Splenic histiocytosis in idiopathic thrombocytopenic purpura: a relative sphingomyelinase deficiency?

abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...

journal_title：Human pathology

authors： Prat J

更新日期：2004-06-01 00:00:00

abstract：:This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...

journal_title：Human pathology

authors： Wu Y,Wang T,Ye S,Zhao R,Bai X,Wu Y,Abe K,Jin X

更新日期：2012-01-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Human pathology

authors： Genta RM

更新日期：2011-04-17 00:00:00

abstract：:Endomyocardial biopsies from right, left, or both ventricles were performed in 13 angiographically documented cases of endomyocardial fibrosis. The endocardium was appreciably thickened due to acellular hyalinized collagen tissue in all cases. Variable amounts of elastic tissue intimately admixed with fibrous tissue w...

journal_title：Human pathology

authors： Chopra P,Narula J,Talwar KK,Kumar V,Bhatia ML

更新日期：1990-06-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prev...

journal_title：Human pathology

authors： Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido S

更新日期：2006-04-01 00:00:00

abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...

journal_title：Human pathology

authors： Uchida K,Ross H,Lotan T,Pignon JC,Signoretti S,Epstein JI,Illei PB

更新日期：2015-03-01 00:00:00

abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...

journal_title：Human pathology

authors： Carney JA,Lyssikatos C,Lodish MB,Stratakis CA

更新日期：2015-01-01 00:00:00

abstract：:To investigate the relationship between the tissue distribution and the types of amyloid proteins, the detailed histopathologic features of the available liver in 284 cases of amyloidosis were examined. We classified hepatic amyloidosis into three types, namely, the vascular pattern, parenchymal pattern, and stromal p...

journal_title：Human pathology

authors： Iwata T,Hoshii Y,Kawano H,Gondo T,Takahashi M,Ishihara T,Yokota T,Ueda J,Uchino F

更新日期：1995-10-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...

journal_title：Human pathology

authors： Nohr E,Girard L,James M,Benediktsson H

更新日期：2014-07-01 00:00:00

abstract：:We studied c-erbB-2, p53, and nm23 gene products in 112 primary breast carcinomas. Fifty patients were aged 35 years or younger, and 62 were aged 36 to 50. Clinicopathological criteria including clinical stage, hormone receptor status, histological types, histological grades, and lymph node status, were reviewed. Dise...

journal_title：Human pathology

authors： Bertheau P,Steinberg SM,Merino MJ

更新日期：1998-04-01 00:00:00

abstract：:There is considerable interest in the role of the human wart virus in the pathogenesis of squamous cell carcinoma. Mucosal wart virus infections may produce considerable epithelial atypia and have eventuated in carcinoma in "normal" individuals in some instances. The verruciform lesions of patients with epidermodyspla...

journal_title：Human pathology

authors： Gisser SD

更新日期：1981-02-01 00:00:00

abstract：:Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....

journal_title：Human pathology

authors： Evans HL,Burks E,Viswanatha D,Larson RS

更新日期：2000-10-01 00:00:00

abstract：:Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, me...

journal_title：Human pathology

authors： Schmitz KJ,Lang H,Kaiser G,Wohlschlaeger J,Sotiropoulos GC,Baba HA,Jasani B,Schmid KW

更新日期：2009-12-01 00:00:00

abstract：:Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...

journal_title：Human pathology

authors： Chakraborty J,Franco-Saenz R,Kropp K

更新日期：1983-02-01 00:00:00

abstract：:The case of a biliary cystadenoma containing foci of cystadenocarcinoma is reported, along with the first electron microscopic description of this lesion. Both neoplastic and congenital origins have been implicated in the pathogenesis of biliary cystadenomas. In this case hamartomatous bile ducts were found, supportin...

journal_title：Human pathology

authors： Devine P,Ucci AA

更新日期：1985-01-01 00:00:00

abstract：:Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...

