Abstract:
:The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting both cellular proto-oncogenes and tumor suppressor genes are involved during the development and progression of both esophageal and gastric cancers. The different histological forms of both esophageal and gastric carcinomas as well as their differing etiologies result in the possibility that a spectrum of genetic changes is involved in different tumor types. p53 abnormalities occur frequently in tumors arising in both organs, and in both sites p53 abnormalities can be observed in precancerous lesions as well as in overt cancer. Subsequent abnormalities affecting other genes (eg, epithelial growth factor receptors [EGFRs]) potentially enhance the growth potential of tumors. This review focuses on abnormalities of oncogenes, tumor suppressor genes, and growth factors commonly found in cancers of the esophagus and stomach.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Stemmermann G,Heffelfinger SC,Noffsinger A,Hui YZ,Miller MA,Fenoglio-Preiser CMdoi
10.1016/0046-8177(94)90056-6subject
Has Abstractpub_date
1994-10-01 00:00:00pages
968-81issue
10eissn
0046-8177issn
1532-8392pii
0046-8177(94)90056-6journal_volume
25pub_type
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