Abstract：
:Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on the possible role of activating transcription factor 3 in skin cancer. In this study, we investigated the expression of activating transcription factor 3 in basal cell carcinomas (n = 5), actinic keratoses (n = 7), squamous cell carcinomas (n = 19), and Bowen disease (n = 14) by immunohistochemistry. In results, activating transcription factor 3 was significantly expressed in squamous cell carcinomas (15/19), suggesting that it is involved in the pathogenesis of squamous cell carcinomas but not in basal cell carcinomas (0/5). In addition, higher expression of activating transcription factor 3 was observed in squamous cell carcinomas that were metastatic (P < .01) or arose in organ transplant recipients (P < .05). Therefore, activating transcription factor 3 appears to play an oncogenic role in the development of squamous cell carcinomas and may be related to the biologic behavior of them.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kim MS,In SG,Park OJ,Won CH,Lee MW,Choi JH,Kim CW,Kim SE,Moon KC,Chang Sdoi
10.1016/j.humpath.2010.10.008subject
Has Abstractpub_date
2011-07-01 00:00:00pages
954-9issue
7eissn
0046-8177issn
1532-8392pii
S0046-8177(10)00388-6journal_volume
42pub_type
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