Abstract：
:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and disclosed focal presence of growth hormone and prolactin-secreting cells in the adenoma. Ultrastructurally, some of the larger ganglion cells contained (and were often filled with) zebra-like bodies, while the adenoma was shown to be sparsely granulated with numerous fibrous bodies. These findings support the term of mixed gangliocytoma-adenoma for these rare intrasellar tumors and provide additional support for their nature as independent neuroendocrine units.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kamel OW,Horoupian DS,Silverberg GDdoi
10.1016/s0046-8177(89)80012-7subject
Has Abstractpub_date
1989-12-01 00:00:00pages
1198-203issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(89)80012-7journal_volume
20pub_type
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