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Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: an immunohistologic, ultrastructural, and cytogenetic study.

Abstract：

:Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Saw D,Chan JK,Jagirdar J,Greco MA,Lee M

doi

10.1016/0046-8177(92)90401-n

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

896-9

issue

8

eissn

0046-8177

issn

1532-8392

pii

0046-8177(92)90401-N

journal_volume

23

pub_type

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