Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer.

abstract：:Invasive mammary carcinoma with neuroendocrine differentiation has been controversial in terms of its definition and clinical outcome. In 2003, the World Health Organization histologic classification of tumors designated this entity as neuroendocrine carcinoma of the breast and defined mammary neuroendocrine carcinoma...

journal_title：Human pathology

authors： Tian Z,Wei B,Tang F,Wei W,Gilcrease MZ,Huo L,Albarracin CT,Resetkova E,Middleton L,Sahin A,Xing Y,Hunt KK,Chen J,Bu H,Rashid A,Abraham SC,Wu Y

更新日期：2011-08-01 00:00:00

abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...

journal_title：Human pathology

authors： Khettry U,Anand N,Gordon FD,Jenkins RL,Tahan SR,Loda M,Lewis WD

更新日期：2000-01-01 00:00:00

abstract：:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and d...

journal_title：Human pathology

authors： Kamel OW,Horoupian DS,Silverberg GD

更新日期：1989-12-01 00:00:00

abstract：:The histologic findings in lymph nodes were used to identify eight patients, who are not in a high-risk group, with human immunodeficiency virus (HIV) infection. In order to determine the specificity of these findings, the histologic and clinical findings in these patients were compared with the histologic and clinica...

journal_title：Human pathology

authors： Butler JJ,Osborne BM

更新日期：1988-07-01 00:00:00

abstract：:We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...

journal_title：Human pathology

authors： Kobayashi M,Ooi A,Oda Y,Nakanishi I

更新日期：2002-01-01 00:00:00

abstract：:Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occas...

journal_title：Human pathology

authors： Matias-Guiu X,Catasus L,Bussaglia E,Lagarda H,Garcia A,Pons C,Muñoz J,Argüelles R,Machin P,Prat J

更新日期：2001-06-01 00:00:00

abstract：:Congenital cystic adenomatoid malformation (CCAM) of the lung is a congenital lesion that is sometimes complicated by bronchioloalveolar adenocarcinoma (BAC). In some cases foci of atypical goblet cell hyperplasia (AGCH) can be found within the cysts. It has been proposed that CCAM and AGCH predispose to the developme...

journal_title：Human pathology

authors： Stacher E,Ullmann R,Halbwedl I,Gogg-Kammerer M,Boccon-Gibod L,Nicholson AG,Sheppard MN,Carvalho L,Franca MT,Macsweeney F,Morresi-Hauf A,Popper HH

更新日期：2004-05-01 00:00:00

abstract：:Diffuse gastric cancer, characterized by poorly cohesive, diffusely infiltrating cells with no or little gland formation, is known to show several morphologic variants, but their prognostic value, if any, is poorly documented. In this article, 119 cases of invasive (T1b to T4) diffuse gastric cancer, which had undergo...

journal_title：Human pathology

authors： Chiaravalli AM,Klersy C,Tava F,Manca R,Fiocca R,Capella C,Solcia E

更新日期：2009-11-01 00:00:00

abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...

journal_title：Human pathology

authors： MacQuarrie E,Arnason T,Gruchy J,Yan S,Drucker A,Huang WY

更新日期：2012-08-01 00:00:00

abstract：:Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...

journal_title：Human pathology

authors： Azmahani A,Nakamura Y,Ozawa Y,McNamara KM,Fujimura T,Haga T,Hashimoto A,Aiba S,Sasano H

更新日期：2015-11-01 00:00:00

abstract：:Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...

journal_title：Human pathology

authors： Clemente C,Cochran AJ,Elder DE,Levene A,MacKie RM,Mihm MC,Rilke F,Cascinelli N,Fitzpatrick TB,Sober AJ

更新日期：1991-04-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many tumors, but data for primary neuroendocrine carcinoma (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prog...

journal_title：Human pathology

authors： Massi D,Franchi A,Ketabchi S,Paglierani M,Pimpinelli N,Santucci M

更新日期：2003-01-01 00:00:00

abstract：:There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...

