Abstract：
:Overexpression of mitotic arrest deficient 2 (MAD2) and/or cell division cycle 20 (CDC20) in the spindle assembly checkpoint leads to chromosomal instability and aneuploidy. Cell-in-cell (CIC) structures are formed by the process where cancer or immune cells are internalized into adjacent host cancer cells. Here, we investigated the clinicopathological significances of spindle assembly checkpoint protein overexpression and CIC structures in 829 cases of normal, premalignant, and gastric cancer (GC) lesions. MAD2 and CDC20 expressions were significantly increased in intestinal metaplasia, low-grade dysplasia, high-grade dysplasia (HGD), and early GC than normal mucosa, and their expression levels were the highest in HGD. Interestingly, CDC20 immunohistochemistry specifically stained the outer cells of CIC structures, which were the most frequently observed in early GC. In univariate analyses, MAD2 and CDC20 overexpressions and CIC formation were associated with older age, intestinal histology, lower tumor-node-metastasis stage, and longer recurrence-free survival and cancer-specific survival of GC patients. In multivariate survival analyses, MAD2 and CDC20 overexpressions were associated with better recurrence-free survival (hazard ratio, 0.61; P = .012) and cancer-specific survival (hazard ratio, 0.63; P = .043), respectively. In conclusion, MAD2 and CDC20 are the most expressed in HGD, suggesting their roles in the early stage of gastric carcinogenesis, whereas their overexpressions in GC are associated with intestinal histology and favorable clinicopathological parameters, which may be useful for immunohistochemical classification of chromosomal instability-type GC. Moreover, CDC20 is a novel immunohistochemical marker for highlighting CIC structures.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kim Y,Choi JW,Lee JH,Kim YSdoi
10.1016/j.humpath.2018.10.029subject
Has Abstractpub_date
2019-03-01 00:00:00pages
174-183eissn
0046-8177issn
1532-8392pii
S0046-8177(18)30428-3journal_volume
85pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Hepatic artery thrombosis (HAT) following orthotopic liver transplantation (OLT) can cause hepatic parenchymal necrosis and ischemic cholangiopathy. This study investigates additional histologic features that may suggest HAT in post-OLT liver specimens. For 94 liver specimens (explanted allografts and biopsies) from p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.04.019
更新日期：2019-08-01 00:00:00
abstract：:The case of an infant with endocardial fibroelastosis and a coexistent anomalous right coronary artery that originated from the pulmonary trunk is presented. The causal relation between the two conditions is discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80138-6
更新日期：1985-09-01 00:00:00
abstract：:We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90210-4
更新日期：1989-01-01 00:00:00
abstract：:Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.11.008
更新日期：2018-02-01 00:00:00
abstract：:The histologic findings in lymph nodes were used to identify eight patients, who are not in a high-risk group, with human immunodeficiency virus (HIV) infection. In order to determine the specificity of these findings, the histologic and clinical findings in these patients were compared with the histologic and clinica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80269-7
更新日期：1988-07-01 00:00:00
abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.013
更新日期：2006-05-01 00:00:00
abstract：:We studied the histopathologic, immunohistochemical, and ultrastructural features of the extracellular matrix (ECM) in 20 immunologically defined large-cell lymphomas, including immunoblastic sarcoma of B cells (three patients), peripheral T cell lymphoma (five patients), large non-cleaved follicular center cell (FCC)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90181-0
更新日期：1989-02-01 00:00:00
abstract：:Esophageal and colorectal adenocarcinomas overexpress Fas ligand (FasL), which can protect them from immune surveillance. The aim of this work was to determine whether FasL expression, and therefore FasL-dependent immune evasion, occurs early during malignant transformation in Barrett's metaplasia (BM) of the esophagu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90061-8
更新日期：1999-11-01 00:00:00
abstract：:Four cases of clear cell lymphoma were studied by means of light and electron microscopy, enzyme-histochemistry, and E- and EAC-rosette formation. On light microscopic examination the tumors were seen to be composed mainly of round, oval, or slight irregular cells with water-clear, abundant cytoplasm. The neoplastic c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80258-2
更新日期：1988-07-01 00:00:00
abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90185-4
更新日期：1997-06-01 00:00:00
abstract：:Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.11.011
更新日期：2006-03-01 00:00:00
abstract：:Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.31476
更新日期：2002-02-01 00:00:00
abstract：:We introduce a novel hybrid telepathology system providing simultaneous transmission of both real-time microscopy and static imagery at a reasonable cost. It is capable of capturing static, true color images at resolution of 1,520 x 1,144 pixels and providing live transmission of real-time video images of the glass sl...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.9196
更新日期：2000-07-01 00:00:00
abstract：:Demonstration of identical allelic loss on chromosome 11q13 in synchronous in situ (DCIS) and invasive ductal (IDC) breast carcinoma has provided molecular evidence of the progression of DCIS to IDC. We investigated loss of heterozygosity (LOH) at chromosome 11q13 in the spectrum of "marker/premalignant" and "malignan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90124-6
更新日期：1997-03-01 00:00:00
abstract：:Immunohistochemical localization of transforming growth factor beta 1 (TGF-beta 1) was studied in Kaposi's sarcoma (KS) tissues obtained from autopsy and biopsy materials of patients with and without acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) infection. There was no difference in t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90241-4
更新日期：1995-05-01 00:00:00
abstract：:Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80375-1
更新日期：1987-11-01 00:00:00
abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90110-o
更新日期：1992-03-01 00:00:00
abstract：:Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80028-8
更新日期：1978-07-01 00:00:00
abstract：:We describe a method for the immunocytochemical assessment of estrogen receptor (ER) status on routinely processed, formalin-fixed tissue using a recently developed commercially available monoclonal antibody (Dako 1D5) with a microwave antigen retrieval technique. A series of 90 cases of human breast carcinoma was ana...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90060-8
更新日期：1995-03-01 00:00:00
abstract：:Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained for GATA binding protein 3...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2012.02.011
更新日期：2012-11-01 00:00:00
abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.6276
更新日期：2000-09-01 00:00:00
abstract：:Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Und...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(83)80006-9
更新日期：1983-06-01 00:00:00
abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:We studied the histopathology and clinicopathologic correlates of invasive cavitary pulmonary aspergillosis in 11 immunosuppressed patients with disseminated malignancy. In most patients cavities were produced by separation of necrotic from viable lung, resulting in an intracavitary sequestrum ("lung ball"). Central d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90202-x
更新日期：1994-03-01 00:00:00
abstract：:Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonsemin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.09.007
更新日期：2019-02-01 00:00:00
abstract：:In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.011
更新日期：2011-10-01 00:00:00
abstract：:Dermatofibrosarcoma protuberans is genetically characterized by the translocation t(17;22)(q22;q13) resulting in the PDGFB/COL1A1 fusion gene. Fluorescence in situ hybridization with specific probes enables a rapid detection of this gene. In this study, the presence of the translocation t(17;22)(q22;q13) by fluorescen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.07.015
更新日期：2011-02-01 00:00:00
abstract：:Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2003.12
更新日期：2003-02-01 00:00:00
abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2011.07.020
更新日期：2012-04-01 00:00:00
abstract：:In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80294-4
更新日期：1984-07-01 00:00:00
