Abstract:
:To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were classified according to histomorphology and location of neoplasms, and we evaluated the characteristics of each classified group using complementary immunohistochemical procedures. The CK20-positive rates of each location type were also evaluated. Subjects presented with 52 intestinal-type adenomas (low/high grade, 32:20) and 4 noninvasive pancreatobiliary papillary neoplasms (low/high grade, 1:3). Twenty-seven periampullary (peri-AMP)-type tumors and 23 extended-type tumors comprised the intestinal type, and the intra-ampullary (intra-AMP) type was composed of 4 pancreatobiliary and 2 intestinal histomorphological types. The CK20-positive rates of these 3 location types differed significantly (peri-AMP type, 50.6% ± 21.0%; extended type, 35.4% ± 18.6%; intra-AMP type, 6.9% ± 6.3%). The CK20-positive rate for intestinal-type tumors of the intra-AMP location type was lower than that of the peri-AMP location type. Intestinal-type tumors without CDX2 expression included extended and intra-AMP types, which are tumors that may show positive vertical margins when EP is performed. In this study, we found that an understanding of pancreatobiliary-type histology is an important aspect for the investigation of tumors involving the common channel of the ampulla. Furthermore, immunostaining of CDX2 and CK20 provides beneficial information if considering whether to perform an EP.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Yamamoto Y,Nemoto T,Okubo Y,Nihonyanagi Y,Ishiwatari T,Takuma K,Tochigi N,Okano N,Wakayama M,Igarashi Y,Shibuya Kdoi
10.1016/j.humpath.2014.05.013subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1910-7issue
9eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00233-0journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90124-7
更新日期:1999-04-01 00:00:00
abstract::Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.05.007
更新日期:2019-08-01 00:00:00
abstract::Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both tumors share similar histologic features and have overlapping immunohistochemical profile. We compared the expression of adipophilin, cytokeratin 5/6, p63, GATA3, mammag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.09.007
更新日期:2014-02-01 00:00:00
abstract::Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(03)00121-7
更新日期:2003-05-01 00:00:00
abstract::Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.12.003
更新日期:2010-06-01 00:00:00
abstract::A 64-year-old man with pseudosarcoma of the esophagus is described. Morphologic examinations of this rare tumor were made, and the origin of the sarcoma-like cells of the tumor is discussed. The findings for the sarcoma-like cells of the tumor support the idea that the sarcoma-like elements arose through transformatio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80036-1
更新日期:1982-05-01 00:00:00
abstract::Analogous to mixed tumors of salivary glands (" pleomorphic adenomas" ), cutaneous mixed tumors (" chondroid syringomas" ) contain a ductal (epithelial) component and a variably prominent myoepithelial component. Tumors showing purely myoepithelial differentiation (myoepitheliomas) have only recently been recognized t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.08.016
更新日期:2004-01-01 00:00:00
abstract::Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.03.011
更新日期:2004-08-01 00:00:00
abstract::High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90004-3
更新日期:1994-09-01 00:00:00
abstract::Oral cancer overexpressed 1 (ORAOV1) has been reported to exhibit high amplification levels in esophageal squamous cell cancer (ESCC) and in premalignant lesions. However, ORAOV1 protein expression levels in ESCC and esophageal squamous intraepithelial neoplasia (ESIN) have not yet been reported. We have explored the ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.009
更新日期:2015-05-01 00:00:00
abstract::Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of the platelet surface and the membranes enclosing storage organelles. It is not surprising, therefore, that membrane defects are common in platelets from patients with inherited h...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(87)80331-3
更新日期:1987-02-01 00:00:00
abstract::The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(76)80040-8
更新日期:1976-05-01 00:00:00
abstract::The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.025
更新日期:2011-02-01 00:00:00
abstract::Kearns-Sayre syndrome (KSS) and Pearson's marrow-pancreas syndrome (PMPS) are rare disorders caused by the same molecular defect, one of several deletion mutations in mitochondrial DNA (mtDNA). KSS is an encephalomyopathy with ophthalmoplegia, retinal degeneration, ataxia, and endocrine abnormalities. PMPS is a disord...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90204-6
更新日期:1999-05-01 00:00:00
abstract::The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.06.033
更新日期:2018-12-01 00:00:00
abstract::Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90232-r
更新日期:1992-02-01 00:00:00
abstract::Deposits found intrauterine contraceptive devices (IUDs) were studied by scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray microanalysis. All seven devices, including five plastic and two copper IUDs, were coated with a crust containing cellular, acellular, and fibrillar material. The cellul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80160-x
更新日期:1985-07-01 00:00:00
abstract::GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.014
更新日期:2010-07-01 00:00:00
abstract::The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(96)90362-7
更新日期:1996-02-01 00:00:00
abstract::Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90145-7
更新日期:1994-04-01 00:00:00
abstract::Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor. Immunophenotypical evidence suggests it is of synovial cell origin. There is controversy regarding the underlying nature of this lesion, specifically whether it is a neoplastic or nonneoplastic (ie, reactive or hyperplastic) process. Karyotypic a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90155-6
更新日期:1997-07-01 00:00:00
abstract::A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2020.03.007
更新日期:2020-05-01 00:00:00
abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90215-3
更新日期:1993-11-01 00:00:00
abstract::Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.002
更新日期:2007-04-01 00:00:00
abstract::The use of interleukin-2 (IL-2), either alone or in combination with lymphokine-activated killer cells, tumor infiltrating lymphocytes, or other immunotherapeutic agents has added a new list of alternatives to conventional antineoplastic regimens. Little information is available about the pathologic changes occurring ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90005-p
更新日期:1990-05-01 00:00:00
abstract::Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90015-9
更新日期:1994-09-01 00:00:00
abstract::After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.07.037
更新日期:2013-12-01 00:00:00
abstract::Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hp.2000.6699
更新日期:2000-05-01 00:00:00
abstract::Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but und...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.027
更新日期:2012-10-01 00:00:00
abstract::Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal ant...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80235-1
更新日期:1988-12-01 00:00:00