journal_title：Human pathology

authors： Singh K,Wang Y,Marketkar S,Kalife ET,Steinhoff MM

更新日期：2017-07-01 00:00:00

abstract：:We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...

journal_title：Human pathology

authors： Knowles DM,Wolff M

更新日期：1976-09-01 00:00:00

abstract：:The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...

journal_title：Human pathology

authors： Oliveira Carneiro FR,da Cunha Fischer TR,Brandão CM,Pagliari C,Duarte MI,Quaresma JA

更新日期：2015-02-01 00:00:00

abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...

journal_title：Human pathology

authors： Canet B,Pons C,Espinosa I,Prat J

更新日期：2012-05-01 00:00:00

abstract：:Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...

journal_title：Human pathology

authors： George TI,Jones CD,Zehnder JL,Warnke RA,Dorfman RF

更新日期：2003-02-01 00:00:00

abstract：:Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...

journal_title：Human pathology

authors： Quezado MM,Moskaluk CA,Bryant B,Mills SE,Merino MJ

更新日期：1999-02-01 00:00:00

abstract：:The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...

journal_title：Human pathology

authors： Nishimura S,Tsuda H,Kataoka F,Arao T,Nomura H,Chiyoda T,Susumu N,Nishio K,Aoki D

更新日期：2011-04-01 00:00:00

abstract：:Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...

journal_title：Human pathology

authors： Yamamoto H,Kojima A,Miyasaka Y,Imamura M,Nakamura N,Yao T,Tsuneyoshi M,Oda Y

更新日期：2010-10-01 00:00:00

abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...

journal_title：Human pathology

authors： Jaso J,Chen L,Li S,Lin P,Chen W,Miranda RN,Konoplev S,Medeiros LJ,Yin CC

更新日期：2012-09-01 00:00:00

abstract：:The SHH signaling pathway is critical for gastrointestinal development and organic patterning, and dysregulation of SHH pathway molecules has been detected in multiple gastrointestinal neoplasms. This study investigated the role of the SHH signaling pathway in PJS. Expression of SHH, PTCH, and GLI1 was examined by rea...

journal_title：Human pathology

authors： Xu X,Su J,Li R,Wang Y,Zeng D,Wu B

更新日期：2016-04-01 00:00:00

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:In a recent evaluation by comparative genomic hybridization, we demonstrated chromosome 14q31-32.1 to be frequently deleted in adenocarcinomas of the gastroesophageal junction. This suggests the presence of a tumor suppressor gene in the deleted region. In the present study, we have performed a detailed loss of hetero...

journal_title：Human pathology

authors： Dinjens WN,Koppert LB,Dezentjé DA,Abbou M,van Ballegooijen ES,Sleddens HF,van Dekken H,Tilanus HW,Wijnhoven BP

更新日期：2006-05-01 00:00:00

abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...

journal_title：Human pathology

authors： Schwarz J,Ayim A,Schmidt A,Jäger S,Koch S,Baumann R,Dünne AA,Moll R

更新日期：2006-05-01 00:00:00

abstract：:Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...

journal_title：Human pathology

authors： Haas M

更新日期：2003-01-01 00:00:00

abstract：:The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysp...

journal_title：Human pathology

authors： Pascal RR

更新日期：1994-11-01 00:00:00

abstract：:The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...

journal_title：Human pathology

authors： Fine G,Raju U

更新日期：1987-08-01 00:00:00

abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...

journal_title：Human pathology

authors： Hervieu V,Christa L,Gouysse G,Bouvier R,Chayvialle JA,Bréchot C,Scoazec JY

更新日期：2006-08-01 00:00:00

abstract：:Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...

journal_title：Human pathology

authors： Kumashiro Y,Yao T,Aishima S,Hirahashi M,Nishiyama K,Yamada T,Takayanagi R,Tsuneyoshi M

更新日期：2007-06-01 00:00:00