Nesidiodysplasia--a histologic entity?


:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta cells in PNHH cases, in comparison with age-matched control cases. A smaller increase (9%) was found in nuclear area and absorbance of non-endocrine ductal cells in PNHH cases. In all PNHH and control cases, higher values of nuclear area and absorbance were found for beta cells in the islets of Langerhans than for nesidioblasts. The increase in average size of beta cell nuclei in PNHH can be used as a morphologic criterion for diagnosis in these cases. The increased absorbance of the nuclei stained with the Feulgen reaction is the morphologic expression of polyploidy, and has a correlation to the metabolic activity of beta cells in this disorder. We conclude that, in contrast to the normal postnatal developmental process of nesidioblastosis, nesidiodysplasia is a well-defined histologic entity, manifested by an increase of beta cell nuclear size and its DNA content.


Hum Pathol


Human pathology


Ariel I,Kerem E,Schwartz-Arad D,Bartfeld E,Ron N,Pizov G,Zajicek G




Has Abstract


1988-10-01 00:00:00














  • Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma.

    abstract::Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Pierson CR,Schober MS,Wallis T,Sarkar FH,Sorensen PH,Eble JN,Srigley JR,Jones EC,Grignon DJ,Adsay V

    更新日期:2001-05-01 00:00:00

  • Mallory bodies in scar adenocarcinoma of the lung.

    abstract::A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Michel RP,Limacher JJ,Kimoff RJ

    更新日期:1982-01-01 00:00:00

  • The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma.

    abstract::NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ma YY,Zhang GH,Li J,Wang SB,Hu ZM,Zhang CW,Li E

    更新日期:2018-12-01 00:00:00

  • Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.

    abstract::In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, lam...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Amenta PS,Briggs K,Xu K,Gamboa E,Jukkola AF,Li D,Myers JC

    更新日期:2000-03-01 00:00:00

  • Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma.

    abstract::Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity sq...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Choi SW,Kim JY,Park JY,Cha IH,Kim J,Lee S

    更新日期:2008-09-01 00:00:00

  • Cyclin D1 and MIB-1 immunohistochemistry in pilocytic astrocytomas: a study of 48 cases.

    abstract::Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Machen SK,Prayson RA

    更新日期:1998-12-01 00:00:00

  • Distribution of monoclonal antiferritin antibody in Kaposi's sarcoma, Hodgkin's disease, and hepatocellular carcinoma.

    abstract::The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJ

    更新日期:2003-04-01 00:00:00

  • Pure mucinous carcinomas of breast: morphologic features and prognostic correlates.

    abstract::Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Clayton F

    更新日期:1986-01-01 00:00:00

  • Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis.

    abstract::Lymphocytic colitis, previously termed "microscopic colitis", is a clinicopathologic syndrome of watery diarrhea, grossly normal colonoscopy, and mucosal inflammatory changes. Since lymphocytic colitis is a new, incompletely characterized entity, a histopathologic study was performed to compare lymphocytic colitis (n ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lazenby AJ,Yardley JH,Giardiello FM,Jessurun J,Bayless TM

    更新日期:1989-01-01 00:00:00

  • Male breast cancer: a case of apocrine carcinoma with psammoma bodies.

    abstract::A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Bryant J

    更新日期:1981-08-01 00:00:00

  • Expression of p16 in benign and malignant cystic squamous lesions of the neck.

    abstract::Metastatic cystic squamous cell carcinomas of the neck often harbor human papillomavirus 16 and, in turn, overexpress p16. P16 immunohistochemistry could be useful in the evaluation of patients who present with cystic squamous lesions of the neck, particularly when the distinction between a benign lymphoepithelial cys...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Cao D,Begum S,Ali SZ,Westra WH

    更新日期:2010-04-01 00:00:00

  • Human papillomavirus infection in esophageal carcinomas: a study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review.

    abstract::To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PC...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Poljak M,Cerar A,Seme K

    更新日期:1998-03-01 00:00:00

  • Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.

    abstract::High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Roger P,Montcourrier P,Maudelonde T,Brouillet JP,Pages A,Laffargue F,Rochefort H

    更新日期:1994-09-01 00:00:00

  • Atypia in breast fine-needle aspiration smears correlates poorly with the presence of a prognostically significant proliferative lesion of ductal epithelium.

    abstract::Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowd...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Stanley MW,Henry-Stanley MJ,Zera R

    更新日期:1993-06-01 00:00:00

  • Immunohistologic analysis of mycobacterial antigens by monoclonal antibodies in tuberculosis and mycobacteriosis.

    abstract::Four monoclonal antibodies (MoAbs), 60.15, 61.3, 105.10, and 2.16, directed to different proteins of Mycobacterium tuberculosis were used by an indirect avidin-biotin complex peroxidase-antiperoxidase method to detect mycobacterial antigens in lung, lymph node, and joint tissue specimens of tuberculous patients. Using...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Barbolini G,Bisetti A,Colizzi V,Damiani G,Migaldi M,Vismara D

    更新日期:1989-11-01 00:00:00

  • Histological features do not define NSAID-induced gastritis.

    abstract::Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 c...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: El-Zimaity HM,Genta RM,Graham DY

