Androgen receptor, androgen-producing enzymes and their transcription factors in extramammary Paget disease.

Abstract:

:Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen production in androgen-responsive tissues including androgen-dependent neoplasms. Therefore, in this study, we immunolocalized AR, androgen-producing enzymes, and their transcription factors to assess the state of in situ androgen production and actions and its correlation of invasiveness in EMPD. We studied 51 cases of EMPD with known clinicopathological status. AR, 5α-red1, 17β-HSD5, and β-catenin immunoreactivity was evaluated by using the modified H-score method while cyclin D1, p53, forkhead box protein P1, and a proliferation marker, Ki-67, were quantified using labeling index. The mean scores of AR, 5α-red1, and 17β-HSD5 in invasive EMPD were all significantly higher than noninvasive EMPD (P < .0001). Ki-67 labeling index as well as the cyclin D1 score was also significantly higher in invasive than noninvasive lesions of EMPD. These results demonstrated that androgen receptor and androgen-producing enzymes were both associated with cell cycle regulation and subsequently the invasiveness of EMPD lesions and could also indicate those above as potential markers of invasive potentials in EMPD.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Azmahani A,Nakamura Y,Ozawa Y,McNamara KM,Fujimura T,Haga T,Hashimoto A,Aiba S,Sasano H

doi

10.1016/j.humpath.2015.07.007

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1662-9

issue

11

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(15)00252-X

journal_volume

46

pub_type

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