Abstract:
:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lymphatic vessels remains to be further investigated. Lymphatic vessel density, lymphatic invasion, the expression of hepatocyte growth factor, c-Met, and vascular endothelial growth factor C proteins were evaluated by immunohistochemistry in 76 cases of oral squamous cell carcinoma. The distribution of c-Met on lymphatic endothelium was examined. High expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = .045), high expression of vascular endothelial growth factor-C (P < .001), higher peritumoral lymphatic vessel density (P = .003), higher incidence of peritumoral lymphatic invasion (P = .032), and positive lymph node status (P = .005), in spite of its negative expression on most lymphatic vessels. Patients with high-c-Met expression tumors exhibited shorter overall survival and disease-free survival (P < .001 and P = .010, respectively). Taken together, our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic factor, vascular endothelial growth factor C, and, by extension, with lymphangiogenesis and lymph node metastasis, suggesting important prognostic significance of c-Met for patients with oral squamous cell carcinoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Zhao D,Wang SH,Feng Y,Hua CG,Zhao J,Tang XFdoi
10.1016/j.humpath.2010.03.012subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1514-23issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(11)00055-4journal_volume
42pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90231-3
更新日期:1998-02-01 00:00:00
abstract::To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80005-6
更新日期:1976-01-01 00:00:00
abstract::Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.19298
更新日期:2000-10-01 00:00:00
abstract::Three cases of giant cell carcinoma of lung and six other lung carcinomas with large atypical cell formation were studied by both light and electron microscopy. The giant cell carcinomas showed unique light and electron microscopic features, whereas large atypical cells from other lung carcinomas usually retained some...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80003-2
更新日期:1976-01-01 00:00:00
abstract::An increase in S100 protein-positive cells has been reported in inflammatory bowel diseases, mainly Crohn disease. These cells were interpreted as myeloid-derived dendritic cells, chiefly in follicular areas. We were prompted to assess the nature of these cells in interfollicular areas of inflamed colonic mucosa in ul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.11.017
更新日期:2009-08-01 00:00:00
abstract::Cellular crescents are typically inflammatory and associated with rapidly progressive glomerulonephritis. Their pathogenesis involves glomerular basement membrane rupture due to circulating or intrinsic factors. Crescents associated with diabetic glomerulosclerosis are rarely reported. Furthermore, the nature of cells...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.030
更新日期:2014-03-01 00:00:00
abstract::The pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80012-6
更新日期:1987-03-01 00:00:00
abstract::Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80375-1
更新日期:1987-11-01 00:00:00
abstract::Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.019
更新日期:2015-05-01 00:00:00
abstract::The diagnosis of placental site trophoblastic lesions, particularly the distinction of a placental site trophoblastic tumor from an exaggerated placental site, can be difficult. Mel-CAM (also known as CD146 and MUC18) is a recently recognized cell adhesion molecule belonging to the immunoglobin gene superfamily that s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90386-0
更新日期:1998-01-01 00:00:00
abstract::Five hundred eighty renal biopsies from a pool of 27850 archived cases were identified in which a myoglobin stain was performed because of atypical casts. Two hundred and thirty-eight (41%) of these biopsies were found to be positive for myoglobin casts. The morphology of the myoglobin casts ranged from light, almost ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.02.026
更新日期:2016-08-01 00:00:00
abstract::Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.02.009
更新日期:2017-07-01 00:00:00
abstract::Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.07.012
更新日期:2013-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an angiogenic factor that plays important roles in tumor growth. Angiogenesis studies on VEGF deal with various types of malignant tumors, but very little is known about the role or significance of VEGF in human thyroid neo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90241-1
更新日期:1999-08-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.05.028
更新日期:2014-01-01 00:00:00
abstract::The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80385-4
更新日期:1987-11-01 00:00:00
abstract::Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90411-u
更新日期:1992-08-01 00:00:00
abstract::Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.03.011
更新日期:2004-08-01 00:00:00
abstract::Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas an...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)80009-9
更新日期:1998-06-01 00:00:00
abstract::Alterations in the Notch signaling pathway play a role in colorectal cancer (CRC). Hes1, a Notch-induced transcription factor, has recently been reported to show decreased expression by immunohistochemistry in sessile serrated adenomas. Variable staining patterns have been reported in tubular adenomas, and existing da...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.010
更新日期:2016-11-01 00:00:00
abstract::This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90145-8
更新日期:1996-01-01 00:00:00
abstract::Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.011
更新日期:2019-01-01 00:00:00
abstract::This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(78)80005-7
更新日期:1978-01-01 00:00:00
abstract::Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer; however, clinicopathological featur...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.05.009
更新日期:2018-09-01 00:00:00
abstract::Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80132-4
更新日期:1978-09-01 00:00:00
abstract::The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80080-9
更新日期:1981-09-01 00:00:00
abstract::Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated pro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.01.010
更新日期:2017-07-01 00:00:00
abstract::Xanthoma is a localized collection of cholesterol-laden histiocytes that is usually idiopathic, but may be seen in patients with hyperlipidemia. We report seven cases of xanthoma involving the prostate, including one arising in a patient with mild hyperlipidemia. Prostatic xanthoma appeared as a solitary microscopic l...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90147-3
更新日期:1994-04-01 00:00:00
abstract::This report concerns a young woman who, after taking a contraceptive preparation orally for three years, developed the Budd-Chiari syndrome as the result of a widespread chronic obliterative process involving the intrahepatic efferent venous system. Her prolonged course, which failed to respond to an end-to-side porta...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80082-2
更新日期:1976-11-01 00:00:00
abstract::Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.002
更新日期:2007-01-01 00:00:00