Abstract:
:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the development of squamous intraepithelial lesions and to determine the best diagnostic indicator(s) linked to the appearance of an HSIL. Ninety-nine cervical biopsies, 18 normal, 9 with metaplastic changes, 29 LSIL, and 43 HSIL (23 cervical intraepithelial neoplasia 2 and 20 cervical intraepithelial neoplasia 3), were analyzed by image cytometry for DNA ploidy and p16INK4A determination, AgNOR counting, MIB-1, and ICBP90 immunostaining quantification. The human papillomavirus status had been previously determined on corresponding cytological smears with the Hybrid Capture II test. Suspect DNA profile and p16INK4A staining were the first significant events that preceded the increase of cell proliferation. Indeed, these markers were the best tests for the detection of a lesion, whatever its grade (positive predictive values of 90% and 100%, respectively). The presence of MIB-1- or ICBP90-positive cells in the upper two thirds of the epithelium was a very accurate feature to select HSIL (sensitivity, 100% for MIB-1) but with a low specificity. The sensitivity of a suspect DNA profile associated with a positive MIB-1 or ICPB90 immunostaining for the detection of an HSIL was, respectively, 92.8% and 92.7%; their specificities were 54.2% and 44%; their positive predictive values were 78% and 73%; their negative predictive values were 81.2% and 78.6%; and the global values were 78.8% and 74.3%. Thus, the most accurate test to distinguish an LSIL from an HSIL was the association of a suspect DNA profile and the presence of MIB-1- or ICBP90-positive cells in the upper two thirds of the epithelium.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Lorenzato M,Caudroy S,Bronner C,Evrard G,Simon M,Durlach A,Birembaut P,Clavel Cdoi
10.1016/j.humpath.2005.07.016subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1101-7issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(05)00398-9journal_volume
36pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::The objective of this study was to compare the expression of the nerve growth factor (NGF) receptors TrkA and p75 in ovarian borderline tumors, International Federation of Gynecology and Obstetrics (FIGO) stage I carcinomas and advanced-stage (FIGO stage III-IV) carcinomas, and to assess a possible association between...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.027
更新日期:2007-01-01 00:00:00
abstract::Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.7894
更新日期:2000-06-01 00:00:00
abstract::To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80005-6
更新日期:1976-01-01 00:00:00
abstract::The clinical spectrum of coronavirus disease 2019 is getting wider with the exponential increase of patients worldwide. Initially described with flu-like symptoms, variable cutaneous manifestations have been reported, with only few histopathological descriptions. Detection of the virus in cutaneous samples has been as...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.10.011
更新日期:2021-01-01 00:00:00
abstract::Pseudomonas pneumonia is an uncommon but serious infection in infants, occurring mainly in infants of low birth weight. In this retrospective clinicopathologic correlation study, we reviewed the clinical records and analyzed postmortem lung pathology in 8 infants with pneumonia due to P. aeruginosa. From the histopath...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(03)00353-8
更新日期:2003-09-01 00:00:00
abstract::Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.04.011
更新日期:2007-08-01 00:00:00
abstract::Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.12.012
更新日期:2017-04-01 00:00:00
abstract::We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.018
更新日期:2018-03-01 00:00:00
abstract::Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80031-8
更新日期:1983-03-01 00:00:00
abstract::The histopathology of 72 paragangliomas originating in the head and neck region of 71 patients is presented. There were 45 carotid body, 13 vagal body, eight jugulotympanic, and three nasal paragangliomas. In addition, two arose in the larynx and one in the area of the aortic arch. Tumors occurred in four unrelated fa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(79)80008-8
更新日期:1979-03-01 00:00:00
abstract::Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.016
更新日期:2012-09-01 00:00:00
abstract::T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.030
更新日期:2017-07-01 00:00:00
abstract::To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90088-x
更新日期:1993-04-01 00:00:00
abstract::The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80409-4
更新日期:1987-12-01 00:00:00
abstract::Giant cell pneumonia associated with parainfluenza virus type 3 infection and chronic poliovirus type 2 meningoencephalomyelitis are documented in an infant with combined immunologic deficiency (Swiss type). Caution should be exercised in attributing cases of giant cell pneumonia to measles virus without serologic or ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80032-9
更新日期:1981-05-01 00:00:00
abstract::We have begun a systematic study of human papillomavirus (HPV) infection in colposcopically and/or morphologically normal epithelium of the uterine cervix. Paired biopsies were taken from the lesions (cervical intraepithelial neoplasia [CIN], condyloma, invasive carcinoma) and from the normal-appearing adjacent epithe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90039-7
更新日期:1989-04-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.04.014
更新日期:2013-10-01 00:00:00
abstract::In the past few years many clinically significant new glomerular lesions have been reported from observations made on renal biopsy specimens by electron microscopy. The clinical applicability of electron microscopy is illustrated by examples of specific ultrastructural patterns of glomerular reaction making possible a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(75)80060-8
更新日期:1975-07-01 00:00:00
abstract::Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90041-m
更新日期:1991-02-01 00:00:00
abstract::Congenital cystic airway malformation/congenital pulmonary airway malformation (CCAM/CPAM) of the lung is a rare but well-described malformative lesion of pulmonary parenchyma characterized by the abnormal maturation of airways along with an increase in terminal respiratory structures, resulting in cysts of variable s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.04.009
更新日期:2007-12-01 00:00:00
abstract::As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.02.003
更新日期:2018-05-01 00:00:00
abstract::Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90023-5
更新日期:1998-12-01 00:00:00
abstract::Prior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investigate the relationsh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.05.009
更新日期:2012-03-01 00:00:00
abstract::This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.012
更新日期:2017-01-01 00:00:00
abstract::Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated pro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.01.010
更新日期:2017-07-01 00:00:00
abstract::Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.012
更新日期:2011-10-01 00:00:00
abstract::Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90401-n
更新日期:1992-08-01 00:00:00
abstract::Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90277-0
更新日期:1999-02-01 00:00:00
abstract::The Mix1 homeobox-like (MIXL1) gene encodes a paired class homeobox transcription factor that is involved in embryogenesis. Previous studies have shown that the MIXL1 gene product is expressed in B- and T-cell progenitors of normal bone marrow and, in some cell lines derived from hematopoietic neoplasms. The status of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.020
更新日期:2007-03-01 00:00:00
abstract::An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.12.020
更新日期:2012-10-01 00:00:00