Abstract:
:A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high prevalence in AIDS patients and has occasionally been associated with other causes of immunosuppression. In previous studies, coexisting KS and thymoma were related to myasthenia gravis, corticosteroid treatment and excess CD8-positive T-lymphocyte counts. More recently an imbalance between CD4 and CD8 positive T lymphocytes has been identified in association with thymoma. The present case suggests that there may be a relationship between thymoma, CD4-positive lymphopenia, and KS.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Moysset I,Lloreta J,Miguel A,Vadell C,Ribalta T,Estrach T,Serrano Sdoi
10.1016/s0046-8177(97)90261-6subject
Has Abstractpub_date
1997-10-01 00:00:00pages
1211-3issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(97)90261-6journal_volume
28pub_type
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