Abstract：
:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, several other extranodal sites of involvement have been reported, including the pharynx, gastrointestinal tract, and testis. Although secondary involvement of the central nervous system has been reported, a convincing case of primary brain NK/T-cell lymphoma has not been previously reported. Here, we report a case of primary brain lymphoma of NK/T-cell type with a characteristic phenotype expressing CD3epsilon, CD56, granzyme B, Epstein-Barr virus-encoded small nuclear RNAs, with germline T-cell receptor gene configuration, and showing an unusual intravascular component. The patient underwent extensive imaging studies, revealing only the brain lesion. The lymphoma failed to respond to therapy and the patient eventually died after transfer to a hospice facility. This unusual case highlights an unusual presentation of a rare disease entity and highlights the need for a better understanding of the biology and treatment of T-cell lymphomas.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kaluza V,Rao DS,Said JW,de Vos Sdoi
10.1016/j.humpath.2006.01.032subject
Has Abstractpub_date
2006-06-01 00:00:00pages
769-72issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(06)00078-5journal_volume
37pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.002
更新日期：2009-11-01 00:00:00
abstract：:Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited. This study was carried out to evaluate the frequency of BRAF V600E ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.005
更新日期：2018-10-01 00:00:00
abstract：:Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of interest because DNA mismatch repair defects result in alterations in microsatellite stability. The current study was designed to determine w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90293-9
更新日期：1999-01-01 00:00:00
abstract：:Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80178-3
更新日期：1988-06-01 00:00:00
abstract：:CD44 is an integral membrane glycoprotein that is a principal receptor for hyaluronan and plays a role in cell-extracellular matrix interactions. Recent studies of melanomas in mouse models have suggested that increased CD44 expression by these tumors may relate to metastatic potential. Immunohistochemical expression ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90339-1
更新日期：1996-12-01 00:00:00
abstract：:Endomyocardial biopsies from right, left, or both ventricles were performed in 13 angiographically documented cases of endomyocardial fibrosis. The endocardium was appreciably thickened due to acellular hyalinized collagen tissue in all cases. Variable amounts of elastic tissue intimately admixed with fibrous tissue w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90007-6
更新日期：1990-06-01 00:00:00
abstract：:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.07.016
更新日期：2005-10-01 00:00:00
abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80164-6
更新日期：1983-10-01 00:00:00
abstract：:Langerhans' cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown etiology. We previously reported that Epstein-Barr virus (EBV) infects and proliferates in macrophages, and investigated the possibility that EBV exhibits etiologic effects in LCH. To detect EBV expression, paraffin sections from 1...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.03.017
更新日期：2004-07-01 00:00:00
abstract：:To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.05.013
更新日期：2014-09-01 00:00:00
abstract：:The case of a patient in whom idiopathic thrombocytopenic purpura (ITP) was associated with diffuse splenic histiocytosis is described; the patient's subsequent sphingomyelinase level was at the lower limits of the normal range. The patient's splenic lecithin:sphingomyelin ratio was not significantly different from th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80192-1
更新日期：1985-11-01 00:00:00
abstract：:α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.04.025
更新日期：2013-10-01 00:00:00
abstract：:Thrombosis of large fetal vessels in the placenta leads to regions of downstream avascular villi (AV). Avascular villi have been associated with adverse outcomes in anecdotal reports, but no controlled study of their significance has been done. We prospectively gathered cases of extensive AV (n = 29) occurring over a ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90118-3
更新日期：1995-01-01 00:00:00
abstract：:Small-cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation; however, the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in prostatic SCNC and usual-type prostatic adenocarcinoma (AdCa). We studied 32 cas...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.04.014
更新日期：2020-07-01 00:00:00
abstract：:Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. The aim of this study was to investigate expression of Yes-associated protein in lung adenocarcinoma and squamous cell carcinoma. Associations of Yes-associated protein express...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.08.003
更新日期：2011-03-01 00:00:00
abstract：:We used light microscopy to examine, at autopsy, bronchial arteries in three patients with cystic fibrosis who died, respectively, 10, 16, and 28 months after bronchial artery embolization with barium sulfate-impregnated polyvinyl alcohol (PVA) to control hemoptysis. PVA was not identified beyond the midsegmental bron...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80204-1
更新日期：1988-05-01 00:00:00
abstract：:There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.09.001
更新日期：2005-11-01 00:00:00
abstract：:Aberrations of the long arm of chromosome 13 are common in prostate cancer and were initially attributed to alterations of the RB1 gene in band q14 of the chromosome. However, prostate tumors generally yield normal p110RB1 nuclear staining despite loss of heterozygosity (LOH) at the RB1 locus. Our previous analysis of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90142-9
更新日期：1999-07-01 00:00:00
abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.013
更新日期：2006-05-01 00:00:00
abstract：:Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7636
更新日期：2000-07-01 00:00:00
abstract：:Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.03.007
更新日期：2010-09-01 00:00:00
abstract：:We have experienced an autopsy case of a 20-year-old woman with bronchiolitis obliterans, pemphigus vulgaris, and Castleman's disease. The affected bronchioles showed almost the same histology as previously described. But, the number of the lesions seemed too small to cause her death of respiratory insufficiency. We a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90208-2
更新日期：1997-11-01 00:00:00
abstract：:Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90267-k
更新日期：1993-12-01 00:00:00
abstract：:Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.03.004
更新日期：2008-10-01 00:00:00
abstract：:The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90035-f
更新日期：1993-03-01 00:00:00
abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.6276
更新日期：2000-09-01 00:00:00
abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：:Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.006
更新日期：2013-10-01 00:00:00
abstract：:Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90084-1
更新日期：1994-12-01 00:00:00
abstract：:The pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80012-6
更新日期：1987-03-01 00:00:00
