Abstract：
:Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the present study, HSP10 expression in 242 cases of IDBC and 46 cases of noncancerous breast tissues was detected by immunohistochemistry staining. High expression was significantly more common in IDBC than in noncancerous breast tissues (P<.001). Also, high expression was significantly more common in poorly differentiated than in well- and moderately differentiated IDBC (P=.023). Furthermore, high expression correlated negatively with estrogen receptor and progesterone receptor expression (P=.031 and P=.042, respectively). The most interesting result of the study was that high expression of HSP10 was significantly associated with shorter overall survival by both univariate and multivariate analyses (P=.013 and P=.036, respectively). In conclusion, we report for the first time that high expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in IDBC.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Chu S,Wen Q,Qing Z,Luo J,Wang W,Chen L,Feng J,Xu L,Zang H,Fan Sdoi
10.1016/j.humpath.2016.09.039subject
Has Abstractpub_date
2017-03-01 00:00:00pages
173-180eissn
0046-8177issn
1532-8392pii
S0046-8177(16)30349-5journal_volume
61pub_type
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