The lymphoid system. Its normal architecture and the potential for understanding the system through the study of lymphoproliferative diseases.

abstract：:Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental abnormalities, tissue overgrowth, ...

journal_title：Human pathology

authors： Zynger DL,Gupta A,Luan C,Chou PM,Yang GY,Yang XJ

更新日期：2008-02-01 00:00:00

abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...

journal_title：Human pathology

authors： Newland JR,Linke RP,Lennert K

更新日期：1986-12-01 00:00:00

abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...

journal_title：Human pathology

authors： Huo L,Sugimura J,Tretiakova MS,Patton KT,Gupta R,Popov B,Laskin WB,Yeldandi A,Teh BT,Yang XJ

更新日期：2005-03-01 00:00:00

abstract：:Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other typ...

journal_title：Human pathology

authors： Abenoza P,Sibley RK

更新日期：1986-07-01 00:00:00

abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...

journal_title：Human pathology

authors： Berumen J,Unger ER,Casas L,Figueroa P

更新日期：1995-06-01 00:00:00

abstract：:p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...

journal_title：Human pathology

authors： Liu Y,Alqatari M,Sultan K,Ye F,Gao D,Sigel K,Zhang D,Kalir T

更新日期：2017-08-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...

journal_title：Human pathology

authors： Kowalski PJ,Paulino AF

更新日期：2002-09-01 00:00:00

abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...

journal_title：Human pathology

authors： Kaluza V,Rao DS,Said JW,de Vos S

更新日期：2006-06-01 00:00:00

abstract：:Abnormal nuclear megakaryocytic staining for phospho-STAT5 (pSTAT5) correlates with JAK2 V617F mutational status in non-chronic myelogenous leukemia chronic myeloproliferative disorders. However, a proportion of wild-type JAK2 non-chronic myelogenous leukemia chronic myeloproliferative disorders cases also demonstrate...

journal_title：Human pathology

authors： Gibson SE,Schade AE,Szpurka H,Bak B,Maciejewski JP,Hsi ED

更新日期：2008-07-01 00:00:00

abstract：:Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...

journal_title：Human pathology

authors： Yousem SA,Shaw H,Cieply K

更新日期：2001-04-01 00:00:00

abstract：:Small-cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation; however, the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in prostatic SCNC and usual-type prostatic adenocarcinoma (AdCa). We studied 32 cas...

journal_title：Human pathology

authors： Heaphy CM,Haffner MC,Graham MK,Lim D,Davis C,Corey E,Epstein JI,Eisenberger MA,Wang H,De Marzo AM,Meeker AK,Lotan TL

更新日期：2020-07-01 00:00:00

abstract：:Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...

journal_title：Human pathology

authors： Cunningham KS,Veinot JP,Feindel CM,Butany J

更新日期：2006-10-01 00:00:00

abstract：:Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...

journal_title：Human pathology

authors： He D,Manzoni A,Florentin D,Fisher W,Ding Y,Lee M,Ayala G

更新日期：2016-06-01 00:00:00

abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...

journal_title：Human pathology

authors： Wang R,Yu Z,Chen F,Liao C,Wang Q,Huang X

更新日期：2018-03-01 00:00:00

abstract：:Most ovarian sex cord-stromal tumors (SCSTs) can be categorized on the basis of conventional histology, but approximately 10% of cases are unclassified because they present indeterminate or overlapping morphologic features. Immunohistochemical and molecular studies of unclassified ovarian SCST are very limited, but re...

journal_title：Human pathology

authors： Stewart CJ,Alexiadis M,Crook ML,Fuller PJ

更新日期：2013-12-01 00:00:00

abstract：:Thromboangiitis obliterans (Buerger's disease) is an uncommon variety of occlusive peripheral vascular disease, occurring predominantly in young male tobacco smokers. The vascular lesion in the acute stage of thromboangiitis obliterans is distinctive and affects both the arteries and veins. Described here is an unusua...

journal_title：Human pathology

authors： Lie JT

更新日期：1987-04-01 00:00:00

abstract：:Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...

journal_title：Human pathology

authors： Quezado MM,Moskaluk CA,Bryant B,Mills SE,Merino MJ

更新日期：1999-02-01 00:00:00

abstract：:Papillary renal cell carcinoma (P-RCC) is the second most common type of malignant renal epithelial tumor and can be subclassified into type 1, which demonstrates simple cuboidal low-grade epithelium and type 2, which demonstrates pseudostratified high-grade epithelium with abundant eosinophilic cytoplasm. Despite thi...

journal_title：Human pathology

authors： Warrick JI,Tsodikov A,Kunju LP,Chinnaiyan AM,Palapattu GS,Morgan TM,Alva A,Tomlins S,Wu A,Montgomery JS,Hafez KS,Wolf JS Jr,Weizer AZ,Mehra R

更新日期：2014-06-01 00:00:00

abstract：:Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjace...

journal_title：Human pathology

authors： Aihara M,Truong LD,Dunn JK,Wheeler TM,Scardino PT,Thompson TC

更新日期：1994-08-01 00:00:00

abstract：:The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...

journal_title：Human pathology

authors： Madri JA,Dise CA,LiVolsi VA,Merino MJ,Bibro MC

更新日期：1981-02-01 00:00:00

abstract：:Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...

journal_title：Human pathology

authors： Kunju LP,Wojno K,Wolf JS Jr,Cheng L,Shah RB

更新日期：2008-01-01 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

更新日期：2018-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis in several malignancies but never in renal cancer. We aim to analyze the...

journal_title：Human pathology

authors： López JI,Errarte P,Erramuzpe A,Guarch R,Cortés JM,Angulo JC,Pulido R,Irazusta J,Llarena R,Larrinaga G

更新日期：2016-08-01 00:00:00

abstract：:Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...

journal_title：Human pathology

authors： Slebos RJ,Baas IO,Clement MJ,Offerhaus GJ,Askin FB,Hruban RH,Westra WH

更新日期：1998-08-01 00:00:00

abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

journal_title：Human pathology

authors： Michel RP,Limacher JJ,Kimoff RJ

更新日期：1982-01-01 00:00:00

abstract：:Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occas...

journal_title：Human pathology

authors： Matias-Guiu X,Catasus L,Bussaglia E,Lagarda H,Garcia A,Pons C,Muñoz J,Argüelles R,Machin P,Prat J

更新日期：2001-06-01 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype w...

journal_title：Human pathology

authors： Kurose N,Futatsuya C,Mizutani KI,Kumagai M,Shioya A,Guo X,Aikawa A,Nakada S,Fujimoto S,Kawabata H,Masaki Y,Takai K,Aoki S,Kojima M,Nakamura S,Yamada S

更新日期：2018-07-01 00:00:00

abstract：:Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...

journal_title：Human pathology

authors： Carson HJ,Perkins JT

更新日期：2005-01-01 00:00:00

abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...

journal_title：Human pathology

authors： Tsutsumi Y

更新日期：1989-09-01 00:00:00

abstract：:A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...

journal_title：Human pathology

authors： Dao AH,Netsky MG

更新日期：1984-05-01 00:00:00