journal_title：Human pathology

authors： Flint A,Weiss SW

更新日期：1995-04-01 00:00:00

abstract：:Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...

journal_title：Human pathology

authors： Kleinschmidt-Demasters BK,Evans LC,Bobak JB,Lopez-Uribe D,Hopper D,Shroyer AL,Shroyer KR

更新日期：2000-08-01 00:00:00

abstract：:As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...

journal_title：Human pathology

authors： Xu Y,Yu W,Yang T,Zhang M,Liang C,Cai X,Shao Q

更新日期：2018-05-01 00:00:00

abstract：:The ontogeny and distribution of the epidermal growth factor (EGF) receptor and lipocortin-1, a major cellular substrate of the EGF receptor, were evaluated in a developmental series of fetal and neonatal human lungs (8 to 41 weeks' gestation and stillborn to 16 days' postnatal age). The peroxidase anti-peroxidase tec...

journal_title：Human pathology

authors： Johnson MD,Gray ME,Carpenter G,Pepinsky RB,Stahlman MT

更新日期：1990-02-01 00:00:00

abstract：:A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...

journal_title：Human pathology

authors： Abdul-Karim FW,Lederman MM,Carter JR,Hewlett EL,Newman AJ,Greene BM

更新日期：1981-01-01 00:00:00

abstract：:Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...

journal_title：Human pathology

authors： Annan AC,Stevens KA,Osunkoya AO

更新日期：2017-07-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...

journal_title：Human pathology

authors： Miettinen M,Sarlomo-Rikala M,Lasota J

更新日期：1999-10-01 00:00:00

abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...

journal_title：Human pathology

authors： Park JH,Lee C,Suh JH,Chae JY,Kim HW,Moon KC

更新日期：2015-03-01 00:00:00

abstract：:Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...

journal_title：Human pathology

authors： Stalsberg H,Hartmann WH

更新日期：2000-05-01 00:00:00

abstract：:A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...

journal_title：Human pathology

authors： Shannon BA,Cohen RJ,Segal A,Baker EG,Murch AR

更新日期：2009-03-01 00:00:00

abstract：:Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...

journal_title：Human pathology

authors： Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto M

更新日期：2013-09-01 00:00:00

abstract：:Galectins, a family of beta-galactoside-binding animal lectins, might be involved in tumor progression. In this study, the expression patterns of galectin-1 and -3 were examined immunohistochemically in intrahepatic cholangiocarcinoma (ICC), with emphasis on its development and progression as well as its histopatholog...

journal_title：Human pathology

authors： Shimonishi T,Miyazaki K,Kono N,Sabit H,Tuneyama K,Harada K,Hirabayashi J,Kasai K,Nakanuma Y

更新日期：2001-03-01 00:00:00

abstract：:RBM (RNA-binding motif) protein is a marker of male germ cells. This protein is encoded by the Azoospermia factor region-b (AZF-b) of the human Y chromosome and is expressed exclusively in the male germ cell line, that is, spermatogonia, spermatocytes, and round spermatids. The authors analyzed the expression of the R...

journal_title：Human pathology

authors： Lifschitz-Mercer B,Elliott DJ,Leider-Trejo L,Schreiber-Bramante L,Hassner A,Eisenthal A,Maymon BB

更新日期：2000-09-01 00:00:00

abstract：:The expression of the proteins encoded by the ras, myc, and erb B-2 oncogenes was examined in 63 paraffin-embedded human cholangiocarcinomas of Thai and English origin using immunohistochemistry. The observed distributions were compared with oncogene expression in a series of human hepatocellular carcinomas. In an att...

journal_title：Human pathology

authors： Voravud N,Foster CS,Gilbertson JA,Sikora K,Waxman J

更新日期：1989-12-01 00:00:00

abstract：:The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin...

journal_title：Human pathology

authors： Gaines JJ Jr,Tom GD,Khankhanian N

更新日期：1987-11-01 00:00:00