Abstract:
:Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased serum levels of creatine kinase (CK), MB fraction of CK (CK-MB), and cTnT, although she did not complain of cardiac symptoms. Electrocardiographic monitoring, echocardiography, magnetic resonance computed angiography, and percutaneous coronary angiography excluded myocardial damage. However, the close follow-up showed a steady increase of CK-MB and cTnT levels and gradual development of weakness in both thighs. A biopsy of the right quadriceps muscle led to the diagnosis of inclusion body myositis. In contrast to cTnT, cardiac troponin I could not be detected retrospectively in any of her serum samples. These results demonstrate for the first time that cTnT is elevated in patients with inclusion body myositis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Schwarzmeier JD,Hamwi A,Preisel M,Resl C,Preusser M,Sluga E,Horcher E,Shehata MMdoi
10.1016/j.humpath.2005.06.009subject
Has Abstractpub_date
2005-08-01 00:00:00pages
917-21issue
8eissn
0046-8177issn
1532-8392pii
S0046-8177(05)00286-8journal_volume
36pub_type
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