinoma, cirrhosis, chronic active hepatiti...

journal_title：Human pathology

authors： Terada T,Nakanuma Y

更新日期：1991-05-01 00:00:00

abstract：:Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful...

journal_title：Human pathology

authors： Segal GH,Jorgensen T,Masih AS,Braylan RC

更新日期：1994-12-01 00:00:00

abstract：:The case of a 65-year-old female patient with a pedunculated left atrial angiosarcoma is presented. Histologically, the tumor was composed of vascular spaces lined by atypical cells with similar cells in the solid portion of the tumor. Immunohistochemical stain for factor VIII-related antigen was positive in the cells...

journal_title：Human pathology

authors： Keohane ME,Lazzam C,Halperin JL,Strauchen JA,Ergin MA

更新日期：1989-06-01 00:00:00

abstract：:Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...

journal_title：Human pathology

authors： Sandhu R,Chollet-Hinton L,Kirk EL,Midkiff B,Troester MA

更新日期：2016-02-01 00:00:00

abstract：:Two episodes of severe, relapsing sensorimotor polyneuropathy closely paralleled the course of systemic illness in a patient with immunoblastic lymphadenopathy. A review of the literature shows three other cases, although none with documented pathologic changes in muscles and nerves. Based on the pathologic findings i...

journal_title：Human pathology

authors： Cytowic RE,Challa VR,Buss DH,Angelo JN

更新日期：1982-02-01 00:00:00

abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...

journal_title：Human pathology

authors： Thurberg BL,Politei JM

更新日期：2012-04-01 00:00:00

abstract：:Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...

journal_title：Human pathology

authors： Tsai MS,Hsieh MS,Huang HY,Huang PH

更新日期：2019-02-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...

journal_title：Human pathology

authors： Engels EA,Mbulaiteye SM,Othieno E,Gomez M,Mathew S,Cesarman E,Knowles DM,Chadburn A

更新日期：2007-02-01 00:00:00

abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...

journal_title：Human pathology

authors： Shahi M,Bloechl SJ,Vogel RI,Shrestha R,Krigman HR,Evasovich M,Burmeister LA,Amin K

更新日期：2019-11-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...

journal_title：Human pathology

authors： Kumazaki K,Nakayama M,Suehara N,Wada Y

更新日期：2002-11-01 00:00:00

abstract：:Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed....

journal_title：Human pathology

authors： Alpers CE,Tu WH,Hopper J Jr,Biava CG

更新日期：1985-03-01 00:00:00

abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...

journal_title：Human pathology

authors： Yang XJ,Tretiakova MS,Sengupta E,Gong C,Jiang Z

更新日期：2003-05-01 00:00:00

abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

journal_title：Human pathology

authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

更新日期：2010-03-01 00:00:00

abstract：:The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...

journal_title：Human pathology

authors： de Micco C,Chapel F,Dor AM,Garcia S,Ruf J,Carayon P,Henry JF,Lebreuil G

更新日期：1993-03-01 00:00:00

abstract：:Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...

journal_title：Human pathology

authors： Polesky HF,Lasky LC

更新日期：1983-03-01 00:00:00

abstract：:Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in neurons of the central and peripheral nervous system. We report a boy with onset of disease manifestations at age 3 and death at age 9, who showed c...

journal_title：Human pathology

authors： Oyer CE,Cortez S,O'Shea P,Popovic M

更新日期：1991-07-01 00:00:00

abstract：:In this review we summarize recent advances in the histopathological diagnostic criteria and molecular pathology of the main subtypes of ovarian surface epithelial carcinoma. These advances have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management. With pro...

journal_title：Human pathology

authors： Gilks CB,Prat J

更新日期：2009-09-01 00:00:00

abstract：:Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...

journal_title：Human pathology

authors： Takeshita M,Ohshima K,Akamatsu M,Ohgami A,Kikuchi M,Suzumiya J,Uike N,Okamura T,Nakayama J

更新日期：1995-06-01 00:00:00

abstract：:We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound st...

journal_title：Human pathology

authors： Baergen RN,Kelly T,McGinniss MJ,Jones OW,Benirschke K

更新日期：1996-07-01 00:00:00

abstract：:Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations pr...

journal_title：Human pathology

authors： McDaniel AS,Zhai Y,Cho KR,Dhanasekaran SM,Montgomery JS,Palapattu G,Siddiqui J,Morgan T,Alva A,Weizer A,Lee CT,Chinnaiyan AM,Quist MJ,Grasso CS,Tomlins SA,Mehra R

更新日期：2014-09-01 00:00:00

abstract：:Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...

journal_title：Human pathology

authors： Wang NS,Seemayer TA,Ahmed MN,Knaack J

更新日期：1976-01-01 00:00:00

abstract：:Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...

journal_title：Human pathology

authors： Hu M,Li K,Maskey N,Xu Z,Yu F,Peng C,Li Y,Yang G

更新日期：2015-12-01 00:00:00

abstract：:We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...

journal_title：Human pathology

authors： Knowles DM,Wolff M

更新日期：1976-09-01 00:00:00

abstract：:A practical approach to the interpretation of peroral small intestinal biopsy specimens is presented. Biopsy technique and tissure handling are described. Interpretation of normal and abnormal biopsy specimens is discussed. A practical classification of abnormal small intestinal biopsies is presented and illustrated. ...

journal_title：Human pathology

authors： Perera DR,Weinstein WM,Rubin CE

更新日期：1975-03-01 00:00:00

abstract：:Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited. This study was carried out to evaluate the frequency of BRAF V600E ...

journal_title：Human pathology

authors： Chatterjee D,Garg C,Singla N,Radotra BD

更新日期：2018-10-01 00:00:00

abstract：:Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on...

journal_title：Human pathology

authors： Kim MS,In SG,Park OJ,Won CH,Lee MW,Choi JH,Kim CW,Kim SE,Moon KC,Chang S

更新日期：2011-07-01 00:00:00