Angiotropic large-cell lymphoma presenting as pulmonary small vessel occlusive disease.

Abstract:

:Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in the blood vessels or whether it represents a form of secondary intravascular dissemination of a primary solid lymphoma. The present case is unusual because death by right heart failure owing to extensive intravascular proliferation of neoplastic cells and subsequent occlusion of pulmonary blood vessels has not been described so far. In addition, the patient had suffered from a solid deposit of a large-cell B-lymphoma months before the angiotropic manifestation, suggesting that AL might develop out of more common types of non-Hodgkin's lymphomas.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Evert M,Lehringer-Polzin M,Möbius W,Pfeifer U

doi

10.1053/hupa.2000.7636

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

879-82

issue

7

eissn

0046-8177

issn

1532-8392

pii

S0046817700952432

journal_volume

31

pub_type

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