Abstract：
:Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms, which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma (UCA). Here, we evaluated for the presence of common driving somatic mutations and HPV within a cohort of IUPs, (n = 7) noninvasive low-grade papillary UCAs with inverted growth pattern (n = 5), and noninvasive high-grade papillary UCAs with inverted growth pattern (n = 8). HPV was not detected in any case of IUP or inverted UCA by either in situ hybridization or by polymerase chain reaction. Next-generation sequencing identified recurrent mutations in HRAS (Q61R) in 3 of 5 IUPs, described for the first time in this neoplasm. Additional mutations of Ras pathway members were detected including HRAS, KRAS, and BRAF. The presence of Ras pathway member mutations at a relatively high rate suggests this pathway may contribute to pathogenesis of inverted urothelial neoplasms. In addition, we did not find any evidence supporting a role for HPV in the etiology of IUP.
journal_name
Hum Patholjournal_title
Human pathologyauthors
McDaniel AS,Zhai Y,Cho KR,Dhanasekaran SM,Montgomery JS,Palapattu G,Siddiqui J,Morgan T,Alva A,Weizer A,Lee CT,Chinnaiyan AM,Quist MJ,Grasso CS,Tomlins SA,Mehra Rdoi
10.1016/j.humpath.2014.06.003subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1957-65issue
9eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00240-8journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Glial tumors of the retina are rare. Most are syndrome associated and include pilocytic astrocytoma in neurofibromatosis type 1 and subependymal giant cell astrocytoma in tuberous sclerosis complex. Acquired, more conventional, diffuse astrocytomas are less frequent. Ependymoma is exquisitely rare. Herein, we report t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.06.028
更新日期：2009-04-01 00:00:00
abstract：:T3 renal cell carcinoma (RCC) is a heterogeneous group of tumors that are substaged based on perirenal or sinus fat invasion, adrenal invasion, and renal vein invasion. To evaluate whether the extent of fat invasion (minimal versus extensive) and direct adrenal gland invasion, renal vein invasion with or without concu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.04.011
更新日期：2008-11-01 00:00:00
abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.002
更新日期：2011-09-01 00:00:00
abstract：:The case of an infant with the clinical features of bronchopulmonary dysplasia but with pathologic features unlike those usually associated with this condition is reported. The condition of this infant was probably related to respiratory therapy and may have been a variant of bronchopulmonary dysplasia. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80113-1
更新日期：1985-06-01 00:00:00
abstract：:The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(96)90362-7
更新日期：1996-02-01 00:00:00
abstract：:Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20376
更新日期：2000-12-01 00:00:00
abstract：:Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowd...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90243-a
更新日期：1993-06-01 00:00:00
abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.021
更新日期：2013-08-01 00:00:00
abstract：:Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.07.019
更新日期：2020-09-01 00:00:00
abstract：:GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.05.022
更新日期：2013-11-01 00:00:00
abstract：:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.01.006
更新日期：2008-09-01 00:00:00
abstract：:Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00286-7
更新日期：2003-08-01 00:00:00
abstract：:Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleate...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80005-0
更新日期：1980-05-01 00:00:00
abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.006
更新日期：2004-01-01 00:00:00
abstract：:Endometrioid endometrial carcinomas (EECs) are correlated with high serum levels of androgens and estrogen. We hypothesized that Leydig cells and ovarian stromal hyperplasia contribute to postmenopausal ovarian androgen production and are observed more frequently in EEC patients. Ovaries of postmenopausal women with E...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.10.022
更新日期：2019-03-01 00:00:00
abstract：:Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, me...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.01.026
更新日期：2009-12-01 00:00:00
abstract：:This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(78)80005-7
更新日期：1978-01-01 00:00:00
abstract：:Combined small cell and non-small cell carcinoma is relatively rare in the lung. Examination of the clonal relationship of different components in this type of tumor may give a clue to the rarity. We retrieved 6 such tumors; all 6 had small cell carcinoma and adenocarcinoma components, and 3 had an additional squamous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/j.humpath.2003.05.001
更新日期：2003-11-01 00:00:00
abstract：:Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7636
更新日期：2000-07-01 00:00:00
abstract：:Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80467-1
更新日期：1986-04-01 00:00:00
abstract：:Loss or reduced expression of E-cadherin has been shown to be associated with poor survival in patients with bladder cancer. In numerous cases, loss of E-cadherin expression in bladder tumors has been accompanied by continued association of catenins with the membrane, suggestive of the expression of an alternative cad...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.21140
更新日期：2001-01-01 00:00:00
abstract：:Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been approved for the treatment of RCC. Combination therapy using PD-1/PD-L1 and ind...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：:Twenty-one childhood rhabdomyosarcomas were divided into three groups on the basis of cytologic composition. The tumors in group P consisted entirely of primitive mesenchymal cells, whereas those in groups M and W were characterized by the additional presence of numerous round rhabdomyoblasts and strap cells, respecti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80256-2
更新日期：1985-08-01 00:00:00
abstract：:The clinical spectrum of coronavirus disease 2019 is getting wider with the exponential increase of patients worldwide. Initially described with flu-like symptoms, variable cutaneous manifestations have been reported, with only few histopathological descriptions. Detection of the virus in cutaneous samples has been as...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80568-8
更新日期：1986-12-01 00:00:00
abstract：:Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2017.05.010
更新日期：2017-09-01 00:00:00
abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90120-6
更新日期：1993-09-01 00:00:00
abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90114-4
更新日期：1999-04-01 00:00:00
abstract：:Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.02.019
更新日期：2010-11-01 00:00:00