    更新日期:1996-12-01 00:00:00

  • Hemangiopericytoma of the esophagus.

    abstract::A case of hemangiopericytoma arising in the esophagus is described. The light microscopic features were typical, and ultrastructural examination confirmed the presence of pericyte-like cells and excluded smooth muscle and fibroblastic differentiation. Areas of necrosis and a focus of mitotic activity within the tumor ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Burke JS,Ranchod M

    更新日期:1981-01-01 00:00:00

  • Virtual microscopy: an evaluation of its validity and diagnostic performance in routine histologic diagnosis of skin tumors.

    abstract::Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nielsen PS,Lindebjerg J,Rasmussen J,Starklint H,Waldstrøm M,Nielsen B

    更新日期:2010-12-01 00:00:00

  • Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma.

    abstract::Recent studies demonstrated that protease-activated receptor-2 (PAR-2) correlates with tumor progression in various tissues. On the other hand, oxidative stress arising from endometriosis has been considered a cause of carcinogenesis in ovarian clear cell carcinoma (OCCC). We previously demonstrated that oxidative str...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Aman M,Ohishi Y,Imamura H,Shinozaki T,Yasutake N,Kato K,Oda Y

    更新日期:2017-06-01 00:00:00

  • Mineral oil (follicular) lipidosis: II. Histologic studies of spleen, liver, lymph nodes, and bone marrow.

    abstract::Tissues obtained from 600 routine autopsies were studied. Mineral oil lipidosis was present in the spleen (76 per cent), liver (45 per cent), bone marrow (26 per cent), and lymph nodes; more than 50 per cent of the lymph nodes from the mesentery, porta hepatis, and mediastinum were affected. Mineral oil and its metabo...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Cruickshank B,Thomas MJ

    更新日期:1984-08-01 00:00:00

  • The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma.

    abstract::Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of p...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Karnik T,Ozawa MG,Lefterova M,Luna-Fineman S,Alvarez E,Link M,Zehnder JL,Arber DA,Ohgami RS

    更新日期:2015-04-01 00:00:00

  • Immunohistochemical analysis of retroperitoneal Müllerian cyst.

    abstract::Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Konishi E,Nakashima Y,Iwasaki T

    更新日期:2003-02-01 00:00:00

  • Semiquantitative assessment of cytomorphologic features can predict mutation status of thyroid nodules with indeterminate cytologic diagnosis.

    abstract::Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Shahi M,Bloechl SJ,Vogel RI,Shrestha R,Krigman HR,Evasovich M,Burmeister LA,Amin K

    更新日期:2019-11-01 00:00:00

  • Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate.

    abstract::This study investigate the expression of the mitogen-activated protein kinases (MAPKs) in normal prostate, benign prostatic hyperplasia (BPH), and prostatic cancer (PC), and also the possible relationship between the activity of these MAPKs and the apoptosis/proliferation index. Immunochemical techniques were carried ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Royuela M,Arenas MI,Bethencourt FR,Sánchez-Chapado M,Fraile B,Paniagua R

    更新日期:2002-03-01 00:00:00

  • Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease.

    abstract::In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Stamm BH

    更新日期:1984-07-01 00:00:00

  • Pathogenesis of "fibrosis" in interstitial pneumonia: an electron microscopic study.

    abstract::Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Katzenstein AL

    更新日期:1985-10-01 00:00:00

  • Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system.

    abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究


    authors: Massone C,Soyer HP,Lozzi GP,Di Stefani A,Leinweber B,Gabler G,Asgari M,Boldrini R,Bugatti L,Canzonieri V,Ferrara G,Kodama K,Mehregan D,Rongioletti F,Janjua SA,Mashayekhi V,Vassilaki I,Zelger B,Zgavec B,Cerroni L,K

    更新日期:2007-04-01 00:00:00

  • Evaluation of 2 whole-slide imaging applications in dermatopathology.

    abstract::Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Velez N,Jukic D,Ho J

    更新日期:2008-09-01 00:00:00

  • Acquired coronary arterial aneurysms: an autopsy study of 52 patients.

    abstract::In the past decade most studies of coronary arterial aneurysms have been clinical; few have focused on morphology and etiopathogenesis. The subjects of the present autopsy study were 52 patients, 5 months to 80 years of age, with coronary arterial aneurysms. Patients were divided into two groups: 38 with atherosclerot...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Virmani R,Robinowitz M,Atkinson JB,Forman MB,Silver MD,McAllister HA

    更新日期:1986-06-01 00:00:00

  • Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma.

    abstract::Our aim was to investigate the expression of micro-RNA-200b (miR-200b) and cAMP-responsive element-binding protein 1 (CREB-1) in astrocytoma and its efficacy for predicting outcome. Both miR-200b and CREB-1 messenger RNA expression was measured in 122 astrocytomas and 30 nonneoplastic brain specimens by quantitative r...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Zhang JQ,Yao QH,Kuang YQ,Ma Y,Yang LB,Huang HD,Cheng JM,Yang T,Liu EY,Liang L,Fan KX,Zhao K,Xia X,Gu JW

    更新日期:2014-10-01 00:00:00