Abstract：
:The SHH signaling pathway is critical for gastrointestinal development and organic patterning, and dysregulation of SHH pathway molecules has been detected in multiple gastrointestinal neoplasms. This study investigated the role of the SHH signaling pathway in PJS. Expression of SHH, PTCH, and GLI1 was examined by real-time PCR and immunohistochemistry in 20 normal tissues and 75 colorectal lesions (25 PJPs, 25 adenomas, and 25 adenocarcinomas). Expression of SHH, PTCH, and GLI1 mRNA was higher in PJPs than in normal tissue (P < .05) and gradually increased along the PJP-adenoma-adenocarcinoma sequence (P < .05). Immunostaining indicated that SHH expression was present in 60% of PJPs, 72% of adenomas, and 84% of carcinomas, whereas 68% of PJPs, 72% of adenomas, and 88% of carcinomas exhibited cytoplasmic expression of PTCH. Moreover, high GLI1 expression was detected in 56% of PJPs, 64% of adenomas, and 80% of carcinomas; and high nuclear expression of GLI1 was observed in 8 adenomas with atypia and 15 carcinomas. Increased SHH, PTCH, and GLI1 protein correlated positively with tumor grade (P = .012, P = .003, and P = .007, respectively), tumor depth (P = .024, P = .007, and P = .01), and lymph node metastasis (P = .05, P = .015, and P = .005). This study identified aberrant expression of SHH pathway molecules in PJS, and the findings may supply a novel mechanism for the development of PJ polyps.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Xu X,Su J,Li R,Wang Y,Zeng D,Wu Bdoi
10.1016/j.humpath.2015.09.044subject
Has Abstractpub_date
2016-04-01 00:00:00pages
153-61eissn
0046-8177issn
1532-8392pii
S0046-8177(15)00498-0journal_volume
50pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90125-6
更新日期：1995-01-01 00:00:00
abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90432-4
更新日期：1998-10-01 00:00:00
abstract：:Fibrillar proteins with a role in cellular shape and motility are present in the cytoplasm of most animal cells. They vary greatly in size, organization, and reactivity according to cell type and can be separately identified by the use of recently developed monospecific antisera and indirect immunofluorescence stainin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80026-3
更新日期：1981-05-01 00:00:00
abstract：:The clinical spectrum of coronavirus disease 2019 is getting wider with the exponential increase of patients worldwide. Initially described with flu-like symptoms, variable cutaneous manifestations have been reported, with only few histopathological descriptions. Detection of the virus in cutaneous samples has been as...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：:Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90162-a
更新日期：1993-05-01 00:00:00
abstract：:Tissues obtained from 600 routine autopsies were studied. Mineral oil lipidosis was present in the spleen (76 per cent), liver (45 per cent), bone marrow (26 per cent), and lymph nodes; more than 50 per cent of the lymph nodes from the mesentery, porta hepatis, and mediastinum were affected. Mineral oil and its metabo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80163-x
更新日期：1984-08-01 00:00:00
abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.032
更新日期：2006-06-01 00:00:00
abstract：:Fluorescence in situ hybridization, loss of heterozygosity testing, and comparative genomic hybridization have been used to detect NF2 gene alterations in both sporadic and neurofibromatosis type 2 (NF2)-associated central nervous system tumors. In this study, we performed chromogenic in situ hybridization (CISH) and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.027
更新日期：2007-09-01 00:00:00
abstract：:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.10.008
更新日期：2015-01-01 00:00:00
abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.01.003
更新日期：2018-04-01 00:00:00
abstract：:In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.04.010
更新日期：2016-09-01 00:00:00
abstract：:Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.007
更新日期：2020-12-01 00:00:00
abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.030
更新日期：2007-11-01 00:00:00
abstract：:We studied renal tissues from 203 patients with acquired immunodeficiency syndrome (AIDS). Of the 203 patients, 20 showed light-microscopic changes characteristic of AIDS-associated nephropathy (AAN). Fifteen of the 20 (group A) were examined by immunohistochemistry using Mycoplasma fermentans (incognitus strain)-spec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90063-u
更新日期：1991-01-01 00:00:00
abstract：:In a recent evaluation by comparative genomic hybridization, we demonstrated chromosome 14q31-32.1 to be frequently deleted in adenocarcinomas of the gastroesophageal junction. This suggests the presence of a tumor suppressor gene in the deleted region. In the present study, we have performed a detailed loss of hetero...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.12.010
更新日期：2006-05-01 00:00:00
abstract：:All cases of primary breast carcinoma seen at the George Washington University Medical Center between 1971 and 1975 and between 1981 and 1986 were reviewed, and examples of pure and mixed infiltrating cribriform carcinoma (ICC) were identified. The relative frequency of ICC did not change significantly from the earlie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90235-w
更新日期：1990-03-01 00:00:00
abstract：:The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(76)80040-8
更新日期：1976-05-01 00:00:00
abstract：:Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.07.019
更新日期：2020-09-01 00:00:00
abstract：:Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.02.007
更新日期：2009-08-01 00:00:00
abstract：:Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.010
更新日期：2004-10-01 00:00:00
abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.006
更新日期：2004-01-01 00:00:00
abstract：:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2003.62
更新日期：2003-04-01 00:00:00
abstract：:Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90175-5
更新日期：1989-02-01 00:00:00
abstract：:The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document....
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2014.07.008
更新日期：2014-11-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.009
更新日期：2006-09-01 00:00:00
abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90017-8
更新日期：1989-05-01 00:00:00
abstract：:Congenital subclavian steal may result from various anomalies of the aortic arch. The most common predisposing type is the right aortic arch with an isolated left subclavian artery arising from a left ductus arteriosus. A rare variant includes isolation of the left common carotid as well as the left subclavian arterie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80200-6
更新日期：1981-10-01 00:00:00
abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.011
更新日期：2015-03-01 00:00:00
abstract：:Dermatofibrosarcoma protuberans is genetically characterized by the translocation t(17;22)(q22;q13) resulting in the PDGFB/COL1A1 fusion gene. Fluorescence in situ hybridization with specific probes enables a rapid detection of this gene. In this study, the presence of the translocation t(17;22)(q22;q13) by fluorescen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.07.015
更新日期：2011-02-01 00:00:00
